The association between maternal fat-soluble vitamin concentrations during pregnancy and infant birth weight in China

Yang, Wangxing; Jiao, Mingyuan; Xi, Lei; Han, Na; Luo, Shusheng; Xu, Xiangrong; Zhou, Qianling; Wang, Haijun

doi:10.1017/s0007114520003347

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…Diet was assessed using a 24 h recall and a 3-day food record [71]. This is in accordance with a recent large prospective study showing that maternal serum vitamin A concentrations during pregnancy were positively associated with LBW, and negatively associated with macrosomia [72]. Conversely, a recent systematic review and meta-analysis of 17 trials reported that vitamin A or beta-carotene levels during pregnancy did not have a significant overall effect on birthweight indicators, preterm birth, stillbirth, miscarriage or fetal loss [73].…”

Section: Discussionsupporting

confidence: 72%

Maternal Diet Influences Fetal Growth but Not Fetal Kidney Volume in an Australian Indigenous Pregnancy Cohort

et al. 2021

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Suboptimal nutrition during pregnancy is recognised as a significant modifiable determinant in the development of chronic disease in offspring in later life. The current study aimed: (i) to assess the dietary intakes of pregnant Indigenous Australian women against national recommendations and (ii) to investigate the associations between maternal nutrition during pregnancy and the growth of the offspring, including kidney development in late gestation in the Gomeroi gaaynggal cohort (n = 103). Maternal dietary intake in the third trimester was assessed using the Australian Eating Survey Food Frequency Questionnaire. Estimated fetal weight (EFW) and kidney size were obtained by ultrasound. Birth weight was retrieved from hospital birth records. Of the five key nutrients for optimal reproductive health (folate, iron, calcium, zinc and fibre), the nutrients with the highest percentage of pregnant women achieving the nutrient reference values (NRVs) were zinc (75.7%) and folate (57.3%), whereas iron was the lowest. Only four people achieved all NRVs (folate, iron, calcium, zinc and fibre) important in pregnancy. Sodium and saturated fat intake exceeded recommended levels and diet quality was low, with a median score of 28 out of 73 points. After adjusting for smoking and pre-pregnancy body mass index, only maternal intake of retinol equivalents and the proportion of energy from nutrient-dense or energy-dense, nutrient-poor (EDNP) foods were associated with fetal growth. EFW decreased by 0.13 g and birth weight decreased by 0.24 g for every µg increase in maternal dietary retinol intake. Interestingly, EFW, but not actual birth weight, was positively associated with percentage energy from nutrient dense foods and negatively associated with percentage energy from EDNP foods. Dietary supplement usage was associated with increased birthweight, most significantly iron and folate supplementation. Current dietary intakes of pregnant Australian women from this cohort do not align with national guidelines. Furthermore, current findings show that maternal retinol intake and diet composition during pregnancy can influence fetal growth, but not fetal kidney growth in late gestation. Strategies that aim to support and optimise nutrient intakes of Indigenous pregnant women are urgently needed. Future studies with long-term follow-up of the children in the current cohort to assess renal damage and blood pressure are imperative.

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Section: Discussionsupporting

confidence: 72%

Maternal Diet Influences Fetal Growth but Not Fetal Kidney Volume in an Australian Indigenous Pregnancy Cohort

et al. 2021

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“…The meta-analysis was a secondary analysis primarily based on RCTs. Neonatal outcomes involved in exploring the effects of maternal vitamin D deficiency on offspring, including small-for-gestational-age ( 40 ), neonatal bone mass ( 41 ), infant glucose metabolism ( 42 ), infant atopic dermatitis ( 43 ), infant acute respiratory infections ( 37 ), infant birth weight ( 44 ), offspring sex ratio ( 45 ), infant gut microbiota ( 46 ), offspring socioemotional development ( 47 ), infant neurodevelopment ( 48 , 49 ).…”

Section: Resultsmentioning

confidence: 99%

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

Zhang

et al. 2022

Front. Nutr.

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BackgroundVitamin D plays an invaluable role in reproductive health, but vitamin D insufficiency and deficiency are generally common among couples of childbearing age and pregnant women. This study aimed to evaluate the evolution, development trend, and research hotspot of publications on vitamin D and reproductive health.MethodsThe literature on vitamin D and reproductive health between 2012 and 2021 was retrieved from the Web of Science Core Collection (WoSCC). We used VOSviewer and CiteSpace to analyze publication years, countries, institutions, journals, highly cited authors and publications, and co-occurrence and citation bursts of keywords.ResultsA total of 1,828 articles and reviews on vitamin D and reproductive health published between 2012 and 2021 were identified. The annual publication outputs showed steady growth, with the most publications (272) and citations (7,097) in 2021. The United States contributed the most publications (458) and had the highest h-index (58). In terms of the number of publications and h-index, the journal named Nutrients ranked first. Nutrition dietetics, obstetrics gynecology, and endocrinology metabolism were three well-represented disciplines in research on vitamin D and reproductive health. Hollis BW, Wagner CL, and Litonjua AA were the top three most productive authors in this field during the last decade. Apart from vitamin D, the five keywords with the most frequent occurrence were vitamin D deficiency, pregnancy, risk, vitamin D supplementation, and 25-hydroxyvitamin D. Keyword citation burst analysis revealed that low birth weight, adipose tissue, marker, and embryo had a citation burst lasting until 2021.ConclusionIn conclusion, vitamin D has received continuous attention in the field of reproductive health, and there appears to have a higher level of research in North America. Multidisciplinary intersection contributed to the in-depth exploration in this field. And the effect of maternal vitamin D levels on fetal lipid metabolism and the prediction of fertility by vitamin D-related markers might be hotspots for the research.

