The Association Between Major Birth Defects and Preterm Birth

Honein, Margaret A.; Kirby, Russell S.; Meyer, Robert E.; Xing, Jian; Skerrette, Nyasha I.; Yuskiv, Nataliya; Marengo, Lisa; Petrini, Joann; Davidoff, Michael J.; Cara, T.; Druschel, Charlotte M.; Viner-Brown, Samara; Sever, Lowell E.

doi:10.1007/s10995-008-0348-y

Cited by 114 publications

(98 citation statements)

References 44 publications

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“…CP diagnoses can be regarded as reliable, because they are made in public hospitals in specialized units of child neurology. The prevalence of congenital anomalies has been 2.2 times greater in infants born at 32 to 36 weeks of gestation compared with term infants, 32 which is a significant confounder when seeking perinatal risk factors. Here, as elsewhere, 33 all infants with major congenital anomalies were excluded.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Palsy Among Children Born Moderately and Late Preterm

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: The incidence of cerebral palsy is dependent on the gestational age in very preterm infants and risk factors have been identified for term infants. The risk has also proved to be greater among late preterm births compared with term. WHAT THIS STUDY ADDS:The incidence of cerebral palsy was 24-fold in moderately preterm and 6-fold in late preterm infants compared with full-term infants. The most prominent risk factors included asphyxia and intracranial hemorrhage. The incidence diminished over time and with increasing gestational age. (,32 +0 weeks) and term infants ($37 weeks). METHODS:The national register study included all live-born infants in Finland from 1991 to 2008. Infants who died before the age of 1 year, had any major congenital anomaly, or had missing data were excluded. A total of 1 018 302 infants were included in the analysis and they were analyzed in 4 subgroups (VP, MP, LP, and term) and 3 time periods (1991-1995, 1996-2001, and 2002-2008).RESULTS: By the age of 7 years, 2242 children with CP were diagnosed (0.2%). CP incidence was 8.7% in the VP, 2.4% in the MP, 0.6% in the LP, and 0.1% in the term group. Dr Hirvonen drafted the initial manuscript and participated in the analytic planning; Drs Ojala, Korhonen, Haataja, Eriksson, and Gissler participated in the analytic planning and critically reviewed and revised the manuscript; Ms Luukkaala conducted the statistical analyses and critically reviewed and revised the manuscript; Dr Tammela designed and supervised the study and critically reviewed and revised the manuscript; and all authors approved the final manuscript as submitted.www.pediatrics.org/cgi

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Section: Discussionmentioning

confidence: 99%

Cerebral Palsy Among Children Born Moderately and Late Preterm

et al. 2014

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“…Higher rates of congenital malformations have been found in preterm infants than in term infants (Honein et al, 2009;Kugelman & Colin, 2013). It is well known that craniofacial abnormalities place infants at risk for feeding difficulties (Miller, 2009;Rogers & Arvedson, 2005).…”

Section: The Importance Of a Quiet Environment Successful Oral Feedimentioning

confidence: 99%

Breastfeeding Characteristics of Late-Preterm Infants in a Kangaroo Mother Care Unit

Pike

Kritzinger

Krüger

2017

Breastfeeding Medicine

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Title:Breastfeeding characteristics of latepreterm infants in a kangaroo mother care unit. AbstractObjective: To describe the breastfeeding characteristics of late-preterm infants (LPIs) in a kangaroo mother care unit (KMC). Materials and methods:In a 20-bed KMC unit, the breastfeeding of 73 purposively-selected LPIs' (mean gestational age: 34.8 weeks) was observed once-off, using the Preterm Infant Breastfeeding Behavior Scale. Participants' mean age was 9.5 days, mean number of days in the unit was 3.1 days, and mean number of days breastfeeding was 7.5 days on observation.

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“…[2006][2007]. Median age at death was day 3 after birth for infants with a BD who died (25th-75th percentiles: days [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Coded cause of death was congenital malformation for 95% of infants with BDs who died within 12 hours after birth, whereas immaturity was the coded cause for 75% of infants without BDs who died early.…”

Section: Types Of Birth Defectsmentioning

confidence: 99%

“…1 Population-based epidemiologic data demonstrate an association between preterm birth or low birth weight and various BDs. [2][3][4][5][6][7][8] The extent to which BDs may impact neonatal morbidity and mortality associated with preterm delivery remains unclear. Improved understanding of the frequency of BDs and outcomes in premature or low birth weight infants may help guide medical decision-making and counseling to families of affected newborns.…”

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confidence: 99%

Ten-Year Review of Major Birth Defects in VLBW Infants

et al. 2013

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OBJECTIVE: Birth defects (BDs) are an important cause of infant mortality and disproportionately occur among low birth weight infants. We determined the prevalence of BDs in a cohort of very low birth weight (VLBW) infants cared for at the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) centers over a 10-year period and examined the relationship between anomalies, neonatal outcomes, and surgical care. METHODS: Infant and maternal data were collected prospectively for infants weighing 401 to 1500 g at NRN sites between January 1, 1998, and December 31, 2007. Poisson regression models were used to compare risk of outcomes for infants with versus without BDs while adjusting for gestational age and other characteristics. RESULTS: A BD was present in 1776 (4.8%) of the 37 262 infants in our VLBW cohort. Yearly prevalence of BDs increased from 4.0% of infants born in 1998 to 5.6% in 2007, P < .001. Mean gestational age overall was 28 weeks, and mean birth weight was 1007 g. Infants with BDs were more mature but more likely to be small for gestational age compared with infants without BDs. Chromosomal and cardiovascular anomalies were most frequent with each occurring in 20% of affected infants. Mortality was higher among infants with BDs (49% vs 18%; adjusted relative risk: 3.66 [95% confidence interval: 3.41–3.92]; P < .001) and varied by diagnosis. Among those surviving >3 days, more infants with BDs underwent major surgery (48% vs 13%, P < .001). CONCLUSIONS: Prevalence of BDs increased during the 10 years studied. BDs remain an important cause of neonatal morbidity and mortality among VLBW infants.

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The Association Between Major Birth Defects and Preterm Birth

Cited by 114 publications

References 44 publications

Cerebral Palsy Among Children Born Moderately and Late Preterm

Cerebral Palsy Among Children Born Moderately and Late Preterm

Breastfeeding Characteristics of Late-Preterm Infants in a Kangaroo Mother Care Unit

Ten-Year Review of Major Birth Defects in VLBW Infants

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