The Association between Matrix Metalloproteinase-3 -1171 (5A/6A) Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

Abstract

Review question / Objective: The polymorphism of the 5A/6A promoter region of matrix metalloproteinases-3-1171 has been comprehensively studied to evaluate its risk associated with various cancers. We performed this updated meta-analysis to clarify the inconclusive outcomes of previous studies and to verify the link of this specific variant with the cancer risk. Eligibility criteria: For the literature covered in this meta-analysis, the authors followed some standards as inclusion criteria: (a) comparative case-control or cohort (different case groups) studies stating the correlation of MMP-3 -1171 (5A/6A) variant with cancer risk; (b) Available genotype and allele data in cases and controls; (c) Sufficient data to determine ORs (odds ratios) with 95% Cis (confidence intervals). The substandard studies were: (a) Review articles, commentaries and duplicate studies; (b) Study graph apart from case-control comparative approaches; (c) Studies having inadequate genotypic information to compute ORs with 95% CIs.