The association between plasma fibrinogen levels and lung cancer: a meta-analysis

Zhang, Ke; Xu, Ye; Tan, Shanyue; Wang, Xueyan; Du, Mulong; Liu, Lingxiang

doi:10.21037/jtd.2019.11.13

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Furthermore, a multicenter prospective study on 395 patients with operable NSCLC showed that some elevated preoperative coagulation factors, such as fibrinogen, may have a significant effect on poor progression‐free survival and can be used to predict the prognosis of patients with NSCLC after surgery 19 . Even in a meta‐analysis of the association between plasma fibrinogen levels and lung cancer, plasma fibrinogen was considered a marker of prognosis and associated with distant metastasis and tumor stage 20 . This study focused on whether fibrinogen is a prognostic factor in patients with resected stage I NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…19 Even in a meta-analysis of the association between plasma fibrinogen levels and lung cancer, plasma fibrinogen was considered a marker of prognosis and associated with distant metastasis and tumor stage. 20 This study focused on whether fibrinogen is a prognostic factor in patients with resected stage I NSCLC. Further, we recently found that elevated fibrinogen level was a significant prognostic factor even in stage I NSCLC.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of preoperative plasma fibrinogen levels in resected stage I non‐small cell lung cancer

et al. 2022

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Background: The number of surgical procedures has increased among patients with early-stage lung cancer. If the poor prognostic factors for stage I non-small cell lung cancer (NSCLC) can be simply validated preoperatively, appropriate treatment will be provided. The current study aimed to evaluate the prognostic value of preoperative plasma fibrinogen levels in patients with resected stage I NSCLC. Methods: We retrospectively analyzed the clinicopathological information of patients (n = 149) who underwent lobectomy for stage I NSCLC between May 2014 and July 2016. Data about peripheral blood analysis, histopathological finding, and follow-up assessment results were collected from the databases. Patients were divided into the low and high fibrinogen groups. Univariate and multivariate analyses were performed to evaluate the predictors of recurrence and survival. Results: Compared with the low fibrinogen group (<377 mg/dl), the high fibrinogen group (≥377 mg/dl) had a significantly greater number of male participants (p = 0.04), smokers (p < 0.001), and those with elevated cytokeratin antigen levels (p = 0.04), lymphatic invasion (p = 0.007), and squamous cell carcinoma (p < 0.001). Plasma fibrinogen level was considered a significant independent factor for recurrence and overall survival on both the univariate and multivariate analyses (p < 0.001 and p = 0.010) and the multivariate analysis alone (p = 0.020 and p < 0.012). Conclusion: Preoperative plasma fibrinogen level might be a useful predictor of recurrence and survival in patients with stage I NSCLC. The treatment strategy for patients with high fibrinogen levels could be cautiously considered preoperatively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative plasma fibrinogen levels in resected stage I non‐small cell lung cancer

et al. 2022

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“…Consequently, peripheral blood coagulation parameters, which mirror the systemic coagulation state, hold promise as potential indicators for tumor risk stratification. The levels of coagulation markers have been found to be significantly correlated with the clinicopathological features of malignancies, such as gastric cancer, breast cancer, and lung cancer 11 – 13 . However, a paucity of research has investigated the correlation between coagulation markers and the clinicopathological features of PCa.…”

Section: Introductionmentioning

confidence: 99%

Coagulation markers as independent predictors of prostate cancer aggressiveness: a retrospective cohort study

Lei,

Zhang,

Deng

et al. 2023

Sci Rep

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Coagulation system activation is commonly observed in tumor patients, including prostate cancer (PCa), with coagulation markers proposed as potential prognostic indicators for cancer severity. However, the correlation between these markers and clinicopathological features in PCa remains unclear. Thus, this study investigates the association between comprehensive coagulation markers and clinicopathological characteristics in PCa patients. A retrospective evaluation of 162 PCa patients diagnosed and categorized into low-intermediate-risk or high-risk groups based on clinical and pathological features was conducted. Coagulation markers, including fibrinogen (FIB), d-dimer (DD), activated partial thromboplastin time (APTT), prothrombin time (PT), prothrombin activity (PTA), thrombin time (TT), platelet count (PLT), and international normalized ratio (INR), were assessed. Univariate and multivariate logistic regression analyses were performed to determine associations with clinicopathological features. FIB and DD were confirmed as independent factors associated with high-risk PCa. Furthermore, FIB and DD levels showed significant positive correlations with clinical parameters, including PSA levels, ISUP grade, T stage, N stage, and M stage. Our findings suggest that FIB and DD hold promise as independent prognostic biomarkers for risk stratification in PCa. These coagulation markers may aid in assessing PCa severity and guiding personalized treatment strategies.

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“…As a marker of systemic inflammation, PF is often associated with haemostasis and plays a key role in tumour research [ 21 , 22 ]. The pretreatment PF level has been shown to predict oncologic outcomes for digestive system tumours, lung carcinoma, gynaecologic carcinoma, and glioblastomas, but studies of its prognostic value in BC are lacking [ 18 , 23 , 24 , 25 ]. Additionally, at this stage, the potential molecular mechanism of PF affecting tumorigenesis remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of preoperative inflammation-based predictors in patients with bladder carcinoma after radical cystectomy

et al. 2021

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Aims Emerging evidence has related inflammation-based biomarkers to numerous carcinomas, including bladder carcinoma (BC). However, the role of inflammatory biomarkers in the prognosis of BC remains inconclusive. This study aimed to compare preoperative plasma fibrinogen (PF) and other inflammatory biomarkers such as the platelet–lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), C-reactive protein (CRP) level, and serum albumin level to predict the prognosis of patients with BC. Methods This article focused on a retrospective analysis of 175 patients with newly diagnosed BC who were admitted to our hospital from March 2005 to March 2016. Of these BC patients, 136 had undergone radical cystectomy (RC). Results According to multivariate analysis, high PF level was an independent predictor of overall survival (OS) in 136 BC patients receiving RC (HR = 3.759; P = 0.011), but not for all 175 BC patients. Combining the NLR and PF values showed higher predictive accuracy for OS than NLR or PF alone (P < 0.05). Additionally, for 136 BC patients who had undergone RC, a close relationship was found between high PF levels (≥3.39 g/L) and lymph node metastasis (P = 0.011) and clinical T stage (P = 0.015). Furthermore, PF was a superior prognostic factor compared with the LMR, PLR, CRP, and albumin values in 136 BC patients who had undergone RC (P < 0.001). Conclusions The preoperative PF level may be a prognostic biomarker; and when combined with the NLR, it can improve the predictive ability of the survival of BC patients, particularly of BC patients who underwent RC.

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The association between plasma fibrinogen levels and lung cancer: a meta-analysis

Cited by 9 publications

References 43 publications

Prognostic value of preoperative plasma fibrinogen levels in resected stage I non‐small cell lung cancer

Prognostic value of preoperative plasma fibrinogen levels in resected stage I non‐small cell lung cancer

Coagulation markers as independent predictors of prostate cancer aggressiveness: a retrospective cohort study

Prognostic value of preoperative inflammation-based predictors in patients with bladder carcinoma after radical cystectomy

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