The association between leukocyte telomere lengths and sleep instability based on cardiopulmonary coupling analysis

Kwon, Amy M.; Baik, Inkyung; Thomas, Robert J.; Shin, Chol

doi:10.1007/s11325-014-1110-x

Cited by 13 publications

(13 citation statements)

References 28 publications

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“…Details of the cohort design and recruitment have been reported elsewhere. [17,18] In the present study, we analyzed polysomnography (PSG) and spirometry measurements of a total of 1298 study participants evaluated during 2013 to 2014, in addition to their regular cohort examinations on demographic characteristics (age, sex, smoking and drinking status, height, weight, and circumference of neck), sleep-related factors (sleep quality, insomnia, and snoring), and health-related factors (BMI, blood pressure, use of medication for hypertension, diabetes mellitus, and presence of diabetes, cardiovascular diseases, cancers, and asthma). The institutional review board of Korea University Ansan Hospital approved the study protocol (approval number: AS0624).…”

Section: Methodsmentioning

confidence: 99%

Overlap syndrome of COPD and OSA in Koreans

et al. 2017

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Overlap syndrome of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) leads to increased morbidity and mortality. There have been no reports available on the overlap syndrome for Koreans. Our primary aim was to identify prevalence and predictors of the overlap syndrome in Koreans.This is a cross-sectional study with a community-based sample of 1298 participants (mean age, 59.7 ± 6.7) from the cohort of Korean Genomic and Epidemiologic Study during 2013 to 2014. OSA and COPD were assessed by apnea–hypopnea index (AHI) and the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC < 70%), respectively, based on polysomnography and spirometry measurements. Using logistic regression with adjustment for the confounders identified by univariate analysis, odds ratio (OR) was estimated with 95% confidence interval (CI) of COPD among those with OSA.The prevalence rate of OSA was 45.8%, of which 32.8% were moderate-to-severe (AHI ≥ 15); 10.8% of those having OSA also had COPD, that is, the overlap syndrome. The prevalence of COPD remained the same as 10.8% regardless of the presence of OSA. The mean ratio of FEV1/FVC for those with COPD was 0.77, regardless of OSA. The OR increased for age (OR, 1.1; 95% CI, 1.0–1.1) and smokers (OR, 3.6; 95% CI, 2.0–6.4), but decreased for body mass index (BMI) (OR, 0.84; 95% CI, 0.8–0.9) and overweight state (OR, 0.4; 95% CI, 0.2–0.7). Risk factors of the overlap syndrome differed by OSA severity, that is, BMI in those with moderate-to-severe OSA, whereas sex (OR, 4.7; 95% CI, 2.1–10.6) and age (OR, 1.1; 95% CI, 1.0–1.1) in those with mild OSA.In a population study from Korea, 10.8% of OSA patients had an overlap syndrome with COPD. Although BMI is a well-known risk factor of OSA, it is likely that being overweight may be protective for moderate-to-severe OSA patients from the risk of COPD (i.e., overlap syndrome).

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Section: Methodsmentioning

confidence: 99%

Overlap syndrome of COPD and OSA in Koreans

et al. 2017

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“…As a community-based cohort study, the Korean Genome and Epidemiology Study (KoGES) consortium demonstrated a significant association between leukocyte telomere length (LTL) and elevated narrow-band low frequency coupling (e-LFC NB ) via interacting with OSAHS severity (P <0.0001) [34]. Carroll et al [35] assessed whether sleep apnea is related to LTL in the Multi-Ethnic Study of Atherosclerosis (MESA), and found that severe OSAHS (AHI > 30) was crosssectionally associated with shorter LTL (P = 0.007) when adjusting for ethnicity/race, age, sex, body mass index (BMI), smoking, and physical activity, while these effects were diminished after treating OSAHS.…”

Section: Osahs and Telomere Attritionmentioning

confidence: 99%

“…Tempaku et al [30] demonstrated that hypoxia is the most important OSAHS-related factor associated with shortened TL, and found that OSAHS may result in attrition of TL and promote acceleration of aging. IH due to OSAHS is likely a major contributor to shortened TL in middle-aged men [34][35][36][37]. Kim et al [32] pointed out that the serum concentration of hydrogen peroxide was markedly higher in OSAHS patients, which was closely associated with the severity of OSAHS.…”

Section: Osahs and Telomere Attritionmentioning

confidence: 99%

Obstructive Sleep Apnea-hypopnea Syndrome as a Novel Potential Risk for Aging

Li¹,

Wang²

2021

Aging and disease

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Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder, negatively influencing individuals' quality of life and socioeconomic burden. In recent years, OSAHS has been reported in not only constituting an aging-associated disease, but also in accelerating and/or potentiating aging mechanisms. However, the negative impacts of OSAHS on aging are underestimated because of low level of public awareness about this disease and high rates of undiagnosed cases, which are more critical in developing countries or economically disadvantaged regions. Hence, reviewing previously reported observations may assist scholars to better indicate that OSAHS is likely a novel potential risk for aging. Further understanding of the pathophysiological mechanism of OSAHS and its role in procession of aging may markedly highlight the importance of this common sleep disorder.

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“…21,22 Leukocyte TL Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine TL. 23 Genomic DNA was extracted from peripheral blood leukocytes using QIAamp DNA mini kit (QIAGEN, Germany). The ratio of the telomere repeat copy number to the single-copy gene (36B4 gene which encodes acidic ribosomal phosphoprotein) copy number, was determined for relative leukocyte telomere length (TL) by using the iQ Multi-Color Real-Time PCR Detection System (Bio-Rad, CA, USA).…”

Section: Polysomnographymentioning

confidence: 99%