The association between pregnancy and COVID-19: A systematic review and meta-analysis

Wang, Hao; Li, Ning; Sun, Chenyu; Guo, Xianwei; Su, Wei; Song, Qiuxia; Liang, Qiwei; Liang, Mingming; Lowe, Scott; Bentley, Rachel; Sun, Yehuan

doi:10.1016/j.ajem.2022.03.060

Cited by 50 publications

(46 citation statements)

References 52 publications

(73 reference statements)

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“…These findings should be considered by both clinicians and pregnant women and could help to overcome vaccine hesitancy. Reducing the number of infections or hospitalisations is an important goal that would limit the risk of pregnancy and perinatal complications associated with symptomatic or severe COVID‐19, 3 , 4 , 5 , 44 , 45 prevent hospital‐related adverse events, 46 , 47 , 48 and reduce the economic burden on healthcare facilities.…”

Section: Discussionmentioning

confidence: 99%

“… 1 SARS‐CoV‐2 infection during pregnancy is associated with severe illness, with an increased risk of intensive care unit (ICU) admission, maternal death and adverse pregnancy outcomes. 2 , 3 , 4 , 5 COVID‐19 affects pregnancy in part because the immune system is directed towards fetal tolerance. 6 In addition, SARS‐CoV‐2 is targeted to the respiratory and cardiovascular systems, which are physiologically stressed during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness and safety of COVID‐19 vaccine in pregnant women: A systematic review with meta‐analysis

Tormen

Taliento

Salvioli

et al. 2022

BJOG

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Background There are limited data regarding COVID‐19 vaccination during pregnancy. Objectives To evaluate the effects of COVID‐19 vaccination received during pregnancy on SARS‐CoV‐2 infection, COVID‐19‐related hospitalisation, COVID‐19‐related intensive care unit (ICU) admission and maternal–fetal complications. Search strategy MEDLINE, CINHAL, Embase, Scopus and CENTRAL databases, as well as ClinicalTrials.gov , reference lists, related articles and grey literature sources. Selection criteria Randomised controlled trials, non‐randomised studies of interventions, pregnant women, COVID‐19 vaccination during pregnancy. Data collection and analysis Study selection, risk‐of‐bias assessment, data extraction and assessment of the certainty of evidence using the GRADE method were performed independently by two authors. Meta‐analyses were performed using Cochrane RevMan 5.4. PROSPERO registration number: CRD42022308849. Main results We included 14 observational studies (362 353 women). The administration of a COVID‐19 vaccine during pregnancy resulted in a statistically significant reduction in SARS‐CoV‐2 infection (OR 0.46, 95% CI 0.28–0.76) and COVID‐19‐related hospitalisation (OR 0.41, 95% CI 0.33–0.51). The effect appeared to be greater in fully vaccinated women, for both infection (OR 0.31, 95% CI 0.16–0.59) and hospitalisation (OR 0.15, 95% CI 0.10–0.21). However, the certainty of evidence was very low. The difference in COVID‐19‐related ICU admission between vaccinated and unvaccinated individuals did not reach statistical significance (OR 0.58, 95% CI 0.13–2.58). Finally, there were no statistically significant differences in any of the maternal–fetal complications considered in the included studies. Conclusions COVID‐19 vaccination administered during pregnancy seems to reduce SARS‐CoV‐2 infection and COVID‐19‐related hospitalisation, with no significant effects on maternal–fetal complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness and safety of COVID‐19 vaccine in pregnant women: A systematic review with meta‐analysis

Tormen

Taliento

Salvioli

et al. 2022

BJOG

View full text Add to dashboard Cite

show abstract

“…Las gestantes con COVID-19, tienen más probabilidades de desarrollar una enfermedad grave que las mujeres no gestantes, con una mayor tasa de ingreso a la unidad de cuidados intensivos (3).…”

Section: Afectación Materno-fetalunclassified

“…Pese a ser una enfermedad de aparición relativamente reciente, se genera información científica a un ritmo acelerado de datos sobre la presentación clínica durante el embarazo, los resultados perinatales y la atención obstétrica por la infección por COVID-19, con asociación a mayor riesgo de ingreso a unidades de cuidados intensivos y ventilación mecánica en comparación con la mujer no gestante, aunque permanece la incertidumbre sobre el impacto a nivel fetal (3). El SARS-CoV-2 es un virus de ARN, grande, esférico y cubierto con un genoma de aproximadamente 30 kilobase (kb) de longitud.…”

Section: Introductionunclassified

COVID-19 y placenta: afectación histopatológica y materno fetal

Campo

Lozada²

2022

Gac Méd Caracas

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La infección por COVID-19 es de reciente aparición, por lo que son escasos los datos sobre la presentación clínica durante el embarazo y los resultados perinatales. Los tipos de células de la placenta que expresan ECA2 son el sinciciotrofoblasto y el citotrofoblasto de las vellosidades coriónicas, las células del estroma decidual, las células perivasculares deciduales y las células del músculo liso vascular y endotelial.

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“…We read with interest a recent article entitled “ The association between pregnancy and COVID-19: A systematic review and meta-analysis ” by Wang et al in the American Journal of Emergency Medicine , and the study synthesized eight observational studies to reveal the association of pregnancy and the risk of mortality, intensive care unit (ICU) admission, as well as ventilation uses. The synthesis has clearly demonstrated that pregnancy was associated with significantly higher risk of ICU admission (risk ratio [RR], 2.23; 95% confidence interval [CI]: 1.58 to 3.16) and ventilation (RR, 2.13; 95% CI: 1.06 to 4.28), but not with the risk of mortality [ 1 ]. In addition to the terminal outcomes, the article also reported symptoms of COVID-19 between pregnant and non-pregnant women, and we recognize that these information are also valuable and meaningful to clinical practice.…”

mentioning

confidence: 99%

Associations between pregnancy and symptoms of COVID-19 are worth further analysis

Sun

Woo²,

Kang³

2022

The American Journal of Emergency Medicine

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The association between pregnancy and COVID-19: A systematic review and meta-analysis

Cited by 50 publications

References 52 publications

Effectiveness and safety of COVID‐19 vaccine in pregnant women: A systematic review with meta‐analysis

Effectiveness and safety of COVID‐19 vaccine in pregnant women: A systematic review with meta‐analysis

COVID-19 y placenta: afectación histopatológica y materno fetal

Associations between pregnancy and symptoms of COVID-19 are worth further analysis

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