The association between RDW and survival of patients with squamous cell carcinoma of the tongue. Simple, cheap and convenient?

Miszczyk, Marcin; Jabłońska, Iwona; Magrowski, Łukasz; Masri, Oliwia; Rajwa, Paweł

doi:10.1016/j.rpor.2020.03.026

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…Beyond the usual clinical applications, both RDW, NLR, and PLR have been a subject of investigation in oncology and proven to be useful as prognostic factors in many cancers. For example, some studies have proved the connection of the RDW with prognosis in head and neck cancer [ 12 ], digestive tract including esophagus [ 8 ], colon and rectum [ 9 ], or gastric cancer [ 10 ]. The elevated value of RDW was associated with poor survival in breast cancer patients [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Elevated RDW is associated with anemia, chronic inflammation, and malnutrition [ 5 ] which are frequently associated with advanced cancer [ 6 ]. Besides, chronic inflammation may further accelerate or lead to carcinogenesis and neovascularization due to inflammatory cytokines [ 7 ], and elevated RDW has proven to be a negative prognostic factor in many malignant tumors [ 8 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

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The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer

Staniewska

Tomasik

Tarnawski

et al. 2021

Rep Pract Oncol Radiother.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer

Staniewska

Tomasik

Tarnawski

et al. 2021

Rep Pract Oncol Radiother.

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“…Multiple studies indicate that blood morphology indices, such as red blood cell distribution width (RDW) [6][7][8][9][10][11][12][13], neutrophil-to-lymphocyte ratio (NLR) [14][15][16][17][18][19], and platelet-to--lymphocyte ratio (PLR) [6,[19][20][21], may be prognostic factors in cancer patients. Such indices could be particularly useful for clinicians given that the majority are based on routinely performed laboratory tests.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of RDW, NLR and PLR in sequential radio-chemotherapy for advanced lung cancer

Jabłońska

Miszczyk

Goławski

et al. 2022

Nowotwory. Journal of Oncology

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Introduction.Inflammation plays an important role in carcinogenesis, therefore morphology-based inflammatory indices could be prognostic factors in lung cancer patients. This study aimed to analyze if red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are associated with patients' prognosis in non-small cell lung cancer (NSCLC) patients. Material and methods. The study population included 110 patients treated with definitive sequential radio-chemotherapy for stage IIIA-IIIB NSCLC. The data were retrospectively analyzed using the receiver operating characteristic (ROC) method, Kaplan-Meier estimator, log-rank testing, and Cox proportional hazards regression model. Results.The ROC analysis has shown that the optimal cut-off values were 14% for RDW, 2.1 for NLR, and 120 for PLR, with area under the curve (AUC) of 0.606, 0.509, and 0.564 respectively. The overall survival was significantly higher in patients with RDW ≤ 14% with a median survival of 31.2 months compared to 20.2 months for patients with RDW > 14%. RDW was an independent prognostic factor in multivariate analysis. Conclusions. RDW can provide additional information in assessing patients' prognosis, but it is necessary to consider its modest sensitivity and specificity. NLR and PLR were not found to be independent prognostic factors.

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“…Red blood cell distribution width (RDW) is a parameter that reproduces the volume heterogeneity of RBCs, and it can be obtained from the standard deviation (SD) of erythrocyte volumes for the mean corpuscular volume (MCV) 16 . High RDW values reveal greater size variations of red blood cells, which were reported to be associated with multiple interconnected factors, such as chronic inflammation, prolonged bleeding, or oxidative stress 17 . Although a variation of RDW was reported to be related to various malignancies such as prostate cancer, 18 lung cancer, 19 and chronic lymphocytic leukemia, 20 its prognostic role still remains controversial.…”

Section: Introductionmentioning

confidence: 99%

“…16 High RDW values reveal greater size variations of red blood cells, which were reported to be associated with multiple interconnected factors, such as chronic inflammation, prolonged bleeding, or oxidative stress. 17 Although a variation of RDW was reported to be related to various malignancies such as prostate cancer, 18 lung cancer, 19 and chronic lymphocytic leukemia, 20 its prognostic role still remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma

Raimondo

Caposiena

Spallone³

et al. 2021

Int J Dermatology

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Background The neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) at diagnosis have been shown to correlate with advanced disease and to be prognostic factors in many tumors. However, their role as a prognostic factor for cutaneous squamous cell carcinoma (cSCC) has not yet been studied.Objective Therefore, the aim of our study was to evaluate the correlation of NLR and RDW with stages of disease in patients with cSCC in order to define whether or not higher values of these two markers correlate with a more aggressive disease.Methods We retrospectively analyzed the NLR and RDW in a total of 51 newly diagnosed cSCC patients. NLR and RDW were calculated using data obtained from the complete blood count (CBC). ResultsMedian NLR among patients with the non-advanced disease (in situ and stage I) was 2.2, whereas median NLR for patients with advanced disease was 4.87. Median RDW among patients with early stage disease was 13.7%, while median RDW in patients with advanced disease was 15.81%. Statistical analysis showed positive associations of advanced cSCC stages with NLR or RDW higher than 3.07 or 14.5%, respectively.Conclusions Therefore, our analysis demonstrated how both NLR and RDW represent cheap and easily available factors that could be used as markers for advanced cSCC.They could help to identify patients with advanced stages disease that requires a strict follow-up.

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The association between RDW and survival of patients with squamous cell carcinoma of the tongue. Simple, cheap and convenient?

Cited by 6 publications

References 30 publications

The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer

The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer

The prognostic value of RDW, NLR and PLR in sequential radio-chemotherapy for advanced lung cancer

Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma

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