The association between metabolic syndrome and successful aging- using an extended definition of successful aging

Lin, Yi‐Hsuan; Chiou, Jeng‐Min; Chen, Ta‐Fu; Lai, Liang‐Chuan; Chen, Jen‐Hau; Chen, Yen‐Ching

doi:10.1371/journal.pone.0260550

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…Among the perspectives for future studies focused on the prevention of MS during aging, we must consider the influence of eating habits, such as the consumption of fruits and vegetables and high-calorie intake during dinner [ 45 , 46 ], the gut microbiota profile [ 47 ], the characteristics of social support networks [ 48 ], socioeconomic inequalities, age and gender [ 49 ], as well as the relationship and prognosis of the components of the metabolic syndrome with successful aging [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Community Gerontology Program on the Control of Metabolic Syndrome in Mexican Older Adults

et al. 2022

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Background: Metabolic syndrome (MS) is highly prevalent in older adults; it constitutes a risk factor for cognitive deterioration, frailty, and Alzheimer’s disease. For this reason, the WHO has pointed out the importance of the implementation of community programs for the training of healthy aging. The aim of this study was to evaluate the effect of a community gerontology program framed in active aging on the control of metabolic syndrome in older adults. Methods: An experimental study was carried out in a convenience sample of 80 older adults diagnosed with MS according to the ATPIII criteria, comprising (1) experimental group (EG), n = 40; (2) control group (CG), n = 40. During a 6-month period, the EG participated in a supervised community gerontology program, and the CG was assessed monthly. Results: A statistically significant decrease was observed in the number of components for the diagnosis of MS. In this regard, of the total of participants with a diagnosis of MS in EG, only 28% maintained the diagnosis of MS (ATPIII ≥ 3 criteria), in contrast to 83% of the CG participants (p < 0.0001). Conclusions: Our findings suggest that health self-care training within the framework of active aging is effective for the control of MS in older adults.

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Section: Discussionmentioning

confidence: 99%

Effect of a Community Gerontology Program on the Control of Metabolic Syndrome in Mexican Older Adults

et al. 2022

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“…Regarding the geographical setting, 10 of the studies were conducted in European countries, namely France (24,(30)(31)(32)38), United Kingdom (28), Finland (19,29), Spain (33), and the Netherlands (36). Six studies were conducted in the United States (22, 25-27, 34, 37), two studies in Australia (39, 40), one study in Brazil (35), and three studies in Asia, with one study in Taiwan (23), one in Indonesia (21), and one in China (20). Figure 2 provides a graphical representation of the distribution of the geographical areas covered by the studies included in the review.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Furthermore, Lassale et al (28) found that in individuals aged between 47 and 87 years at baseline, increasing CRP levels over the course of 10 years of follow-up presented lower odds for SA than those that had stable low CRP trajectories. In a more recent study, Lin et al (23) explored the association of the metabolic syndrome and its components (central obesity, elevated blood glucose, low high-density lipoprotein cholesterol, and hypertension) with SA. The results supported the previously reported link between metabolic health and SA, showing that it may be important not only for physical health, but also may determine psychological well-being.…”

Section: Biological Factorsmentioning

confidence: 99%

Determinants and indicators of successful aging as a multidimensional outcome: a systematic review of longitudinal studies

Rodrigues,

Grandt,

Alwafa

et al. 2023

Front. Public Health

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BackgroundSuccessful aging (SA) has been coined as a term to describe the multidimensional aspects associated with achieving optimal combination of physical and mental health along with social well-being health, mental and social well-being at older age. In recent years there has been an increased interest in understanding the role of determinants of SA, such as demographic, biological, behavioral, psychological and social factors. To synthesize the recent evidence, we conducted a systematic review of longitudinal studies on a range of determinants and indicators of SA defined as a multidimensional outcome.MethodsA systematic search of PubMed, MEDLINE and Web of Science for finding eligible papers published between August 2016 and June 2023 was conducted following the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) guidelines. The review protocol was registered in PROSPERO International Prospective Register of Systematic Reviews (Registration number: CRD42021250200). The web-based automated screening tool–Rayyan–was used for title and abstract screening. The study quality was assessed using the Quality in Prognosis Studies (QUIPS) tool.ResultsA total of 3,191 records were initially identified using the predefined search strategy. Out of 289 articles selected for full text screening, 22 were found eligible and included in the review. A variety of factors have been explored in relation to SA, ranging from socio-demographic factors, nutrition, lifestyle, biological pathways, psychological health, and well-being. Overall, the results of recent studies have confirmed the role of metabolic health, adherence to healthy dietary patterns, such as the Mediterranean diet, physical activity, non-smoking, and higher socio-economic status as main factors associated with higher odds for SA. Emerging research highlights the role of psycho-social factors and early life health as determinants of SA.ConclusionIn summary, this review highlights the importance of healthy living and monitoring metabolic risk along with sustaining psychological well-being in adult life as major determinants of SA. Further methodological and research work on SA would pave the way toward development of adequate health promotion policies in aging societies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021250200, CRD42021250200.

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“…There is evidence that ageing, and obesity are interrelated and may influence each other [5,6]. An increase in body weight can trigger the processes of accelerated ageing and thus contribute to the progression of metabolic and age-associated diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Influence of obesity on biological age in patients with arterial hypertension

Kolesnikova,

Zaprovalna,

Bondar

et al. 2023

Arterial Hypertension

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Background:The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension. Materials and methods: One hundred sixteen patients (the age 35-65 years, women 62.3%) with stage 1-2 grade 1-2 hypertension and low/moderate cardiovascular risk (CVR) were included in the study. 34 patients (27.59%) were obese, 50 patients (43.1%) were overweight, 32 patients (29.31%) had normal weight. Anthropometric, clinical, biochemical and molecular genetic methods (relative telomere length (RTL-b), telomerase activity (TA) and 5-methylcytosine global methyl level (GML) in DNA of blood mononuclear cells) were used. Epigenetic age was calculated using the DNAm PhenoAge epigenetic clock. Results:The increase markers of carbohydrate metabolism [glycated haemoglobin (HbA 1c ), fasting plasma glucose (FPG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR)], changes of lipid metabolism indicators [an increase in triglycerides (TG) and a decrease in high-density lipoprotein cholesterol (HDL)] were revealed in the obese group, compared with the normal weight group (p < 0.05). We didn't find differences in RTL-b in any groups (p > 0.05). But at the same time obese patients had higher GML and lower TA (p < 0.05). The accelerated ageing (by DNAm PhenoAge epigenetic clock) was association with higher visceral fat%, higher levels, TG, very low-density lipoprotein cholesterol, all parameters of carbohydrate metabolism (HbA 1c , FPG, Insulin, HOMA-IR) and lower HDL-C (p < 0.05). Conclusions: Pathological weight gain associated with the progression of metabolic disorders and accelerated ageing in patients with hypertension and low/moderate cardiovascular risk.

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The association between metabolic syndrome and successful aging- using an extended definition of successful aging

Cited by 9 publications

References 49 publications

Effect of a Community Gerontology Program on the Control of Metabolic Syndrome in Mexican Older Adults

Effect of a Community Gerontology Program on the Control of Metabolic Syndrome in Mexican Older Adults

Determinants and indicators of successful aging as a multidimensional outcome: a systematic review of longitudinal studies

Influence of obesity on biological age in patients with arterial hypertension

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