The Association Between Matrix Metalloproteinase-7 A-181G Polymorphism and the Risk of Relapsing-Remitting Multiple Sclerosis in Iranian Kurdish Patients from Kermanshah

Abstract

Background: Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system. The relapsing-remitting-MS (RR-MS) is the most common form of this disease. Matrix metalloproteinase-7 (MMP-7) is an important member of the MMP family, which degrades many extracellular matrix components. The common polymorphism of MMP-7 A-181G is associated with some diseases. Objectives: The aim of the present study was to determine the influence of this polymorphism on the risk of RR-MS. Materials and Methods: Eighty RR-MS patients and 80 healthy individuals as controls from the Kermanshah province were studied for MMP-7 A-181G polymorphism by using the PCR-RFLP method. Data were analyzed using the SPSS statistical software package version 16.0. Results: In RR-MS patients the frequency of MMP-7 GG genotype was significantly (P = 0.028) higher compared to that of the controls. The presence of GG genotype increased the risk of RR-MS by 1.69 times [OR = 1.69 and 95% CI = 1.05-2.72, P = 0.03]. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P = 0.043) than that of the controls (40%). The presence of this allele increased the risk of RR-MS by 1.58 folds (P = 0.044). Conclusions: Our findings indicate that the presence of G allele of MMP-7 A-181G polymorphism might increase the risk of RR-MS in our population.

Role of MMP-7 in the pathogenesis of systemic lupus erythematosus (SLE)

“…in 2015, in which the frequency of the MMP-7 GG genotype was reported to be significantly higher in relapsing-remitting (RR) MS patients compared to that of healthy controls and concluded that the presence of this allele increases the risk of RRMS 1.58-fold. 13 A similar observation was reported in our study showing an association between the MMP-7 G allele and a 4.17-fold increase in risk for SLE. We did not find a significant association between the A/G + G/G genotype and autoantibody production except dsDNA autoantibodies ( p = 0.0312).…”

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

“…Furthermore, MMP7 degrades soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and increases the bioavailability of VEGF 165 , which promotes angiogenesis [42]. The G allele of the MMP7 -181 A/G SNP creates a putative binding site for a heat shock transcription factor, thereby increasing MMP7 gene promoter activity and transcription compared to the -181 A allele [34]. The G allele has been reported as a potential risk factor for several gynecological disorders, including endometriosis and adenomyosis [32], as well as endometrial [27], ovarian [26], and cervical cancers [28].…”

“…In the present study, we extended this analysis to MMP7 and 12 genes, both of which exert important functions in pregnancy, including implantation and remodeling of spiral arteries. Additionally, polymorphisms in these genes have been investigated in different disorders, including gynecological [26][27][28] and non-gynecological cancers [29][30][31], as well as reproductive disorders [32,33] and various systemic disorders [34][35][36]. Our aim was to evaluate the potential association between IRSA in Slovenian reproductive couples and MMP7 -181 A/G and MMP12 -82 A/G functional SNPs, which are located in gene promoter regions.…”