The association between platelet indices, cognitive screening tests and functional dependence screening questionnaires in hospitalized older people

Socha, Krzysztof; Fife, Elizaveta; Kroc, Łukasz; Kostka, Tomasz

doi:10.1007/s41999-019-00214-z

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Besides older age and a higher number of diseases, lower platelet values increased the probability of transitions from MCI to the unclassifiable group, which consisted of individuals reporting a worsening of the general cognitive status, the activities of daily living and cognitive tests/functions, but who did not fall under the other categories. Studies currently available in the literature do not consistently support the association between platelets and cognitive function in older people, although activated platelets seem to play a substantial role in the pathogenesis of certain types of dementia, such as Alzheimer's disease (Catricala et al, 2012 ; Socha et al, 2019 ) and vascular dementia (Ahn et al, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

Trevisan

Siviero

Limongi

et al. 2022

Front. Aging Neurosci.

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Given the rising numbers of older people living with dementia, this study focuses on identifying modifiable health-related factors associated with changes in cognitive status. The predictors of 1-year conversion from Preserved Cognitive Health (PCH) and Mild Cognitive Impairment (MCI) in older adults were evaluated. Two logistic regression models were performed on data from an Italian multicenter population-based study; both included sociodemographic factors, family history of dementia (FHD), risk behaviors, and depressive symptoms. The first model considered also disease clusters, while the second one included diseases' number and biochemical parameters. The sample involved 459 participants (61.4% women, median age 75 years). Of the 80 PCH individuals at baseline, after 1 year 35 (43.8%) were stable, 44 (55.0%) progressed to MCI, none to dementia, and one to unclassified status. Of the 379 MCI participants at baseline, after 1 year 281 (74.1%) remained stable, 38 (10.0%) reverted to PCH, 15 (4.0%) progressed to dementia, and 45 (11.9%) become unclassifiable. Hypertension/bone and joint diseases cluster was the only predictor of PCH progression to MCI; age and depression were associated with MCI progression to dementia; FHD was associated with MCI reversion to PCH. More diseases and fewer white blood cells were associated with MCI progression to dementia; more diseases and lower platelets were associated with the transition from MCI to unclassifiable; higher Na and lower TSH levels were associated with MCI reversion. The treatment or management of some chronic conditions and electrolyte imbalances may help attenuate cognitive deterioration in older adults with no or MCI.

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Section: Discussionmentioning

confidence: 99%

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

Trevisan

Siviero

Limongi

et al. 2022

Front. Aging Neurosci.

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Platelet Dynamics in Neurodegenerative Disorders: Investigating the Role of Platelets in Neurological Pathology

Cadoni,

Coradduzza,

Congiargiu

et al. 2024

JCM

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Background: Neurological disorders, particularly those associated with aging, pose significant challenges in early diagnosis and treatment. The identification of specific biomarkers, such as platelets (PLTs), has emerged as a promising strategy for early detection and intervention in neurological health. This systematic review aims to explore the intricate relationship between PLT dynamics and neurological health, focusing on their potential role in cognitive functions and the pathogenesis of cognitive disorders. Methods: Adhering to PRISMA guidelines, a comprehensive search strategy was employed in the PubMed and Scholar databases to identify studies on the role of PLTs in neurological disorders published from 2013 to 2023. The search criteria included studies focusing on PLTs as biomarkers in neurological disorders, their dynamics, and their potential in monitoring disease progression and therapy effectiveness. Results: The systematic review included 104 studies, revealing PLTs as crucial biomarkers in neurocognitive disorders, acting as inflammatory mediators. The findings suggest that PLTs share common features with altered neurons, which could be utilised for monitoring disease progression and evaluating the effectiveness of treatments. PLTs are identified as significant biomarkers for detecting neurological disorders in their early stages and understanding the pathological events leading to neuronal death. Conclusions: The systematic review underscores the critical role of PLTs in neurological disorders, highlighting their potential as biomarkers for the early detection and monitoring of disease progression. However, it also emphasises the need for further research to solidify the use of PLTs in neurological disorders, aiming to enhance early diagnosis and intervention strategies.

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The association between platelet indices, cognitive screening tests and functional dependence screening questionnaires in hospitalized older people

Cited by 2 publications

References 43 publications

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals

Platelet Dynamics in Neurodegenerative Disorders: Investigating the Role of Platelets in Neurological Pathology

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