The Association Between Prolonged Fatigue and Cardiovascular Disease in World War II Veteran Twins

Fitzpatrick, Annette L.; Reed, Terry; Goldberg, Jack; Buchwald, Dedra

doi:10.1375/1369052042663913

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…By inference, similar processes may explain the onset of post-stroke fatigue. Research also showed a significant association between fatigue and cardiovascular disease (CVD), another inflammatory and O&NS disease [194]. There is also an increased incidence of chronic fatigue in hemodialysis patients ('hemodialysis fatigue') [195].…”

Section: Neuroimmune Pathways In Sickness Behavior and Me/cfsmentioning

confidence: 99%

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

Morris¹,

Anderson²,

Gałecki

et al. 2013

BMC Med

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It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.

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Section: Neuroimmune Pathways In Sickness Behavior and Me/cfsmentioning

confidence: 99%

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

Morris¹,

Anderson²,

Gałecki

et al. 2013

BMC Med

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“…Patients have described the impact of post-MI fatigue on their ability to carry out even daily activities as “paralyzing,” “restricting,” and “incomprehensible” (Alsen, Brink, & Persson, 2008). However, in many studies examining fatigue in heart disease, researchers have either used unidimensional measures of fatigue (Brink & Grankvist, 2006; Fitzpatrick, Reed, Goldberg, & Buchwald, 2004) or have not clearly reported how the multi-dimensions of fatigue affect outcomes such as PA.…”

mentioning

confidence: 99%

Fatigue and Physical Activity After Myocardial Infarction

Crane

Abel

McCoy

2014

Biological Research For Nursing

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Background Fatigue is prevalent after myocardial infarction (MI) and is a barrier to physical activity (PA). Because PA is an important health behavior in preventing or delaying recurrent MIs, examining the influence of biophysical markers and fatigue on PA is important as a prerequisite to developing effective interventions. Objective This study compared PA in 34 men and 38 women, aged 65 and older, 6–8 months post MI, and examined the influence of biophysiological measures and fatigue on PA in this sample. Methods Using a cross-sectional descriptive correlational design, adults completed a demographic form that included documentation of blood pressure, heart rate, height and weight; the Revised Piper Fatigue Scale (RPFS), and the Community Healthy Activities Model Program for Seniors Physical Activity Questionnaire for Older Adults, and blood collection for measurement of hemoglobin (Hgb), interleukin-6, and B-natriuretic peptide. Results There were no differences in frequency of PA between older men and older women; however, men reported a higher intensity of PA (p = .011). When controlling for sex, age, and biophysiological measures, the RPFS significantly explained 16% of the variance in the frequency of PA (p = .03), with no individual subscale serving as a significant predictor. The RPFS behavior/severity subscale explained 31% of the variance in energy expended on all PA (p < .001) and 40% of the variance in energy expended on moderate-intensity PA (p < .001). Conclusion The older adults participating in this study did not participate in the recommended levels of PA, and fatigue significantly influenced PA post MI.

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“…Few studies investigated the association between fatigue and cardiovascular health in the general population. An early cohort study focused on World War II veteran twins indicated that prolonged fatigue was strongly associated with both risk of MI and CHD after adjustment for traditional risk factors ( 22 ). A large-scale prospective cohort study further revealed that participants with higher fatigue were at greater risk of cardiovascular disease-related death ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis

Qi,

Wang,

Qiu

et al. 2023

Front. Psychiatry

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BackgroundObservational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear.MethodWe conducted a bidirectional Mendelian randomization (MR) study using publicly available genome-wide association studies (GWAS) data. The inverse-variance weighted (IVW) method was used as the primary analysis. We performed three complementary methods, including weighted median, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) to evaluate the sensitivity and horizontal pleiotropy of the results.ResultSelf-reported fatigue had a causal effect on coronary artery atherosclerosis (CAA) (OR 1.047, 95%CI 1.033–1.062), myocardial infarction (MI) (OR 1.027 95%CI 1.014–1.039) and coronary heart disease (CHD) (OR 1.037, 95%CI 1.021–1.053). We did not find a significant reverse causality between self-reported fatigue and CAD. Given the heterogeneity revealed by MR-Egger regression, we employed the IVW random effect model. For the examination of fatigue on CHD and the reverse analysis of CAA, and MI on fatigue, the MR-PRESSO test found horizontal pleiotropy. No significant outliers were found.ConclusionThe MR analysis reveals a causal relationship between self-reported fatigue and CAD. The results should be interpreted with caution due to horizontal pleiotropy.

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The Association Between Prolonged Fatigue and Cardiovascular Disease in World War II Veteran Twins

Cited by 11 publications

References 37 publications

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

Fatigue and Physical Activity After Myocardial Infarction

Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis

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