The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance

Kikuchi, Naoki; Fuku, Noriyuki; Matsumoto, Ryûtarô; Matsumoto, Shingo; Murakami, Haruka; Miyachi, Motohiko; Nakazato, Koichi

doi:10.1055/s-0042-117113

Cited by 26 publications

(48 citation statements)

References 21 publications

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“…Fedotovskaya et al [ 19 ] suggested that the frequency of the A allele and AA genotype was significantly higher in endurance-oriented athletes. We have reported that the AA genotype is associated with athletic status of Japanese wrestlers [ 20 ]. In addition, our previous study suggested that athletes with the AA genotype had lower blood lactate concentrations than those with the T allele during/after the Cycling Repeat Sprint Test and 10 min after the Wingate Test [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…We have reported that the AA genotype is associated with athletic status of Japanese wrestlers [ 20 ]. In addition, our previous study suggested that athletes with the AA genotype had lower blood lactate concentrations than those with the T allele during/after the Cycling Repeat Sprint Test and 10 min after the Wingate Test [ 20 ]. Cupeiro et al [ 21 ] demonstrated the same trend for high intensity circuit training.…”

Section: Introductionmentioning

confidence: 99%

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Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers

Ginszt¹,

Massidda²,

Okamoto³

et al. 2021

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Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene is associated with athletic performance and physiological phenotypes. The purpose of this study was to investigate the frequency of MCT1 T1470A polymorphism in Polish and Japanese climbers using a case-control study. Our sample consisted of 226 climbers (Japanese: n = 100, 64 male and 36 female; Polish: n = 126, 97 male and 29 female) and 1028 non-athletic controls (Japanese, n = 407; Polish = 621) who were genotyped for the MCT1 T1470A polymorphism (rs1049434) using the TaqMan SNP genotyping assay or restriction enzyme. The frequency of the TT genotype and T allele was significantly higher in climbers than in controls among the Polish subjects (genotype: p = 0.030, allele: p = 0.010); however, there were no significant differences in the genotype and allelic frequencies between the Japanese climbers and controls (genotype: p = 0.968; allele: p = 0.803). Our results suggested that the frequency of the T allele (TT+TA genotype) in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. In addition, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers

Ginszt¹,

Massidda²,

Okamoto³

et al. 2021

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“…The heritability of reaction time has been shown to reach 60% [ 14 ]. At least 5 genetic markers (located within ACE , ACTN3 , FTO , HIF1A and MCT1 genes; involved in metabolism, skeletal muscle structure and function) have previously been shown to be linked to wrestler status [ 5 , 15 – 18 ]. However, genetic association analysis in wrestlers using DNA polymorphisms previously associated with reaction time has not been performed.…”

Section: Introductionmentioning

confidence: 99%

Whole genome sequencing of elite athletes

Boulygina¹,

Borisov²,

Valeeva³

et al. 2020

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Whole genome sequencing (WGS) has great potential to explore all possible DNA variants associated with physical performance, psychological traits and health conditions of athletes. Here we present, for the first time, annotation of genomic variants of elite athletes, based on the WGS of 20 Tatar male wrestlers. The maximum number of high-quality variants per sample was over 3.8 M for single nucleotide polymorphisms (SNPs) and about 0.64 M for indels. The maximum number of nonsense mutations was 148 single nucleotide variants (SNVs) per individual. Athletes’ genomes on average contained 18.9 nonsense SNPs in a homozygous state per sample, while non-athletes’ exomes (Tatar controls, n = 19) contained 18 nonsense SNPs. Finally, we applied genomic data for the association analysis and used reaction time (RT) as an example. Out of 1884 known genome-wide significant SNPs related to RT, we identified four SNPs ( KIF27 rs10125715, APC rs518013, TMEM229A rs7783359, LRRN3 rs80054135) associated with RT in wrestlers. The cumulative number of favourable alleles ( KIF27 A, APC A, TMEM229A T, LRRN3 T) was significantly correlated with RT both in wrestlers ( P = 0.0003) and an independent cohort ( n = 43) of physically active subjects ( P = 0.029). Furthermore, we found that the frequencies of the APC A (53.3 vs 44.0%, P = 0.033) and LRRN3 T (7.5 vs 2.8%, P = 0.009) alleles were significantly higher in elite athletes (n = 107) involved in sports with RT as an essential component of performance (combat sports, table tennis and volleyball) compared to less successful (n = 176) athletes. The LRRN3 T allele was also over-represented in elite athletes (7.5%) in comparison with 189 controls (2.9%, P = 0.009). In conclusion, we present the first WGS study of athletes showing that WGS can be applied in sport and exercise science.

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“…In humans, SLC16A1 has been established as one of the most important genes related to exercise predisposition. Mutations within the SLC16A1 locus are included in genetic marker tests used for the prediction of sprint or athletic performance in athletes [8–11].…”

Section: Introductionmentioning

confidence: 99%

The use of the SLC16A1 gene as a potential marker to predict race performance in Arabian horses

Ropka‐Molik

Stefaniuk‐Szmukier²,

Szmatoła³

et al. 2019

BMC Genet

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Background Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the rates of lactate production and utilization are critical to avoid muscle fatigue and a decrease in exercise performance. The key factor determining transmembrane lactate transport is the monocarboxylate transporter 1 protein coded for by the SLC16A1 gene. The aim of the present research was to identify polymorphisms in the coding sequence and UTRs in the equine SLC16A1 gene and to evaluate their potential association with race performance traits in Arabian horses. Based on RNA-seq data, SNPs were identified and genotyped using PCR-RFLP or PCR-HRM methods in 254 Arabian horses that competed in flat races. An association analysis between polymorphisms and racing results was performed. Results Novel polymorphisms in the equine SLC16A1 locus have been identified (missense and 5’UTR variants: g.55601543C > T and g.55589063 T > G). Analysis showed a significant association between the 5’UTR polymorphism and several racing results as follows: the possibility of winning first or second place, the number of races in which horses started and total financial benefits. The analysis also showed differences in genotype distribution depending on race distance. In the studied population, the shorter distance races were only won by TT horses. The GG and TG horses took first and second places in middle- and long-distance races, and the percentage of winning heterozygotes increased from 19.5 to 27% at the middle and long distances, respectively. The p.Val432Ile (g.55601543C > T) polymorphism was not significantly related to the analysed racing results. Conclusion Our results showed that g.55589063 T > G polymorphism affected the possibility of winning first or second place and of competing in more races. The different distribution of genotypes depending on race distance indicated the possibility of using a SNP in the SLC16A1 gene as a marker to predict the best race distance for a horse. The presented results provide a basis for further research to validate the use of the SLC16A1 gene as a potential marker associated with racing performance.

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The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance

Cited by 26 publications

References 21 publications

Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers

Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers

Whole genome sequencing of elite athletes

The use of the SLC16A1 gene as a potential marker to predict race performance in Arabian horses

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