The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines

Behboudi‐Gandevani, Samira; Tehrani, Fahimeh Ramezani; Yarandi, Razieh Bidhendi; Noroozzadeh, Mahsa; Hedayati, Mehdi

doi:10.1007/s40618-017-0650-x

Cited by 45 publications

(29 citation statements)

References 27 publications

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“…The waist circumference and WHR partly reflect the distribution of body fat. The increase in abdominal fat releases a large number of free fatty acids, adipokines and cytokines that are closely related to IR . We did not find any correlation between the hirsutism score or acne score with FIN or HOMA‐IR.…”

Section: Discussioncontrasting

confidence: 58%

“…The increase in abdominal fat releases a large number of free fatty acids, adipokines and cytokines that are closely related to IR. 19,20 We did not find any correlation between the hirsutism score or acne score with FIN or HOMA-IR. A recent study 21 found that HOMA-IR was positively associated with FG score after adjustments for age, BMI, TT and the number of menses per year.…”

Section: Chinese Pcos Patients By the 'Modified Rotterdam Diagnosticmentioning

confidence: 57%

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Effect of hyperinsulinaemia and insulin resistance on endocrine, metabolic and fertility outcomes in women with polycystic ovary syndrome undergoing ovulation induction

Zhang

Yang

et al. 2019

Clinical Endocrinology

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Objective The aim of this study was to evaluate the effects of hyperinsulinaemia and insulin resistance (IR) on reproductive and metabolic disorders and fertility in women with polycystic ovary syndrome (PCOS). Design, Setting, Participants and Measurements This was a multicenter, randomized controlled trial involving a total of 1000 women diagnosed with PCOS according to the modified Rotterdam criteria at 21 sites (27 hospitals). We evaluated the effects of serum insulin levels and HOMA‐IR on parameters and outcomes. The main outcome measures were anthropometric, biometric and ultrasound parameters at baseline and the clinical outcomes of ovulation, conception, pregnancy, live birth and pregnancy loss. Results The relevant analysis between hyperinsulinaemia and IR and clinical characteristics showed that weight, waist and hip circumference, BMI, waist‐to‐hip ratio, acanthosis nigricans score and menstrual period were significantly correlated with fasting insulin (FIN) and HOMA‐IR. There was no significant correlation between the hirsutism score or acne score with FIN or HOMA‐IR. The relevant analysis between hyperinsulinaemia and IR and circulating sex steroids and gonadotrophins showed that FAI was significantly correlated with FIN and HOMA‐IR (r = 0.240, P < 0.001 and r = 0.191, P < 0.001, respectively). Free testosterone was significantly correlated with FIN after adjusting for the influence of age. LH and LH/FSH were not related to FIN or HOMA‐IR after statistical correction for differences in BMI. The relevant analysis between hyperinsulinaemia and IR and metabolic profile showed that FIN and HOMA‐IR were positively associated with fasting glucose, cholesterol, triglycerides, low‐density lipoprotein, Apo B, and the incidence of metabolic syndrome and were negatively associated with high‐density lipoprotein. The predictive analysis between hyperinsulinaemia and IR with fertility showed that the levels of FIN and HOMA‐IR were related to the fertility outcome (ovulation, pregnancy, conception or live birth) in patients with PCOS. After adjustments for age, total testosterone and free testosterone, increasing serum insulin levels and HOMA‐IR were significantly associated with decreased cycle ovulation, conception, pregnancy and live birth rates. Conclusions Hyperinsulinaemia and IR are associated with reproductive and metabolic disorders and can predict the fertility outcomes in PCOS patients.

