The association between metabolic abnormality and endometrial cancer: A large case-control study in China

Zhang, Yan; Liu, Zhiwei; Yu, Xinghua; Zhang, Xiaofei; Lü, Shiming; Chen, Xiaoduan; Lü, Bingjian

doi:10.1016/j.ygyno.2009.12.029

Cited by 100 publications

(86 citation statements)

References 37 publications

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“…Zhang et al reported positive correlations of EC risk with TC, TG and LDL-C, but a negative correlation with HDL-C, which matched with our study. 25 By studying all cases of endometrioid endometrial cancer we found that some patients were metformin users and some non-users irrespective to the other criteria of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

The impact of metabolic syndrome on the clinical profile and tumor characteristics of endometrial carcinoma

Tawfik

ElSabaa

Elneily

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

The impact of metabolic syndrome on the clinical profile and tumor characteristics of endometrial carcinoma

Tawfik

ElSabaa

Elneily

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…7,8 Endometrial cancer is a hormone-dependent cancer, and obesity affects hormone metabolism by increasing aromatization of androstenedione to estrone in adipose tissues. 8,9 In addition, obesity increases circulating levels of estrogen, which creates a conducive environment for tumor formation. 4,9 Other risk factors for endometrial cancer include physical inactivity, unopposed estrogen therapy, chronic hyperinsulinemia, tamoxifen, and early menarche, late onset of menopause, polycystic ovarian syndrome, and diabetes.…”

mentioning

confidence: 99%

The Impact of Obesity on Surgical Outcome in Endometrial Cancer Patients: A Systematic Review

Orekoya

Samson

Trivedi

et al. 2016

Journal of Gynecologic Surgery

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Background: Obesity is a significant public health problem in the United States, and many studies have established obesity as a significant risk factor for endometrial cancer. Surgery is the standard of care in staging and treatment of endometrial cancer, and obesity may influence surgical outcomes because of its attendant comorbid conditions. Therefore, assessment of the impact of obesity on surgical outcome is important for decreasing morbidity and improving survival in patients with endometrial cancer. Objective: The aims of this research were to evaluate and review epidemiologic data systematically on the impact of obesity on surgical outcomes and to assess safety and feasibility of newer surgical techniques in obese patients. Materials and Methods: A systematic search of PubMed was conducted to identify articles between 2004 and 2013 that focused on the impact of obesity on surgical outcome. Reference lists of retrieved articles were also used to identify other relevant articles. Thirteen relevant articles were reviewed. Results: Evidence from epidemiologic studies showed that obesity impacts surgical outcome adversely. On average, obese patients have worse surgical outcomes than their nonobese counterparts. In addition, surgical outcome worsens as level of obesity increases. However, surgical procedure also influences this association. Minimally invasive surgeries are more useful and are accompanied with fewer complications than conventional laparotomy and can be performed safely in obese patients. Conclusions: Obesity is a significant risk in the etiology, treatment, and surgical outcomes of patients with endometrial cancer. Future research will need more randomized controlled trials and prospective studies to identify the best procedures for maximal outcomes. ( J GYNECOL SURG 32:149)

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“…A pooled analysis of six of these studies reported a non-statistically significant increased risk of 35-39 % with higher cholesterol intake (29) . Studies of serum cholesterol have shown similar mixed results (35)(36)(37)(38)(39)(40)(41) . Our results are consistent with the increased EC risk observed for dietary cholesterol from pooled estimates.…”

Section: Discussionmentioning

confidence: 91%

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

Biel

Csizmadi

Cook

et al. 2011

Public Health Nutr.

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Objective: Intake of nutrients may influence the risk of endometrial cancer (EC). We aimed to estimate the association of intake of individual nutrients from food and from food plus supplements with EC occurrence. Design: A population-based case-control study conducted in Canada (2002Canada ( -2006. Setting: Nutrient intakes from food and supplements were assessed using an FFQ. Logistic regression was used to estimate EC risk within quartile levels of nutrient intakes. Subjects: Incident EC cases (n 506) were identified from the Alberta Cancer Registry, and population controls were frequency-and age-matched to cases (n 981). Results: There existed little evidence of an association with EC for the majority of macronutrients and micronutrients examined. We observed a statistically significant increased risk associated with the highest, compared with the lowest, quartile of intake of dietary cholesterol (multivariable-adjusted OR 5 1?51, 95 % CI 1?08, 2?11; P for trend 5 0?02). Age-adjusted risk at the highest level of intake was significantly reduced for Ca from food sources (OR 5 0?73, 95 % CI 0?54, 0?99) but was attenuated in the multivariable model (OR 5 0?82, 95 % CI 0?59, 1?13). When intake from supplements was included in Ca intake, risk was significantly reduced by 28 % with higher Ca (multivariable-adjusted OR 5 0?72, 95 % CI 0?51, 0?99, P for trend 5 0?04). We also observed unexpected increased risks at limited levels of intakes of dietary soluble fibre, vitamin C, thiamin, vitamin B 6 and lutein/zeaxanthin, with no evidence for linear trend. Conclusions: The results of our study suggest a positive association between dietary cholesterol and EC risk and an inverse association with Ca intake from food sources and from food plus supplements.

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The association between metabolic abnormality and endometrial cancer: A large case-control study in China

Cited by 100 publications

References 37 publications

The impact of metabolic syndrome on the clinical profile and tumor characteristics of endometrial carcinoma

The impact of metabolic syndrome on the clinical profile and tumor characteristics of endometrial carcinoma

The Impact of Obesity on Surgical Outcome in Endometrial Cancer Patients: A Systematic Review

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

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