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“…Of the limited number of studies that have assessed the relationship of VDD and neonatal growth to date, findings have been mixed [ 22 , 24 , 67 ] and significant associations have been shown to vary by pregnancy trimester. For example, in a study of pregnant women in Spain ( n = 2358), maternal vitamin D was measured at 13–15 weeks gestation.…”

Section: Discussionmentioning

confidence: 99%

“…Deficiency (defined as 25(OH)D < 20 ng/ml or < 69 nmol/L) was evident in 19.6% of women and was shown to predict fetal overweight (fetal weight ≥ 90 th percentile) and abdominal adiposity (abdominal circumference ≥ 90 th percentile) at birth [ 31 ]. In a separate study of Chinese women who had vitamin D assessed during the second ( n = 11,634) and third trimester of pregnancy ( n = 6609), median 25(OH)D concentration was found to be ~ 66 nmol/L, an maternal vitamin D in the third but not second trimester was negatively associated with macrosomia but not with birthweight, after adjustment for multiple confounders [ 67 ]. Variation in assessment timepoints of vitamin D during pregnancy, difference in the techniques used to analyse 25(OH)D, variation in cut points used to define VDD or variation in adjustment for critical confounders such as season of sample collection likely explain the observed inconsistent results across studies.…”

Section: Discussionmentioning

confidence: 99%

Maternal plasma vitamin D levels across pregnancy are not associated with neonatal birthweight: findings from an Australian cohort study of low-risk pregnant women

Pligt

Ellery

Guingand

et al. 2023

BMC Pregnancy Childbirth

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Background In utero environments can be highly influential in contributing to the development of offspring obesity. Specifically, vitamin D deficiency during pregnancy is associated with adverse maternal and child health outcomes, however its relationship with offspring obesity remains unclear. We assessed maternal vitamin D status across pregnancy, change in plasma vitamin D concentrations and associations with neonatal birthweight, macrosomia and large for gestational age. Methods Women (n = 221) aged 18–40 years with singleton (low-risk) pregnancies, attending antenatal clinics at a tertiary-level maternity hospital were recruited at 10–20 weeks gestation. Medical history, maternal weight and blood samples at three antenatal clinic visits were assessed; early (15 ± 3 weeks), mid (27 ± 2 weeks) and late (36 ± 1 weeks) gestation. Maternal 25(OH)D was analysed from stored plasma samples via liquid chromatography-tandem mass spectrometry (LC/MS/MS). Neonatal growth parameters were collected at birth. Unadjusted and adjusted linear and logistic regression assessed associations of maternal vitamin D with birthweight, macrosomia and large for gestational age. Results Mean plasma 25(OH)D increased from early (83.8 ± 22.6 nmol/L) to mid (96.5 ± 28.9 nmol/L) and late (100.8 ± 30.8 nmol/L) gestation. Overall 98% of women were taking vitamin D-containing supplements throughout their pregnancy. Prevalence of vitamin D deficiency (25(OH)D < 50 nmol/L) was 6.5%, 6.3% and 6.8% at early, mid and late pregnancy respectively. No statistically significant association was found between 25(OH)D or vitamin D deficiency at any timepoint with neonatal birthweight, macrosomia or large for gestational age. Conclusions Prevalence of vitamin D deficiency was low in this cohort of pregnant women and likely related to the high proportion of women taking vitamin D supplements during pregnancy. Maternal 25(OH)D did not impact offspring birth weight or birth size. Future studies in high-risk pregnant populations are needed to further assess maternal vitamin D status and factors in utero which promote early life obesity.

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The association between maternal fat-soluble vitamin concentrations during pregnancy and infant birth weight in China

Cited by 12 publications

References 30 publications

Maternal Diet Influences Fetal Growth but Not Fetal Kidney Volume in an Australian Indigenous Pregnancy Cohort

Maternal Diet Influences Fetal Growth but Not Fetal Kidney Volume in an Australian Indigenous Pregnancy Cohort

A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: Learning from the past, planning for the future

Maternal plasma vitamin D levels across pregnancy are not associated with neonatal birthweight: findings from an Australian cohort study of low-risk pregnant women

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