The Association between Medication Adherence and Lung Function among Patients with Cystic Fibrosis.

Eakin, MN; Bilderback, AS; Boyle, MP; Mogayzel, PJ; Riekert, KA

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1088

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“…Furthermore, we hypothesized that patients with the highest adherence would have sustained improvement in lung function. Some of the results of these studies have been reported previously as abstracts [13,14]. …”

Section: Introductionmentioning

confidence: 99%

Longitudinal association between medication adherence and lung health in people with cystic fibrosis

Eakin

Bilderback

Boyle

et al. 2011

Journal of Cystic Fibrosis

199

226

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Background This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1% predicted (FEV1). Methods 95 CF patients ages 6 years or older and prescribed a pulmonary medication, enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=.007), but not decline in FEV1. Conclusions These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

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Section: Introductionmentioning

confidence: 99%