The association between pulmonary function and depression in middle-aged and elderly people in China: The role of cognitive ability and sleep time

Bao, Min; Chao, Jianqian; Cai, Ruixue; Zhang, Na; Chen, Hongling; Sheng, Mingxin

doi:10.1016/j.jad.2021.12.017

Cited by 4 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Favourable physical performance in older adults could potentially lead to increased outdoor activity time and enhanced social opportunities, thereby benefiting their mental well-being and contributing to the prevention and management of depression. [26][27][28][29][30] This study has several strengths. First, it utilized a cohort study design, which enhances the validity of causal associations.…”

Section: Discussionmentioning

confidence: 99%

“…Strong SPPB scores indicate better physical condition, an important factor in the willingness of the elderly to perform daily physical activities 25 . Favourable physical performance in older adults could potentially lead to increased outdoor activity time and enhanced social opportunities, thereby benefiting their mental well‐being and contributing to the prevention and management of depression 26–30 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association between the Short Physical Performance Battery and longitudinal trajectories of depressive symptoms among Chinese older adults

Bao,

Chao,

Zhang

et al. 2023

Psychogeriatrics

Self Cite

View full text Add to dashboard Cite

BackgroundIn this study, the long‐term trajectories of depressive symptoms in a 7‐year prospective survey cohort of Chinese older adults were explored. Additionally, the study examined whether there was an independent association between scores on the Short Physical Performance Battery (SPPB) and the different trajectories of depressive symptoms.MethodsA total of 2177 elderly individuals had their depressive symptoms assessed based on the Center for Epidemiological Studies‐Depression (CES‐D) scale in the years 2011, 2013, 2015, and 2018. In addition, their demographic characteristics, chronic diseases, and lifestyle factors were also assessed. The trajectories of depressive symptoms were analysed using the group‐based trajectories analysis model. Furthermore, the relationship between the objectively measured SPPB scores and the long‐term trajectory of depressive symptoms was explored using multinomial logistic regression.ResultsThe group‐based trajectory analysis model categorized the trajectories of depressive symptoms across four waves into four groups: persistent low depressive symptoms, increasing depressive symptoms, decreased depressive symptoms, and persistent high depressive symptoms. After controlling for confounding factors, it was observed that a higher baseline SPPB score was associated with an increased likelihood of persistent high depressive symptoms, OR (95% CI) = 0.724 (0.644, 0.814), for the persistent high depressive symptoms versus the persistent low depressive symptoms.ConclusionsLow levels of SPPB score are associated with persistent high depressive symptoms in older adults. Conversely, improving physical performance as measured by the SPPB can help reduce the risk of major depressive disorder and persistent depressive disorder in the elderly.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The association between the Short Physical Performance Battery and longitudinal trajectories of depressive symptoms among Chinese older adults

Bao,

Chao,

Zhang

et al. 2023

Psychogeriatrics

Self Cite

View full text Add to dashboard Cite

show abstract

Mediation analysis of cognitive function in the relationship between pulmonary function and depression among middle‐aged and older adults

Yang,

Zhu,

Dai

et al. 2024

Geriatrics Gerontology Int

View full text Add to dashboard Cite

AimThis study aims to explore the association between declining lung function and depression in middle‐aged and older adults, with a special focus on the mediating role of cognitive function.MethodsThis study utilizes self‐reported and physical examination data from 5345 individuals participating in the 2015 cycle of the China Health and Retirement Longitudinal Study (CHARLS) to explore the role of cognitive function changes in mediating the effects of diminished lung function on depression among middle‐aged and older adults.ResultsMultivariate linear regression analysis revealed a positive correlation between pulmonary and cognitive functions (β = 0.003, 95% CI: 0.002∼0.003, P < 0.01) and a negative correlation between cognitive function and depression (β = −0.279, 95% CI: −0.330–0.228, P < 0.01). Cognitive function plays a mediating role in linking pulmonary function with depression, exhibiting a mediation effect of −0.0007 and a total effect of −0.0046, wherein the mediation effect contributes to 15.22% of the total effect. For females, the mediating effect of cognitive function was stronger (β = −0.0013, 95% CI: −0.0018∼–0.0008, P < 0.01) than it was for males (β = −0.0006, 95% CI: −0.0009∼–0.0003, P < 0.01).ConclusionsThe study underscores the importance of monitoring lung and cognitive functions as interconnected factors contributing to the mental health of middle‐aged and older adults. It suggests that interventions aimed at improving pulmonary health and cognitive function may help mitigate depressive symptoms among middle‐aged and older adults. Further research is warranted to validate these findings across diverse cultural and demographic settings. Geriatr Gerontol Int 2024; ••: ••–••.

show abstract

Genetic overlap between impaired lung function and cardiovascular diseases revealed by a large-scale genome-wide cross-trait analysis

Wu,

Zhou,

Lyu

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Increasing evidence have highlighted the phenotypic association between impaired lung function and cardiovascular diseases (CVD), but underlying shared genetic basis contributing to this association remain largely unexplored. Methods Utilizing summary data from the large-scale genome-wide association studies, our investigation delved into several aspects: the global and local genetic correlations, pleiotropic loci, and causal association between lung function and three prevalent CVD, namely coronary artery disease (CAD), heart failure (HF), and stroke. Results Our findings revealed significantly negative genetic correlations between lung function and CAD (rg = -0.20 to -0.17), HF (rg = -0.18 to -0.17), and stroke (rg = -0.17 to -0.16). After separating the whole genome into 2,353 independent regions, we determined 13, 4, and 3 significant regions for CAD, HF, and stroke with lung function, respectively. Furthermore, the global and local shared genetic basis were confirmed by the identification of multiple pleiotropic loci and multiple shared gene–tissue pairs. The pleiotropic loci were largely enriched in brain-related tissues, while shared gene-tissue pairs exhibited significant enrichment across nervous, cardiovascular, digestive, endocrine/exocrine, and respiratory systems. Mendelian randomization analysis demonstrated a significant causal association of genetically predicted lung function with CAD [OR (odds ratio) = 0.69 to 0.72] and stroke (OR = 0.81 to 0.90) but not with HF. No evidence of reverse causality was found. Conclusions These findings comprehensively uncover a shared genetic architecture as well as a causal association between impaired lung function and CVD, emphasizing the opportunity to enhance the quality of existing intervention strategies.

show abstract

The association between pulmonary function and depression in middle-aged and elderly people in China: The role of cognitive ability and sleep time

Cited by 4 publications

References 36 publications

The association between the Short Physical Performance Battery and longitudinal trajectories of depressive symptoms among Chinese older adults

The association between the Short Physical Performance Battery and longitudinal trajectories of depressive symptoms among Chinese older adults

Mediation analysis of cognitive function in the relationship between pulmonary function and depression among middle‐aged and older adults

Genetic overlap between impaired lung function and cardiovascular diseases revealed by a large-scale genome-wide cross-trait analysis

Contact Info

Product

Resources

About