The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany

Kouka, Mussab; Hermanns, Isabel; Guntinas‐Lichius, Orlando

doi:10.3390/cancers15061780

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Men are about 3 times more likely than women to develop a head and neck cancer, mainly due to higher smoking and drinking rates.. The study also supported by (Kouka et al, 2023) who reported that Patients with head and neck cancer (HNC) are nearly 60% already over 60 years old and, approximately 70% are over 65 years and 50% over 70 years old.…”

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confidence: 67%

Factors Affecting Thyroid Dysfunction in Patients with Head and Neck Cancer Receiving Chemo-radiation Therapy

shehata Elsayed Harby,

Abdelmowla Ahmed,

Arafa Gomaa

2023

Egyptian Journal of Health Care

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Background: Head and neck cancers are considered the 6th most common cancer worldwide. For patients with advanced disease, combined modality treatment including chemo-radiation (CRT) as first-line treatment had improved outcomes for patients with locally advanced disease. The association between radiation exposure and the occurrence of thyroid cancer has been well documented, and the two main risk factors for the development of thyroid cancer are the radiation dose delivered to the thyroid gland and the age at exposure. The risk increases after exposure to a mean dose of more than 0.05-0.1 Gy (50-100 mGy. Nurses' role is not only in the maintenance of the treatment and its adverse effects, but also to act as information disseminators about the disease and its treatment, offering relief measures and helping the patients to cope with the disease Aim: Assess factors affecting thyroid dysfunction in patients with head and neck cancer receiving radiation or chemo-radiation therapy. Design: A descriptive research design was utilized for this study to meet the aim of the present study. Setting: chemotherapy and radiology units of the Main University Hospital and Charity Ayadi Almostakbl center for cancer treatment in Alexandria.. Subjects: A convenience sample of 100 adult male and female patients. Study tools: Three tools were used. Tool (I) A socio-demographic and clinical data interview schedule, Tool (II) Assessment of head and neck cancer patient's knowledge and Tool (III) Assessment of chemo-radiation side effects on thyroid gland structured interview schedule. Results: The current study showed that there was statistical significant difference between sociodemographic characteristics and clinical data and patients overall Knowledge score and all over sign and symptoms.. Conclusion: The provision of effective education was found to have a profound impact on improving patients' knowledge and practice. Recommendations: Regular testing of thyroid function in patients undergoing radiation or chemo radiation can help in diagnosing thyroid dysfunction at the subclinical stage, before it progresses to clinical hypothyroidism. Larger multi-institutional studies with longer follow-up are needed to study the morbidity associated with post radiation thyroid dysfunction further.

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confidence: 67%

Factors Affecting Thyroid Dysfunction in Patients with Head and Neck Cancer Receiving Chemo-radiation Therapy

shehata Elsayed Harby,

Abdelmowla Ahmed,

Arafa Gomaa

2023

Egyptian Journal of Health Care

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Impact of Age in Single‐Level Versus Multilevel Airway Compromise: A Multi‐Institutional Review

Laohakittikul,

Khalsa,

Rao

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveExamine the association between age and treatment outcomes in conditions causing single‐ versus multilevel airway restriction.Study DesignMulti‐institutional retrospective cohort study.SettingTertiary laryngology centers.MethodsParticipants included younger (18‐64 years) and geriatric (≥65 years) adults with posterior glottic stenosis (PGS), multilevel airway stenosis (MLAS), and bilateral vocal fold paralysis (BVFP). Subgroup demographics, comorbidities, type, and etiology of airway compromise were described. Associations between age and primary outcome variables (i.e., tracheostomy and decannulation rates, number of surgeries performed, time between surgeries, and change in quality‐of‐life patient‐reported outcome measures [PROMs]) were evaluated. Statistical analyses included independent t tests, χ2, Fisher's exact, or Mann‐Whitney tests.ResultsIn 158 patients [96 younger (30 PGS, 29 MLAS, 37 BVFP) and 62 geriatric (24 PGS, 9 MLAS, 29 BVFP)], age differences were not significant for gender (P = .990), tracheostomy placement (70% vs 66%, P = .629), or decannulation success (40% vs 24%, P = .091) in younger versus geriatric groups, respectively. In younger patients, MLAS was more common (30.2% vs 14.5%, P = .024), and BVFP patients were more likely to decannulate (50% vs 12%, P = .017). Geriatric patients were more likely to have a history of prior radiation (26% vs 10%, P = .016), stenosis due to malignancy (23% vs 9%, P = .022), and fewer overall surgeries (median 1 vs 3, P = .003). Median PROMs were comparable between age subgroups (P > .05).ConclusionYounger adults underwent more surgeries, but overall comorbidities, tracheostomy decannulation rates, and PROMs were comparable between groups. Age does not negatively impact treatment outcomes and should not be a deterrent in treatment decision‐making.

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Assessing the Association Between Head and Neck Cancer and Granulomatosis with Polyangiitis

Hoying,

Dorney,

Otteson

et al. 2024

Ear Nose Throat J

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Objective: To determine the odds of head and neck cancer (HNC) in patients with a concurrent or prior diagnosis of granulomatosis with polyangiitis (GPA). Methods and Materials: The TriNetX Analytics Network, a federated research platform that aggregates de-identified electronic health record data of over 130 million patients worldwide, was queried for patients with at least one ICD-10 encounter diagnosis of GPA. Patients within this group with an encounter diagnosis of cancer of the sinonasal, oral cavity, oropharynx, nasopharynx, and larynx concurrent or after the initial encounter diagnosis of GPA were recorded and compared to a standardized control population to determine odds ratios with a 95% confidence interval (CI). Relevant confounding variables, including human papillomavirus, Epstein Barr virus, tobacco, and alcohol exposure, were balanced between cohorts by 1:1 propensity matching. Results: Of the patients in the GPA cohort, 126 (0.48%) had an ICD-10 diagnosis of HNC. When stratifying by head and neck subsites, 20 (0.08%), 18 (0.07%), 23 (0.09%), 70 (0.27%), and 22 (0.084%) GPA patients had an ICD-10 encounter diagnosis of cancer involving the sinonasal, nasopharynx, larynx, oral cavity, and oropharynx. When comparing the experimental GPA group with the standardized control population after matching, patients in the GPA group had 1.3 times (95% CI: 1.03-1.175) greater odds of HNC when including cases diagnosed after or concurrently with the diagnosis of the vasculitis. There was no statistical difference in the odds of cancer at each anatomical subsite between the GPA and control cohort after matching. Conclusion: Our study identifies a statistically significant increase in the odds of HNC encounter diagnoses in patients with GPA.

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The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany

Cited by 4 publications

References 33 publications

Factors Affecting Thyroid Dysfunction in Patients with Head and Neck Cancer Receiving Chemo-radiation Therapy

Factors Affecting Thyroid Dysfunction in Patients with Head and Neck Cancer Receiving Chemo-radiation Therapy

Impact of Age in Single‐Level Versus Multilevel Airway Compromise: A Multi‐Institutional Review

Assessing the Association Between Head and Neck Cancer and Granulomatosis with Polyangiitis

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