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Section: Discussioncontrasting

confidence: 58%

Section: Chinese Pcos Patients By the 'Modified Rotterdam Diagnosticmentioning

confidence: 57%

Effect of hyperinsulinaemia and insulin resistance on endocrine, metabolic and fertility outcomes in women with polycystic ovary syndrome undergoing ovulation induction

Zhang

Yang

et al. 2019

Clinical Endocrinology

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“…A recent work confirmed that leptin serum concentrations are increased in obese women with PCOS, while adiponectin levels are decreased [94]. Furthermore, the authors suggested the higher leptin levels may be related to the hyperinsulinaemic characteristic of obesity and PCOS [94]. In this sense, as women with PCOS also commonly present overweight and obesity [95], the symptoms mentioned could be a consequence of the hyperleptinaemia due to the gain of fat mass.…”

Section: Leptin and Pathologies Associated With Pregnancymentioning

confidence: 87%

“…Different studies have shown augmented leptin levels in women with PCOS [91][92][93]. A recent work confirmed that leptin serum concentrations are increased in obese women with PCOS, while adiponectin levels are decreased [94]. Furthermore, the authors suggested the higher leptin levels may be related to the hyperinsulinaemic characteristic of obesity and PCOS [94].…”

Section: Leptin and Pathologies Associated With Pregnancymentioning

confidence: 93%

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Leptin action in normal and pathological pregnancies

Pérez-Pérez

Toro

Vilariño-García

et al. 2017

J Cellular Molecular Medi

163

159

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Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.

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Serum and follicular fluid chemerin and chemerin mRNA expression in women with polycystic ovary syndrome: Systematic review and meta‐analysis

Mansoori

Amoochi-Foroushani

Zilaee

et al. 2021

Endocrino Diabet & Metabol

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Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. Chemerin, a novel adipokine, is involved in inflammation, energy metabolism, adipogenesis, angiogenesis and insulin secretion in the adipose cells and ovary. This systematic review with meta‐analysis aimed to compare serum and follicular fluid (FF) chemerin and ovarian chemerin mRNA expression among women with PCOS and non‐PCOS. Methods Electronic databases including Web of Science, PubMed, Google Scholar, Scopus, Cochrane and CINAHL were used for a comprehensive search through April 2021. Of the 174 articles initially identified, 22 studies met the eligibility criteria. A random‐effects model with a weighted mean difference (WMD) and 95% confidence interval (CI) was performed to compare the outcomes between groups. Subgroup and sensitivity analyses were performed to detect the sources of heterogeneity. Results Women with PCOS compared to without PCOS showed significantly higher serum chemerin [WMD: 12.02 pg/ml (95% CI: [10.92, 13.13]), p < .001], chemerin mRNA expression [WMD: 0.38% (95% CI [0.25, 0.52]), p = .001] and FF chemerin [(WMD): 41.7 pg/ml (95% CI [17.89, 65.5]) p < .001]. Further, serum chemerin remained high in PCOS women even with subgroup analysis based on body mass index (BMI) or sample size (p < .001). Serum chemerin was higher in women with PCOS and higher BMI [(WMD): 3.29 pg/ml (95% CI: [2.73, 3.384]), p < .001]. The expression of chemerin mRNA was significantly higher in the PCOS group compared to the control group [WMD: 0.38% (95% CI [0.25, 0.52]), p < .001]. Conclusion Serum and FF chemerin and mRNA expression were higher in the PCOS group compared to the controls. Further, serum chemerin was higher in PCOS women with higher BMI compared to lower BMI. The present findings illustrate that chemerin may be associated with PCOS status and BMI, independently.

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The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines

Abstract: While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS.

Cited by 45 publications

References 27 publications

Effect of hyperinsulinaemia and insulin resistance on endocrine, metabolic and fertility outcomes in women with polycystic ovary syndrome undergoing ovulation induction

Effect of hyperinsulinaemia and insulin resistance on endocrine, metabolic and fertility outcomes in women with polycystic ovary syndrome undergoing ovulation induction

Leptin action in normal and pathological pregnancies

Serum and follicular fluid chemerin and chemerin mRNA expression in women with polycystic ovary syndrome: Systematic review and meta‐analysis

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