The association between maternal parity and birth defects

McNeese, Melanie L.; Selwyn, Beatrice J.; Duong, Hao T.; Canfield, Mark A.; Waller, D. Kim

doi:10.1002/bdra.23360

Cited by 17 publications

(13 citation statements)

References 57 publications

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“…Additional research into the potential biological mechanisms of this reduced risk association warrant further investigation. We also found there to be an inverse association with increasing parity which adds evidence to another previous observation of a higher odds of gastroschisis for first births (McNeese, Selwyn, Duong, Canfield, & Waller, ).…”

Section: Discussionsupporting

confidence: 88%

A machine learning approach to investigate potential risk factors for gastroschisis in California

Weber

Yang

Carmichael

et al. 2018

Birth Defects Research

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Background To generate new leads about risk factors for gastroschisis, a birth defect that has been increasing in prevalence over time, we performed an untargeted data mining statistical approach. Methods Using data exclusively from the California Center of the National Birth Defects Prevention Study, we compared 286 cases of gastroschisis and 1,263 non‐malformed, live‐born controls. All infants had delivery dates between October 1997 and December 2011 and were stratified by maternal age at birth (<20 and ≥ 20 years). Cases and controls were compared by maternal responses to 183 questions (219 variables) using random forest, a data mining procedure. Variables deemed important by random forest were included in logistic regression models to estimate odds ratios and 95% confidence intervals. Results Among women younger than 20, of variables deemed important, there were higher odds observed for higher consumption of chocolate, low intake of iron, acetaminophen use, and urinary tract infections during the beginning of pregnancy. After adjustment, the higher odds remained for low iron intake and a urinary tract infection in the first month of pregnancy. Among women aged 20 or older, of variables deemed important, higher odds were observed for US‐born women of Hispanic ethnicity and for parental substance abuse. There were lower odds observed for obese women, women who ate any cereal the month before pregnancy, and those with higher parity. Conclusions We did not discover many previously unreported associations, despite our novel approach to generate new hypotheses. However, our results do add evidence to some previously proposed risk factors.

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Section: Discussionsupporting

confidence: 88%

A machine learning approach to investigate potential risk factors for gastroschisis in California

Weber

Yang

Carmichael

et al. 2018

Birth Defects Research

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“…Women having their first birth had significantly increased odds of having an infant with 24 of 65 categories of birth defects when compared to women having their second birth. 19 This finding is similar with study done by Fatema et al in Bangladesh.…”

Section: Maternal Factorssupporting

confidence: 91%

Birth Defect and it’s Impact in Neonatal Health : A Review

Mannan

Afroze

Dey

et al. 2019

Bangladesh J Child Health

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Birth defects are one of the leading causes of neonatal mortality worldwide. Every year more than 8.14 million children are born with a serious birth defect. The risk factors predictive of birth defects in babies vary from country to country even from region to region. About 60% of the causes of birth defect in humans are still unknown. However, in about 25% cases, the causes seem to be “multifactorial”, indicating a complex interaction between genetic and environmental risk factors. Many studies have been conducted to determine the association of various risk factors with the incidence of birth defects. Most of them found significant association with maternal age, parity, consanguinity, poor nutrition, life style factors, low socioeconomic condition and many more. But still there is debate in certain issues like common type of birth defect, specific age of mother for having birth defect babies, role of drugs during pregnancy etc. With advancement of diagnostic tools, birth defects can be identified both prenatally and post- natally. This helps further in decision making and planning for both parents as well as physicians to provide accurate treatment in time. Major birth defect babies require intensive care and more hospitalization. Often multidisciplinary approach is essential for them. But till now birth defect cases are neglected in society. Increasing awareness about maternal care during pregnancy, educational programs on birth defect and the consequences of consanguineous marriages need to be highlighted to decrease the incidence of birth defect and their co-morbidities as well as mortality. Bangladesh J Child Health 2019; VOL 43 (1) :49-58

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“…and 7 malformations in 24 with live birth and pregnancy loss Group (7.14%). These observations of associations with first births were consistent with observations by McNeese ML et al and Csermely G et al 8,9 Further research on specific parameters viz biological, behavioral, and environmental factors and their association with first births need further exploration. In the present study in midtrimester abortions, the most common system with congenital malformations was CNS (23.46%) followed by multiple defects (9.18%) followed by the musculoskeletal system (5.10%) and other systems as mentioned above.…”

Section: -5supporting

confidence: 89%