The Association Between Reactive Oxygen Metabolites and Metabolic Syndrome in Asymptomatic Japanese Men

Kotani, Kazuhiko; Taniguchi, Nobuyuki

doi:10.4021/jocmr668w

Cited by 9 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A mild correlation between weight changes and plasma oxidative parameters alteration was observed; even in the canine species, mechanisms similar to those already documented in humans, in which the alteration between production and removal of radical species occurs in obese subjects, but also in "pre-obesity" condition and in asymptomatic subjects, can be assumed [1,4,16,17]. A positive correlation between number of lymphocytes and BAP or α-tocopherol is fully consistent with the importance of antioxidants on immunological functions.…”

Section: Discussionsupporting

confidence: 83%

“…Alone or in combination with primary etiological factors, free radicals are involved in a pathogenesis of many inflammatory, degenerative and neoplastic diseases [2,3]. Recently, the prevalence of obesity has been related to a decrease of the plasma antioxidants [4][5][6], the accumulation of fat has been related to the increase of oxidative stress markers [1,4,6], the oxi-dative stress has been related to high body mass index (BMI) in human [7] and, finally, obesity has been related to chronic inflammatory status [8]. When caloric intake exceeds energy expenditure, the substrate-induced increase in Krebs cycle activity generates an excess of ROS [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Body Condition and Oxidative Status in Dogs

Pasquini¹,

Roberti²,

Meucci³

et al. 2013

FNS

View full text Add to dashboard Cite

Oxidative Stress (OS) is considered an underlying mechanism by which dysfunctional metabolism occurs in obese subjects but there are still very few studies in canine species. The purpose of this study was to evaluate simultaneously the effects of diet on body weight, oxidative and inflammatory status in a group of 12 adult dogs. The dogs were fed a maintenance diet, integrated with natural antioxidants, for a period of 6 months. At the beginning and the end of the trial, Body Condition Score (BCS) was evaluated and haematological (CBCs, Complete Blood Counts), oxidative parameters (d-ROMs, derivatives of Reactive Oxygen Metabolites; BAP, Biological Antioxidant Potential; Retinol; α-tocopherol) and inflammatory parameters (Fibrinogen; CRP, C Reactive Protein) were performed. Significant differences (p < 0.05) emerged about BCS, hematocrit (HCT), number of platelets (PLT), d-ROMs, BAP and retinol while no differences were for α-tocopherol, fibrinogen and CRP between the two periods of different diet. In this study, dogs showed an oxidative imbalance documented by the increase in d-ROMs and the reduction of BAP and retinol. Inflammatory parameters don’t change in relation to body weight like an alteration of the oxidative status could precede the onset of inflammation. The role of oxidative stress and of integration with antioxidants should be taken into special consideration in the dietary treatment in overweight dogs

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Association between Body Condition and Oxidative Status in Dogs

Pasquini¹,

Roberti²,

Meucci³

et al. 2013

FNS

View full text Add to dashboard Cite

show abstract

“…An association between ROS and metabolic syndrome has been demonstrated in asymptomatic Japanese men [166]. Diet-induced obesity increases the levels of total and individual ROS in the brain and highlights a direct relationship between the amount of adiposity and the level of oxidative stress within the brain [167], suggesting that obesity increases cerebro-cortical ROS and impairs brain function.…”

Section: Introductionmentioning

confidence: 99%

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

Lương

Nguyễn

2013

Nutr J

View full text Add to dashboard Cite

The prevalence rates of overweight and obesity are considered an important public issue in the United States, and both of these conditions are increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Vitamin D deficiency is highly prevalent in patients with obesity, and many studies have demonstrated the significant effect of calcitriol on adipocytes. Genetic studies have provided an opportunity to determine which proteins link vitamin D to obesity pathology, including the vitamin D receptor, toll-like receptors, the renin-angiotensin system, apolipoprotein E, vascular endothelial growth factor, and poly (ADP-ribose) polymerase-1. Vitamin D also exerts its effect on obesity through cell-signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the reduced form of nicotinamide adenine dinucleotide phosphate, prostaglandins, reactive oxygen species, and nitric oxide synthase.In conclusion, vitamin D may have a role in obesity. The best form of vitamin D for use in the obese individuals is calcitriol because it is the active form of the vitamin D3 metabolite, its receptors are present in adipocytes, and modulates inflammatory cytokine expression.

show abstract

“…The increase in reactive oxygen species production from adipose tissue also leads to increased oxidative stress in the blood, thereby affecting other organs, including the liver, skeletal muscle, and aorta. Furthermore, increased serum d-ROM levels have been linked to human metabolic disorders, including hyperlipidemia (Yamaoka-Tojo et al, 2009;Kotani and Taniguchi, 2011). It is therefore believed that an alleviation of oxidative stress in adipose tissue may cause concurrent decreases in serum reactive oxygen species concentrations and mediate improvements in obesity-associated metabolic disorders.…”

mentioning

confidence: 99%

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Toshimitsu

Mochizuki

Ikegami

et al. 2016

Journal of Dairy Science

View full text Add to dashboard Cite

In this study, we identified a strain of lactic acid bacteria (LAB) that induces high levels of IL-10 production by immune cells, and evaluated the ability of the strain to suppress chronic inflammation and ameliorate metabolic disorders in in vitro and in vivo models. Among a collection of LAB strains, Lactobacillus plantarum strain OLL2712 (OLL2712) induced the highest levels of IL-10 production in mouse-derived dendritic cells and peritoneal macrophages. The anti-inflammatory effects of this strain were evaluated using a co-culture system comprising RAW 264.7 and 3T3-L1 cells. We also administered heat-killed OLL2712 to obese and type 2 diabetic KKAy mice for 3 wk to evaluate the in vivo effects of the strain. The OLL2712 significantly decreased the production of proinflammatory cytokines in vitro. Likewise, the administration of OLL2712 significantly suppressed proinflammatory cytokine levels in both the visceral adipose tissue and the serum of KKAy mice, and reduced serum triglyceride concentrations. The strain also alleviated oxidative stress and adrenaline levels in the serum of KKAy mice. On the other hand, Lactobacillus gasseri strain MEP222804 (a moderate IL-10 inducer) did not ameliorate the systemic inflammation and hyperlipidemia in KKAy mice. Our results suggest that treatment with strong IL-10-inducing LAB has the potential to ameliorate metabolic disorders by suppressing chronic inflammation in the host animal.

show abstract

The Association Between Reactive Oxygen Metabolites and Metabolic Syndrome in Asymptomatic Japanese Men

Cited by 9 publications

References 24 publications

Association between Body Condition and Oxidative Status in Dogs

Association between Body Condition and Oxidative Status in Dogs

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice

Contact Info

Product

Resources

About