The association between insulin resistance, metabolic variables, and depressive symptoms in Mexican‐American elderly: A population‐based study

Diniz, Breno S.; Fisher‐Hoch, Susan P.; McCormick, Joseph B.

doi:10.1002/gps.4792

Cited by 22 publications

(16 citation statements)

References 34 publications

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“…Overall, these findings are in line with previous studies from Hispanic and non-Hispanic populations where both depression and diabetes are associated with increased inflammatory and metabolic markers (Diniz et al, 2010(Diniz et al, , 2016Smagula et al, 2016). They also expand recent findings suggesting that insulin resistance is associated with higher depressive symptoms in a predominantly first generation of Mexican American older adults, that higher inflammatory status can significantly increase mortality risk in older adults with depression and diabetes, and that abnormalities in the insulin signaling cascade are related to cognitive impairment in older adults with late-life depression (Castro-Costa et al, 2019;Diniz et al, 2011Diniz et al, , 2018.…”

supporting

confidence: 76%

Biomarkers intersection between depression, diabetes, and cognitive impairment

Diniz

2020

Int. Psychogeriatr.

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supporting

confidence: 76%

Biomarkers intersection between depression, diabetes, and cognitive impairment

Diniz

2020

Int. Psychogeriatr.

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“… 97 , 98 , 99 , 100 Ethnicity has to be included among the risk factors and Hispanics and particularly Mexican and Mexican-American individuals carry higher risk of cardiometabolic diseases and AD. 101 , 102 , 103 Slow gait and risk of cognitive impairment are also described in APOE4 carriers 94 , a finding relevant to our MMC populations carrying an allele 4 in∼20% and accelerating AD neuropathology staging in the first 2 decades of life. 32 …”

Section: Discussionmentioning

confidence: 78%

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Calderón‐Garcidueñas

Torres-Solorio

Kulesza

et al. 2020

Environmental Research

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To determine whether gait and balance dysfunction are present in young urbanites exposed to fine particular matter PM 2.5 ≥ annual USEPA standard, we tested gait and balance with Tinetti and Berg tests in 575 clinically healthy subjects, age 21.0±5.7y who were residents in Metropolitan Mexico City, Villahermosa and Reynosa. The Montreal Cognitive Assessment was also applied to an independent cohort n:76, age 23.3± 9.1y. In the 575 cohort, 75.4% and 34.4% had abnormal total Tinetti and Berg scores and high risk of falls in 17.2% and 5.7% respectively. BMI impacted negatively Tinetti and Berg performance. Gait dysfunction worsen with age and males performed worse than females. Gait and balance dysfunction were associated with mild cognitive impairment MCI (19.73%) and dementia (55.26%) in 57/76 and 19 cognitively intact subjects had gait and balance dysfunction. Seventy-five percent of urbanites exposed to PM 2.5 had gait and balance dysfunction. For MMC residents-with historical documented Alzheimer disease (AD) and CSF abnormalities, these findings suggest Alzheimer Continuum is in progress. Early development of a Motoric Cognitive Risk Syndrome ought to be considered in city dwellers with normal cognition and gait dysfunction. The AD research frame in PM 2.5 exposed young urbanites should include gait and balance measurements. Multicity teens and young adult cohorts are warranted for quantitative gait and balance measurements and neuropsychological and brain imaging studies in high vs low PM 2.5 exposures. Early identification of gait and balance impairment in young air pollution-exposed urbanites would facilitate multidisciplinary prevention efforts for modifying the course of AD.

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Section: Riskmentioning

confidence: 99%

“…There is a large body of literature suggesting a bidirectional association between depression and diabetes, and the comorbidity between these 2 conditions is high (Diniz, Fisher‐Hoch, & McCormick, , Holt et al, , Katon et al, , Korczak, Pereira, Koulajian, Matejcek, & Giacca, , Moulton et al, , Vancampfort et al, ). The comorbidity between depression and diabetes leads to significant adverse outcomes such as less adequate glycemic control (Lustman, Anderson, Freedland, de Groot, & Carney, ; GDB Risk Factor Collaboration, 2016); more diabetic complications (GDB Risk Factor Collaboration, 2016); increased service use, and lower medication adherence (Ciechanowski, Katon, Russo, & Hirsch, ; Egede, Bishu, Walker, & Dismuke, ; Gonzalez et al, ).…”

Section: Introductionmentioning

confidence: 99%

Diabetes, depressive symptoms, and mortality risk in old age: The role of inflammation

et al. 2019

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Background Both diabetes and depression increase the mortality risk in the elderly. In this study, we evaluated mortality risk associated with the comorbidity between depression and diabetes. We also assessed the moderating role of inflammation in the mortality risk in this population. Methods We included a total of 1,183 community‐dwelling older adults, divided into four groups: “neither diabetes nor depression”; “diabetes only”; “depression only,” and “both diabetes and depression,” and followed‐up for a median of 13.5 years. We evaluated the inflammatory status by the high‐sensitivity C‐reactive protein (hs‐CRP) levels. Date of death was computed by reviewing death certificates. We used Cox's proportional hazards models and additive interactions to evaluate the risk of mortality in the subject groups and the moderating effect of hs‐CRP. Results Participants with both diabetes and depression had higher death risk (hazard ratio [HR]: 2.33; 95% confidence interval [CI]: 1.59–3.42) than those with each condition alone (HR diabetes: 2.08 95% CI: 1.56–2.76 HR depression: 1.26; 95% CI: 1.03–1.54). High level of hs‐CRP, indicative of high inflammatory status, significantly moderated the risk of mortality in subjects with both diabetes and depression (Bonferroni‐adjusted p = 0.0116). Conclusions The coexistence of diabetes and depression symptoms is associated with the highest death risk in this population. This risk is moderated by inflammatory status.

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The association between insulin resistance, metabolic variables, and depressive symptoms in Mexican‐American elderly: A population‐based study

Cited by 22 publications

References 34 publications

Biomarkers intersection between depression, diabetes, and cognitive impairment

Biomarkers intersection between depression, diabetes, and cognitive impairment

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Diabetes, depressive symptoms, and mortality risk in old age: The role of inflammation

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