The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Sánchez, Otto A.; Duprez, Daniel; Daniels, Lori B.; Maisel, Alan S.; Otvos, James D.; Peralta, Carmen A.; Lima, João A.C.; Bahrami, Hossein; Jacobs, David R.

doi:10.1016/j.metabol.2015.04.001

Cited by 6 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NT-proBNP and BNP levels are inversely correlated with BMI in the general population and obese individuals have typically lower BNP concentrations independent of cardiovascular disease (CVD) [ 9 , 10 ]. A recent study further revealed that BNP within the reference range (< 100 ng/L) was inversely correlated with total cholesterol, non-HDL cholesterol, and non-fasting triglycerides representing a favorable lipoprotein profile confirming an observation from a number of previous studies [ 11 – 13 ]. In contrast, in CVD—for which dyslipidemia is a well-known risk factor [ 14 ]—NT-proBNP or BNP levels are typically elevated.…”

Section: Introductionsupporting

confidence: 77%

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

Masuch

Pietzner

Bahls

et al. 2018

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundThe N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an important biomarker for the diagnosis of heart failure. Apart from this and only recently recognized, NT-proBNP levels associate with higher HDL- and lower LDL-cholesterol levels comprising a favorable blood lipid profile. To further examine this observation, the lipoprotein profile in relation to NT-proBNP was examined in-depth by proton nuclear magnetic resonance spectroscopy (1H-NMR). We complemented this investigation with a state-of-the-art untargeted metabolomics approach.MethodsLipoprotein particles were determined by 1H-NMR spectroscopy in 872 subjects without self-reported diabetes from the population-based Study of Health in Pomerania (SHIP)-TREND with available NT-proBNP measurements. Comprehensive metabolomics data for plasma and urine samples were obtained. Linear regression models were performed to assess the associations between serum concentrations of NT-proBNP and the metabolites/lipoprotein particles measured in plasma or urine.ResultsAn increase in serum NT-proBNP was associated with a benefical lipoprotein profile, including a decrease in VLDL, IDL and LDL-particles along with an increase in large HDL particles. These findings were replicated in a second independent cohort. Serum concentrations of NT-proBNP showed significant inverse associations with seven plasma metabolites while associations with 39 urinary metabolites, mostly comprising amino acids and related intermediates, were identified. Mediation analyses revealed adiponection as mediating factor for the associations observed with lipoproteins particles.ConclusionsMost of the metabolic changes associated with NT-proBNP implicate significant influence on the blood lipid profile besides vasodilatory and the diuretic action of BNP signaling. Our data suggest that the more favorable lipoprotein profile as associated with elevated NT-proBNP concentrations in mainly cardiac healthy individuals might relate to adiponectin signaling indicating even indirect cardio-protective effects for NT-proBNP.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0765-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionsupporting

confidence: 77%

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

Masuch

Pietzner

Bahls

et al. 2018

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…33 Comparison of the upper versus the lowest three sextiles of baseline NT-proBNP was associated with a 32% lower adjusted risk of this outcome, but attenuation of the association occurred at levels toward the upper limit of the fifth sextile (>150 pg/ml), 33 consistent with similar flattening of NT-proBNP’s associations with metabolic risk factors as concentrations reached a higher range. 11, 12 The same study 33 reported a U-shaped association for subsequent 3-year interval change in NT-proBNP and diabetes. Taken together with the ARIC results, these findings are consistent with the adverse metabolic impact of pathologic elevations of NT-proBNP into the higher range, as compared with physiologic elevations.…”

Section: 0 Discussionmentioning

confidence: 90%

“…NP receptors are expressed in adipose tissue and skeletal muscle, and NPs have been shown to promote adipocyte browning, foster adipokine secretion and increase oxidative capacity in muscle. 3–8 In clinical studies, higher levels of N-terminal proBNP (NT-proBNP), a cleavage product of proBNP, are associated with less obesity and metabolic syndrome, 9–12 and a decreased risk of incident type 2 diabetes. 13–16 Moreover, studies of genetic variants in the natriuretic peptide precursor A ( NPPA ) and B ( NPPB ) loci suggest that mild, lifelong elevations in natriuretic peptides may protect against type 2 diabetes.…”

