The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis

Song, Junlong; Chen, Chuang; Sun, Shibin

doi:10.1007/s10689-017-9969-x

Cited by 7 publications

(7 citation statements)

References 43 publications

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Section: Discussionmentioning

confidence: 99%

“…A family history of breast or ovarian cancer is a confirmed prognostic factor for breast cancer, and it has been described that patients with TNBC have a higher proportion of family members with these diagnoses [7,36]. However, few studies have addressed the importance of this factor in the prognosis of breast cancer [37,38]. Song et al [37] performed a meta-analysis in which they aimed to evaluate the influence of breast cancer history in a first-degree relative and the risk of OS and breast cancer-specific survival.…”

Section: Plos Onementioning

confidence: 99%

“…However, few studies have addressed the importance of this factor in the prognosis of breast cancer [37,38]. Song et al [37] performed a meta-analysis in which they aimed to evaluate the influence of breast cancer history in a first-degree relative and the risk of OS and breast cancer-specific survival. They identified that a positive family history is a protective factor for OS.…”

Section: Plos Onementioning

confidence: 99%

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Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience

et al. 2020

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Background Epidemiological studies commonly identify the clinical characteristics and survival outcomes of patients with breast cancer at five years. Our study aims to describe the sociodemographic, clinicopathological characteristics and determine the long-term event-free survival (EFS) and overall survival (OS) of a Peruvian population with triple-negative breast cancer. Methods We reviewed the medical records of new cases treated at a single institution in the period 2000-2014. The survival analysis included patients with stages I-IV. Survival estimates at 10 years were calculated with the Kaplan-Meier method and compared with the Log-rank test. We further used multivariate Cox regression analysis to calculate prognostic factors of recurrence and mortality. Results Among the 2007 patients included, the median age at diagnosis was 49 years (19-95 years). Most patients presented histologic grade III (68.7%), tumor stage II (34.2%), and III (51.0%) at diagnosis. Local and distant relapse was present in 31.9 and 51.4% of the patients, respectively. The most frequent sites of metastasis were the lungs (14.5%), followed by bone (9.7%), brain (9.6%), and liver (7.9%). The median follow-up was 153 months. At 3, 5, and 10 years, the EFS of the population was 55%, 49%, and 41%, respectively, while the OS was 64%, 56%, and 47%, respectively. Moreover, an N3 lymph node status was the most important prognostic factor for both disease relapse (HR: 2.54, 95% CI:

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Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

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Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience

et al. 2020

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“…One study estimated that the 10-year OS rate was 73% in patients with sporadic BC, 75% in intermediate-risk patients, and 82% in high-risk patients (log-rank p < 0.0001) [40]. Correspondingly, a meta-analysis reported a better OS in BC patients with a first-degree family history of BC/OC (OR 0.89; 95% CI 0.83–0.95) [51].…”

Section: Discussionmentioning

confidence: 99%

Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

et al. 2020

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Purpose: In breast cancer, a pathological complete response (pCR) has been described as generally resulting in a favorable prognosis. However, there are subgroups, such as patients with a mutation in BRCA1 or BRCA2,in which the effect of pCR on the prognosis is suspected to be weaker. Patients with a family history of breast and/or ovarian cancer may therefore react differently in relation to pCR and prognosis, and this is investigated in this study. Patients and Methods: Breast cancer patients were identified from a clinical breast cancer registry. The study subjects had been treated with neoadjuvant chemotherapy from 2001 to 2018 and their pathological and clinical information as well as medical family history were available. They were considered to have a positive family history if they had at least 1 first-degree relative with breast and/or ovarian cancer. Multivariate logistic regression analyses were performed to study the association between family history, pCR (ypT0; ypN0), and disease-free survival (DFS). Results: Of 1,480 patients, 228 (15.4%) had a positive family history. The pCR rates were 24.9% in all patients, and 24.4% and 27.6% in those without/with a family history, respectively. Family history was not associated with a higher pCR rate (adjusted odds ratio [OR] 1.23; 95% confidence interval [CI] 0.85–1.76; p = 0.27) or a different disease-free survival (DFS; adjusted hazard ratio [HR] 1.15; 95% CI 0.88–1.52; p = 0.30). pCR did not affect the prognosis differently in relation to family history. Conclusions: In this retrospective analysis, family history was not associated with pCR and DFS. pCR improved survival, independently of family history.

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“…Several studies reported better survival for women with a positive family history of breast cancer as compared to those without [2,3], whereas others reported no difference or worse survival [4][5][6]. A recent meta-analysis performed to clarify this issue demonstrated that having a first-degree relative with breast and/ or ovarian cancer was associated with better overall survival and breast cancer-specific survival [7]. No clear conclusion could be drawn from subgroup analyses due to the limited number of studies available.…”

Section: Introductionmentioning

confidence: 99%

Concordance of tumour characteristics and survival clustering among pairs of first-degree relatives with breast cancer

et al. 2020

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BACKGROUND: Family history is a known risk factor for breast cancer, but its prognostic value and the prognostic value of tumour characteristics in relation to family history has not been clearly established. In addition, studies of intra-familial tumour characteristics and prognosis in population-based settings are very rare. Two previous studies have suggested that breast cancer prognosis clusters within families. However, both studies lack information on HER2 expression status, which is a strong prognostic factor and could contribute to the observed results.METHODS: We conducted a population-based study on 145 mother-daughter and sister-sister affected pairs using data extracted from the Geneva Cancer Registry. Histopathological characteristics were determined in archived tumour blocks by immunochemistry techniques. Breast cancer survival among family members was studied according to patient and tumour characteristics.RESULTS: No significant intra-familial agreement of pathological characteristic features was observed. We found that relatives of breast cancer patients experienced a much higher risk of breast cancer death compared to the general population. However, we did not find significant concordance in good and poor breast cancer-specific survival between pairs. The small number of family pairs and deaths from breast cancer may partly explain our results. CONCLUSIONS: Large-scale studies with accurate data on strong prognosticators are still needed to confirm the possibility of familial inheritance of breast cancer prognosis.

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The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis

Cited by 7 publications

References 43 publications

Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience

Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience

Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

Concordance of tumour characteristics and survival clustering among pairs of first-degree relatives with breast cancer

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