The association between paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome

Gu, Heng-Fang; Mou, Meng; Liang, Zhenwen; Sun, Chengxin; Ren, X. Y.; Xiao, Yuqing

doi:10.14715/cmb/2016.62.14.7

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…Since the increase in triglyceride level and decrease in HDL are important risk factors for obesity, insulin resistance and body mass index, it can be concluded that the change of these parameters in TT genotypes can play an effective role in development of PCOS in humans. In this study, patients with PCOS had a significant increase in testosterone and a decrease in Luteinizing Hormone (LH) compared to controls, which is consistent with the results of previous studies [4,31,32] abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP.…”

Section: Discussionsupporting

confidence: 92%

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Sahmani

Ghaleh

Yargholi

et al. 2020

JQUMS

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Background: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods: In this case-control study, participants were 106 women with PCOS and 114 healthy women referred to Kosar Hospital in Qazvin, Iran. The TNF-α gene’s polymorphism was determined using Polymerase Chain Reaction (PCR) technique and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Biochemical factors of serum levels were also measured in two groups. Logistic regression analysis examined the relationship between the frequency of alleles in different states and the risk of PCOS. Findings: There were statistically significant difference in the mean levels of total cholesterol, triglycerides, testosterone, two-hour blood glucose and body mass index between the groups, whose values were higher in women with PCOS compared to healthy women (P<0.001). In women with PCOS, the mean serum levels of triglyceride and high-density lipoprotein were significantly different between the three TT, CC, TC genotypes of TNF-α gene polymorphism (P<0.05). The results of regression analysis showed that the TT genotype had significant association with the risk of PCOS (OR=2.43, P=0.006, 95%CI: 1.28-2.62). Conclusion: It seems that there is a relationship between the -1301 (T/C) polymorphism of TNF-α gene and the risk of PCOS in women.

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Section: Discussionsupporting

confidence: 92%

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Sahmani

Ghaleh

Yargholi

et al. 2020

JQUMS

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“…Two investigators (AK and NP) independently extracted data and arrived at consensus. The following information was obtained from each publication: indications (yes/no) of whether each article was included in the four previous meta-analyses [18][19][20][21], first author's name, published year, country of origin, ethnicity, diagnostic criteria, PON SNVs examined and article features needed to tally the Clark-Baudouin score. Table S1 shows the rs numbers (SNVs per study), values under cases and controls that include sample sizes and genotype frequencies as well as minor allele frequencies and P-values for the Hardy-Weinberg Equilibrium (HWE).…”

Section: Data Extractionmentioning

confidence: 99%

“…Table 1 shows which studies were and were not included in the four previous meta-analyses [18][19][20][21]. Three articles [47][48][49] were new additions to the meta-analysis literature and account for the updated associations between PON variants and PCOS.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…However, associations of the PON SNVs with PCOS risk have been contradictory, which gives reason to perform a meta-analysis of all eligible studies. Since the four previous meta-analyses [18][19][20][21], new primary studies have emerged. We provide a more comprehensive analysis and arrive at a reliable conclusion by reevaluating the associations of the PON SNVs with PCOS risk.…”

Section: Introductionmentioning

confidence: 99%

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Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Kunjantarachot

Pabalan

Jarjanazi

et al. 2020

Reprod Biol Endocrinol

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Background Etiology of polycystic ovary syndrome (PCOS) is attributed to genetic and environmental factors. One environmental factor is oxidative stress. Paraoxonase 1 (PON1) is an antioxidant high-density lipoprotein-associated enzyme encoded by the PON1 gene. The PON1 gene has been implicated in the risk for PCOS, the influence of which appears to come from single nucleotide variants (SNVs) at multiple genetic loci. However, association study reports have been inconsistent which compels a meta-analysis to obtain more precise estimates. Methods From 12 publications, extracted genotype data were used in two genetic procedures. First, linkage disequilibrium (LD) was used to group eight PON SNVs into three: LD1, LD2 and LD3. Second, frequencies of the variant (var), wild-type (wt) and heterozygous (het) genotypes were used for genetic modeling (allele-genotype for LD1 and standard for LD2 and LD3). Risk associations were expressed in terms of pooled odds ratios (ORs), 95% confidence intervals (CIs) and Pa-values. Evidence was considered strong when significance was high (Pa < 0.0001) and heterogeneity absent (I2 = 0%). Pooled effects were subjected to modifier (power), subgroup (Asian/Caucasian), outlier, sensitivity and publication bias treatments. Multiple comparisons were Bonferroni-corrected. Results This meta-analysis generated 11 significant outcomes, five in LD1, six in LD2 and none in LD3. All six LD2 outcomes did not survive the Bonferroni-correction but two of the five in LD1 did. These two core LD1 findings conferred greater odds of PCOS to the var allele in the highly significant (Pa < 0.0001) overall (OR 1.44, 95% CI 1.24–1.67) and Asian (OR 1.41, 95% CI 1.20–1.65) outcomes. Of these two core outcomes, the Asian effect was homogeneous (I2 = 0%) but not the overall (I2 = 29%). Conclusions Of the eight PON SNVs examined, two (rs854560 and rs662) were associated with PCOS risk. These 1.4-fold increased risk effects rendered Asians susceptible to PCOS. High statistical power, high significance, zero to low-level heterogeneity, robustness and lack of bias in the core outcomes underpinned the strong evidence for association.

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“…[18,19] Various polymorphisms within the PON1 gene have been found to be associated with a number of diseases, via changes in enzymatic activity and serum level, notably polycystic ovary syndrome, diabetes mellitus, hypertension, anti-phospholipid syndrome, systemic lupus erythematosus, coronary artery disease, rheumatoid arthritis, renal failure, and macular degeneration. [19][20][21][22][23] Chronic inflammation is a feature of many such diseases, including, of course, COM.…”

Section: Introductionmentioning

confidence: 99%

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Durmuş¹,

Kurtulgan²,

Bora³

et al. 2019

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Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation w hich l ies a t t he h eart of t he d isorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department of Cumhuriyet University and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) -restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism.Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion:The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group may indicate a protective effect in COM.

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The association between paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome

Cited by 6 publications

References 13 publications

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

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