Section: 0 Introductionmentioning

confidence: 99%

Longitudinal assessment of N-terminal pro-B-type natriuretic peptide and risk of diabetes in older adults: The cardiovascular health study

et al. 2016

View full text Add to dashboard Cite

Introduction Natriuretic peptides have a well-recognized role in cardiovascular homeostasis. Recently, higher levels of B-type natriuretic peptide (BNP) have also been associated with decreased risk of diabetes in middle-aged adults. Whether this association persists into older age, where the pathophysiology of diabetes changes, has not been established, nor have its intermediate pathways. Methods We investigated the relationship between N-terminal (NT)-proBNP and incident diabetes in 2359 older adults free of cardiovascular disease or chronic kidney disease in the Cardiovascular Health Study. Results We documented 348 incident cases of diabetes over 12.6 years of median follow-up. After adjusting for age, sex, race, body mass index, systolic blood pressure, anti-hypertensive treatment, smoking, alcohol use, and LDL, each doubling of NT-proBNP was associated with a 9% lower risk of incident diabetes (HR=0.91 [95% CI: 0.84–0.99]). Additional adjustment for waist circumference, physical activity, estimated glomerular filtration rate or C-reactive protein did not influence the association. Among putative mediators, HDL and triglycerides, adiponectin, and especially homeostasis model assessment of insulin resistance, all appeared to account for a portion of the lower risk associated with NT-proBNP. Conclusion In older adults without prevalent cardiovascular or kidney disease, higher NT-proBNP is associated with decreased risk of incident diabetes even after adjustment for traditional risk factors. These findings suggest that the metabolic effects of natriuretic peptides persist late in life and offer a potential therapeutic target for prevention of diabetes in older people.

show abstract

“…Obesity is associated with cardiovascular diseases; however, BNP and NT-proBNP levels are paradoxically reduced in obese subjects and a negative linear relationship between body mass index (BMI) and both BNP and NT-proBNP levels has been consistently reported in epidemiological studies [ 7 – 9 ]. Recently, this inverse association has been also confirmed in morbid obese subjects [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Short term variation in NTproBNP after lifestyle intervention in severe obesity

et al. 2017

View full text Add to dashboard Cite

AimNatriuretic peptides are not only involved in cardiovascular adaption to various conditions, but also in metabolic diseases. We performed this study to assess the effect of a very short time of lifestyle inpatient intervention on NTproBNP values in normotensive subjects with severe obesity and normal cardiac function.MethodsWe recruited 14 consecutive obese normotensive subjects with normal cardiac function who were aged 30 years and more and were referred to inpatient rehabilitation in an academic clinic over a two months period. They were examined at baseline and after a 3-weeks program including dietary intervention with hypocaloric diet and assisted personalized physical aerobic and anaerobic activities and compared to age, sex and BMI-matched control subjects under usual care.ResultsBMI significantly decreased (40.8 ±1.6 vs 42.3 ± 1.6 kg/m2, p <0.0001). Median reduction in body weight was 4.9 kg (interquartile range 2.4–5.2 kg). After diet and exercise-induced weight loss, plasma NTproBNP levels showed an almost two-fold increase, which was statistically significant (28.2 ± 12.3 vs 17.2 ± 13.2 ng/L, p = 0.01), and particularly relevant in the subgroup with NT-proBNP values below median values compared to those with higher values (p = 0.02). No significant variations were found in control subjects (18.0 ± 13.0 vs 16.5 ± 11.2 ng/L, p = 0.18). The lipid profile was significantly ameliorated, and both HbA1c and insulin levels showed a marginally non-significant decrease after treatment.ConclusionsAn almost two-fold increase in NTproBNP levels was evident after a very short time period of lifestyle intervention in normotensive severe obese patients without cardiac disease. This finding might have clinical relevance, considering the role of NT-proBNP as risk factor of impaired glucose tolerance.

show abstract

The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Cited by 6 publications

References 28 publications

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

Longitudinal assessment of N-terminal pro-B-type natriuretic peptide and risk of diabetes in older adults: The cardiovascular health study

Short term variation in NTproBNP after lifestyle intervention in severe obesity

Contact Info

Product

Resources

About