The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

“…In our study, the prevalence of metabolic syndrome in patients with NAFLD was 26.4%, which is higher than that in the US general population (23.7%) [21] but is surprisingly lower than that reported in Iranian general population which was reported to be as high as 30%-31% [22,23] . On the other hand, the prevalence of metabolic syndrome in our NAFLD population is also relatively lower than that in other NAFLD series (32.3%) [24] . With no doubt, these discrepancies come from the selection criteria employed in this study which excluded diabetic patients, and shows that how much our data can be affected by including diabetic patients into NAFLD analysis.…”

“…Several metabolic factors have been associated to increased ALT activity in patients with NAFLD, including BMI, insulin resistance, and metabolic syndrome components, e.g., central obesity, raised triglycerides, reduced HDL-C, and raised fasting glucose [24] . In the current study, we found that patients with pathologically increased levels of ALT represented no higher serum levels of triglyceride, HDL-C levels, BMI, and prevalence of central obesity than those in patients with normal serum ALT levels.…”

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

“…Increased ALT concentrations are considered to be a risk factor strongly associated with coronary artery disease and metabolic disease [9,10]. However, it is uncertain whether ALT concentration within the reference range assures freedom from NAFLD or cardiometabolic diseases.…”

Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

“…Of these liver enzymes, ALT is most closely related to liver fat accumulation, and is often used in epidemiological studies as a surrogate marker for NAFLD (Schindhelm et al, 2006). Elevated plasma ALT levels are associated with obesity and the MS Oh et al, 2006), whose central features are abdominal obesity, dyslipidemia, hypertension and hyperglycemia. In addition, some prospective epidemiological studies have demonstrated that high activity of ALT, independent of age, obesity and Journal of Zhejiang University SCIENCE B ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.zju.edu.cn/jzus; www.springerlink.com E-mail: jzus@zju.edu.cn alcohol intake, is associated with the occurrence of type 2 diabetes mellitus and the MS (Hanley et al, 2005;Schindhelm et al, 2007;Doi et al, 2007;.…”