The association between maternal and paternal race and preterm birth

Green, Celeste A.; Johnson, Jeff; Vladutiu, Catherine J.; Manuck, Tracy A.

doi:10.1016/j.ajogmf.2021.100353

Cited by 9 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fourthly, Matsushita et al pointed out that maternal pre-pregnancy obesity was significantly associated with the risk of preterm birth, but the risk varies according to maternal age, race or ethnic group (14). A similar statement may also exist in the association between paternal pre-pregnancy BMI and offspring's birth health (44). Fifthly, the fetuses in this study all had live births.…”

Section: Discussionsupporting

confidence: 58%

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

Sun

Zhang²,

Chen³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundWith the current global epidemic of obesity, especially among men, there is a need to understand its impact on adverse pregnancy outcomes. This study aimed to assess whether paternal pre-pregnancy body mass index (BMI) was associated with preterm birth and low birth weight in offspring.MethodsMultinomial logistic regression model was used to analyze associations between paternal BMI and preterm birth and low birth weight in different subgroups, the final model was adjusted for confounding factors of mothers and fathers. Further subgroup analysis was conducted to explore the stability of the risk associations.ResultsA total of 34,104 participants were included in this study, including 1,442 (4.2%) underweight, 13,930 (40.9%) overweight and 5,008 (14.7%) obese according to paternal BMI. The total incidence of preterm birth was 11.85% (4041/34104), and the incidence of low birth weight was 8.86% (3020/34104). In the total study population, compared with normal weight men, paternal pre-pregnancy overweight or obese was associated with a significantly increased risk of preterm birth [aOR; 95% CI respectively (1.34; 1.25–1.45 vs. 1.26; 1.14–1.40)] and low birth weight [aOR; 95% CI respectively (1.60; 1.46–1.74 vs. 1.40; 1.25–1.58)] in offspring. The results of subgroup analysis showed that the direction of the risk association was consistent, indicating good stability.ConclusionPaternal pre-pregnancy overweight and obesity were associated with an increased risk of preterm birth and low birth weight in their offspring.

show abstract

Section: Discussionsupporting

confidence: 58%

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

Sun

Zhang²,

Chen³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…However, Salihu et al used birthweight ≥4000 g to define fetal macrosomia without stratification by gestational age; the unified definition may fail to capture transgenerational momentum in the absence of race-sensitive and gestational age-adjusted definitions, given the high prevalence of preterm births [45] . Underestimation may occur more significantly in populations of color, among which both obesity and preterm birth are inappropriately higher [24,46] . The current analysis confirmed the temporality of the causal relationship between macrosomia and obesity using race- and sex-specific percentiles rather than one cutoff value of birth weight for all newborns.…”

Section: Discussionmentioning

confidence: 99%

Macrosomia is associated with overweight in childhood: a follow-back of a cohort established in the early years of the obesity epidemic

Adebile

Orji

Twum

et al. 2023

Reproductive and Developmental Medicine

View full text Add to dashboard Cite

Objective: Interventions currently recommended to control and prevent obesity have not been successful. Recent research has shifted toward the transgenerational cycle of obesity. We assessed the association between fetal macrosomia and early childhood body weight.Methods: We conducted a follow-back study to link birth certificate data to the Third National Health and Nutrition Examination Survey (1988-1994) of 2621 United States-born singletons aged 2-6 years. Birth weight and gestational age data were collected from birth certificates. Fetal macrosomia was defined as ≥90th percentile of gestational age-race-sex-parity specific body weight distribution in 1989 vital statistics.Results: With 12.7% (standard error = 0.85%) of participants born macrosomic, the prevalence of obesity and overweight (BMI percentiles ≥85th in the CDC growth chart) among children was 17.8% (1.17%). When the body weight was measured against age-sex-specific height (BMI percentiles), macrosomia was significantly associated with overweight and obesity (odds ratio [OR] = 1.64, 95% confidence interval = 1.07-2.50) adjusted for family income, maternal age and marital status, race, maternal smoking during pregnancy, and breastfeeding. The association became insignificant after adjusting for postnatal lifestyle and parental body mass index ]. When body weight was measured against age, children who were too heavy for their age were more likely to be born macrosomically ) than their peers with healthy age-specific body weight. Conclusion:Fetal macrosomia was significantly associated with a doubled risk of heavy body weight in children aged 2-6 years.

show abstract

“…Of particular interest is the role of the fetus and its possible thrombophilia even if the exact fetal contribution to placental disfunction is not yet well delineated. The hypothesis of a paternal role in the link between thrombophilia and obstetrical diseases stems from observations that the fetus may have an inherited thrombophilic state, such as the factor V Leiden mutation, not present in the mother [ 25 , 26 ]. The hypothesis contemplated concerns the delicate balance between pro- and anticoagulant factors at the feto-placental interface, therefore the phenomena of fibrin deposition and infarction could arise either from the maternal or fetal side, or from both.…”

Section: The Father and The Thrombophilic Fetusmentioning

confidence: 99%

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

Giannubilo,

Marzioni,

Tossetta

et al. 2024

Biology

View full text Add to dashboard Cite

Pregnancy is generally studied as a biological interaction between a mother and a fetus; however, the father, with his characteristics, lifestyle, genetics, and living environment, is by no means unrelated to the outcome of pregnancy. The half of the fetal genetic heritage of paternal derivation can be decisive in cases of inherited chromosomal disorders, and can be the result of de novo genetic alterations. In addition to the strictly pathological aspects, paternal genetics may transmit thrombophilic traits that affect the implantation and vascular construction of the feto-placental unit, lead to placenta-mediated diseases such as pre-eclampsia and fetal growth retardation, and contribute to the multifactorial genesis of preterm delivery. Biological aspects of immunological tolerance to paternal antigens also appear to be crucial for these pathologies. Finally, this review describes the biological findings by which the environment, exposure to pathogens, lifestyle, and nutritional style of the father affect fetal pathophysiological and epigenetic definition.

show abstract

The association between maternal and paternal race and preterm birth

Cited by 9 publications

References 17 publications

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

Association between paternal pre-pregnancy body mass index with preterm birth and low birth weight

Macrosomia is associated with overweight in childhood: a follow-back of a cohort established in the early years of the obesity epidemic

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

Contact Info

Product

Resources

About