The Association between Non-Alcoholic Fatty Liver Disease and Dynapenia in Men Diagnosed with Type 2 Diabetes Mellitus

Abstract

Background: Dynapenia and non-alcoholic fatty liver disease (NAFLD) are common, especially in the middle and advanced-age diabetic male population. We aimed to examine the clinical features, NAFLD severity, and parameters associated with the presence of dynapenia in type 2 diabetes mellitus (T2DM) cases. Material and Methods: One hundred thirty-five male patients diagnosed with T2DM between 45 and 65 years of age were included. Patients were staged by ultrasonography according to NAFLD status. Results: There were significant differences in muscle strength, upper arm circumference, calf circumference, and up-and-go test scores between the mild-moderate-severe and non-NAFLD groups (p < 0.001 for all). The frequency of dynapenia was lower, and arm and calf circumferences were higher in patients without NAFLD. The muscle strength, upper arm circumference, calf circumference, and up-and-go test scores were significantly lower in the dynapenic group compared to the non-dynapenic group (p < 0.005 for all). The prevalence of dynapenia increased along with the increase in NAFLD stages (p < 0.001). Conclusions: We detected a significant association between NAFLD and dynapenia in middle-aged men with T2DM. As muscle strength decreases, the amount of fat in the liver increases, and as the fat in the liver increases, muscle strength decreases.

The Correlation Between Leg Muscle Mass Index and Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

“…Insulin can accelerate protein synthesis, and its breakdown can The loss of muscle mass reduces exercise tolerance, which can result in obesity (particularly the buildup of visceral fat), 17 and increase the risk of NAFLD. 18 By altering the metabolism of fat muscles and IR, loss of muscle mass and obesity primarily encourage lipotoxic effects and have a negative impact on NAFLD onset and progression. 19 Sarcopenia and obesity increase the risk of NAFLD 20 and all-cause mortality compared to obesity alone.…”

Association of low muscle strength with metabolic dysfunction-associated fatty liver disease: A nationwide study

“…To the best of our knowledge, no prior studies have examined the association between muscle strength and the risk of MAFLD. However, few studies have examined the association between muscle strength and NAFLD[ 31 ]. One cross-sectional study, utilizing data from the KNHANES database, found an association between low muscle strength and NAFLD[ 8 ].…”