The Association Between p53 Codon 72 Polymorphism and Endometrial Cancer Risk: A System Review and Meta-analysis

Abstract

Polymorphism of p53 codon 72 plays an important role in pathogenesis and development of cancer. Published data on the association between the p53 codon 72 polymorphism and endometrial cancer risk are controversial. A meta-analysis was performed to assess whether the polymorphism of p53 codon 72 is associated with endometrial cancer risk. Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for p53 codon 72 polymorphism and endometrial cancer were appropriately derived from fixed-effects or random effects models. A total of 12 studies were enrolled in this meta-analysis. The pooled analyses revealed that p53 codon 72 polymorphism was not associated with endometrial cancer risk. Stratified analysis by Hardy-Weinberg equilibrium exhibited a significantly increased risk of endometrial cancer among studies deviated from Hardy-Weinberg equilibrium in heterozygote comparison (Pro/Arg vs Arg/Arg; OR, 0.61; 95% CI, 0.42-0.87) and dominant model (Pro/Pro + Pro/Arg vs Arg/Arg; OR, 0.66; 95% CI, 0.47-0.92). This study indicated that the p53 codon 72 polymorphism may not be associated with endometrial cancer risk.

Both p53 codon 72 Arg/Arg and pro/Arg genotypes in glioblastoma multiforme are associated with a better prognosis in bevacizumab treatment

“…Many case-control studies have investigated the association between p53 codon 72 Pro/Arg polymorphism, but those studies have provided inconsistent findings. Nonetheless, more and more meta-analysis evidence obtained by pooling all the currently available case-control studies to estimate the effect and distribution of p53 codon 72 Arg/Pro polymorphism on cancer susceptibility has indicated that the polymorphism is not associated with overall cancer odds in several populations, including Iranian [ 41 ] and Chinese [ 42 ] colorectal cancer patients [ 43 ]. However, others studies have indicated the opposite, that is, that the polymorphism is associated with increased risk of several malignancies associated with viral infections, including in Caucasian (prostate cancer) [ 44 ], European (high-grade glioma; Pro 72) [ 45 ], Indian (cervical cancer) [ 46 ], Chinese (cervical cancer) [ 47 ], and Japanese (hepatocellular carcinoma) populations [ 48 ], implying that important ethnic and tumor type differences may exist regarding the cancer susceptibility of p53 codon 72 polymorphisms.…”

The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients

“…The proline variant of p53 acts as a more robust activator of transcription factors but exhibits less potent apoptotic properties than the arginine variant, which is more prone to degradation [5]. This polymorphism at p53's 72nd codon is posited to play a crucial role in cancer development and pathogenesis [6].…”