The association between preeclampsia and placental disruption induced by chorionic villous sampling

Farina, Antonio; Hasegawa, Junichi; Raffaelli, Simonetta S.; Ceccarini, Chiara; Rapacchia, Giuseppina; Pittalis, Maria Carla; Brondelli, Lorena; Righetti, Francesca; Rizzo, Nicola

doi:10.1002/pd.2528

Cited by 13 publications

(5 citation statements)

References 11 publications

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“…Farina et al . performed 106 transabdominal chorionic villus sample (CVS) between 11 and 13 weeks of pregnancy and they assessed the FMH by α‐fetoprotein and pregnancy‐associated placental protein‐A before and after the CVS.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of passage of fetal erythrocytes into maternal circulation after invasive obstetric procedures

Meleti

Oliveira

Júnior

et al. 2013

J of Obstet and Gynaecol

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Aim: The aim of this study was to evaluate the passage of fetal erythrocytes into the maternal circulation after invasive obstetric procedures, using the Kleihauer-Betke test, flow cytometry and a-fetoprotein concentration in maternal blood. Material and Methods:This was a prospective descriptive study on patients who underwent: amniocentesis, cordocentesis, chorionic villus sample, amniotic infusion, bladder drainage and ventricular-amniotic shunt to investigate the karyotype; treatment for hydrocephalus, oligohydramnios, obstructive uropathy and polyhydramnios; and investigation of lung maturity. Maternal blood samples were collected before and 60 min after the invasive obstetric procedure in order to evaluate the passage of fetal erythrocytes using the Kleihauer-Betke test, flow cytometry and a-fetoprotein concentration. Results: In total, 43 invasive obstetric procedures were performed. The procedures performed were: 27 cases of amniocentesis (62.7%), seven cases of cordocentesis (16.2%), four chorionic villus samples (9.4%), two amniotic infusions (4.7%), two ventricular-amniotic shunts and one bladder drainage (2.3%). After one case of cordocentesis with two puncture attempts via the placenta, a significant increase in fetal erythrocytes was detected using the three methods. After another cordocentesis with one puncture via the placenta, a significant increase in fetal erythrocytes was detected using flow cytometry and a-fetoprotein concentration, but not through the Kleihauer-Betke test. The other 41 samples did not show any significant increase in fetal erythrocytes in the maternal blood. Conclusion: Invasive obstetric procedures performed during prenatal care are safe when performed by experienced professionals with the proper technique, with minimal chance of passage of fetal erythrocytes into the maternal compartment.

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Section: Discussionmentioning

confidence: 99%

Evaluation of passage of fetal erythrocytes into maternal circulation after invasive obstetric procedures

Meleti

Oliveira

Júnior

et al. 2013

J of Obstet and Gynaecol

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“…Recently, some case reports described a possible association of FMH with other pregnancy and intrapartum events such as preeclampsia with well-known fetal DNA trafficking into the maternal circulation [11,12] or the placement of the intrauterine pressure catheter which is a common obstetrical procedure [13]. There are only three publications about the recurrent massive FMH in the subsequent pregnancy [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Fetomaternal hemorrhage complicated pregnancy

Stefanović

2016

Current Opinion in Obstetrics &Amp; Gynecology

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Section: Introductionmentioning

confidence: 99%

“…Disruption of the placenta during prenatal development, such as focal haemorrhage and subsequent inflammation, could also theoretically inhibit spiral arteriolar widening, contributing to reduced placental hypoperfusion and initiating a cascade of additional effects that include oxidative stress and endothelial cell dysfunction. [11][12][13] The umbilical cord insertion site is determined before placental growth. Abnormal placental shape and velamentous cord insertions frequently develop when the site of umbilical placental insertion in the uterus is low, because the early placenta develops with advancing gestation to ensure a better blood supply to the more richly vascularised area such as the uterine body.…”

Section: Introductionmentioning

confidence: 99%

Location of the placenta or the umbilical cord insertion site in the lowest uterine segment is associated with low maternal blood pressure

Hasegawa

Sekizawa

Farina

et al. 2011

BJOG

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Objective To evaluate whether placental abnormalities and umbilical cord insertion site affect the occurrence of pre-eclampsia and maternal blood pressure.Design Case-control study.Setting Showa University Hospital, Tokyo, Japan.Population A total of 5722 consecutive women who delivered singleton infants were included in the study.Methods The associations of placental abnormalities, the location of the placenta, the location of the cord insertion site, and maternal background with the occurrence of pre-eclampsia and maternal blood pressure at the term of pregnancy were analysed.Main outcome measure Pre-eclampsia and maternal blood pressure at the term of pregnancy.Results Pre-eclampsia was observed in 236 women (4.1%). Preeclampsia was frequently observed in women with placental form abnormalities (odds ratio 3.0) and infarction of the placenta (odds ratio 5.3). Pre-eclampsia was observed in 0 and 4.1% of women with and without placenta praevia, respectively (P = 0.004), and in 0 and 2.5% of women with and without low cord insertion during the first trimester, respectively (P = 0.018). After adjustment for confounding variables, the multivariate regression analyses revealed reductions of 8.4 and 5.0 mmHg in systolic and diastolic blood pressure, respectively, in women with placenta praevia compared with women without placenta praevia, and reductions of 4.3 and 3.1 mmHg in systolic and diastolic blood pressure, respectively, in women with low cord insertion during the first trimester compared with women without low cord insertion.Conclusion Not only placenta praevia but also low cord insertion are associated with low frequencies of pre-eclampsia and low maternal blood pressure.

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The association between preeclampsia and placental disruption induced by chorionic villous sampling

Abstract: The elevation of MSAFP and PAPP-A observed with CVS is associated with increased risk of subsequent PE. The ability of such increases to predict PE appears to be modest.

Cited by 13 publications

References 11 publications

Evaluation of passage of fetal erythrocytes into maternal circulation after invasive obstetric procedures

Evaluation of passage of fetal erythrocytes into maternal circulation after invasive obstetric procedures

Fetomaternal hemorrhage complicated pregnancy

Location of the placenta or the umbilical cord insertion site in the lowest uterine segment is associated with low maternal blood pressure

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