The association between reduced kidney function and hearing loss: a cross-sectional study

Liu, Wenwen; Meng, Qinqin; Wang, Yafeng; Yang, Chao; Liu, Huan; Wang, Huaiyu; Su, Zaiming; Kong, Guilan; Zhao, Yaohui; Zhang, Luxia

doi:10.1186/s12882-020-01810-z

Cited by 23 publications

(24 citation statements)

References 44 publications

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“…This prevalence is somewhat lower than in previous reports, 29%–40%, 10 12 but much higher than that in the general population of over 5%. 5 In our study, the overall prevalence of SNHL was 12.1%, which was higher than the 1.2% reported in the Korean adolescents 27 (no data available for CHL). Therefore, we suggest that the possibility of HL should be considered in pediatric CKD patients, requiring surveillance and early intervention, if necessary.…”

Section: Discussioncontrasting

confidence: 71%

“…HL is more prevalent in patients with chronic kidney disease (CKD) than in the general population. 5 8 While the overall prevalence of HL with CKD is 40%–75% in adults and about 40% in children, 9 10 SNHL is more common than CHL in this population, 8 11 with the prevalence of SNHL in adult patients estimated to be 20%–87% and 29%–40% in children. 10 12 Several potential hypotheses have been proposed to explain the higher prevalence of HL in patients with CKD; one of them is that the kidney and the stria vascularis of the cochlea share physiologic, ultrastructural, and antigenic characteristics that could underlie the link between CKD and HL.…”

Section: Introductionmentioning

confidence: 95%

“… 2 3 Even unilateral HL may impair school performance and lead to educational failure and deleterious behavior outcomes. 4 Known to affect more than 5% of the general population, 5 HL can be grouped into sensorineural hearing loss (SNHL), conductive hearing loss (CHL), and mixed form. SNHL is caused by abnormalities in the inner ear, cochlea, or the auditory nerve, and CHL results from the middle or outer ear diseases, commonly acute otitis media or otitis media with effusion (OME).…”

Section: Introductionmentioning

confidence: 99%

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Renal Syndromic Hearing Loss is Common in Childhood-onset Chronic Kidney Disease

Kim

Lee

et al. 2020

J Korean Med Sci

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Background: Hearing loss (HL) in children may adversely affect their development. HL is more prevalent in patients with chronic kidney disease (CKD) than in the general population. This study evaluated the prevalence of HL and its underlying diseases in patients with childhood-onset in CKD. Methods: In this retrospective study of a tertiary referral center, childhood-onset CKD patients (stage 2-5, age at onset of renal symptom < 18 years) were recruited. We referred to the "renal" syndromic HL as cases with genetic or syndromic diseases, or extra-renal anomalies in addition to HL and CKD. Results: A total of 421 patients (male:female = 279:142) were reviewed according to the causes of CKD: congenital anomalies of the kidney and urinary tract (CAKUT; n = 184, 43.7%), glomerulopathies (GP; n = 105, 24.9%), cystic kidney diseases (CYST; n = 39, 9.3%), perinatal problems (PP; n = 29, 6.9%), and others (n = 64, 15.2%). HL was detected in 82 (19.5%) patients, including 51 (12.1%) patients with sensorineural hearing loss (SNHL), 30 (7.1%) with conductive hearing loss (CHL), and 1 patient with mixed HL. The prevalence of HL in each group was as follows: 16.8% in the CAKUT group, 28.6% in the GP group, 12.8% in the CYST group, 24.1% in the PP group, and 14.1% in the others group. HL was more common in higher CKD stages, especially CHL in end-stage renal disease. SNHL was more prevalent in CKD from GP. Of the 82 patients with HL, 50% had renal syndromic HL: 58.8% of SNHL and one-third of CHL were renal syndromic HL. Conclusion: One-fifth of the childhood-onset CKD had HL. Collectively, renal syndromic HL comprised half of the HL in this study. To improve the quality of life in patients with childhood-onset CKD, we suggest that HL should be considered, requiring surveillance, and if necessary, early intervention.

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Renal Syndromic Hearing Loss is Common in Childhood-onset Chronic Kidney Disease

Kim

Lee

et al. 2020

J Korean Med Sci

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“…Participants with CKD Stages 3b-5 had less social participation ( 23 ). Reduced kidney function was also independently associated with hearing loss, which may cause social isolation ( 24 ). The previous studies both revealed that CKD was associated with social isolation.…”

Section: Discussionmentioning

confidence: 99%

Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)

Zhou

Ning

et al. 2021

Front. Med.

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Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and elderly Chinese with normal kidney function.Methods: We analyzed data from 3,031 participants aged ≥ 45 years with baseline estimated glomerular filtration rates (eGFR) ≥ 60 ml/min/1.73 m2. All data were obtained from the 2011 and 2015 waves of the Chinese Longitudinal Study of Health and Retirement (CHARLS). eGFR was estimated based on a combination of serum creatinine and cystatin C. The primary outcome was rapid decline in renal function, as defined by an eGFR decrease of > 5 ml/min/1.73 m2 per year, while the secondary outcome was the development of CKD, as defined by an eGFR decrease to a level < 60 ml/min/1.73 m2.Results: During the follow-up of 4 years, 258 (8.5%) participants experienced a rapid decline in renal function, while 87 (2.9%) developed CKD. In the fully adjusted model, high social isolation was significantly related to an increased risk of experiencing a rapid decline in renal function (OR 1.805, 95% CI 1.310–2.487) and CKD onset (OR 1.842, 95% CI 1.084–3.129). Among the five components of social isolation, being unmarried, not participating in social activities, and living alone independently predicted declined renal function.Conclusions: Social isolation is significantly associated with the risk of rapid eGFR decline and CKD onset in middle-aged and older adults with normal kidney function in China.

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“…Recently, a study in adults confirmed that reduced kidney function is independently associated with hearing loss development. 71 However, aminoglycosides and glycopeptides are also known to be nephrotoxic, 72 , 73 possibly leading to reduced kidney function. The exact mechanisms that may influence systemic and cochlear electrolyte homeostasis in children are still unexplored and unclear, which urges the need for further in vitro and in vivo studies.…”

Section: Discussionmentioning

confidence: 99%

Aminoglycoside- and glycopeptide-induced ototoxicity in children: a systematic review

Diepstraten

Hoetink

Grotel

et al. 2021

JAC-Antimicrobial Resistance

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Background Ototoxicity has been reported after administration of aminoglycosides and glycopeptides. Objectives To identify available evidence for the occurrence and determinants of aminoglycoside- and glycopeptide-related ototoxicity in children. Materials and methods Systematic electronic literature searches that combined ototoxicity (hearing loss, tinnitus and/or vertigo) with intravenous aminoglycoside and/or glycopeptide administration in children were performed in PubMed, EMBASE and Cochrane Library databases. Studies with sample sizes of ≥50 children were included. The QUIPS tool and Cochrane criteria were used to assess the quality and risk of bias of included studies. Results Twenty-nine aminoglycoside-ototoxicity studies met the selection criteria (including 7 randomized controlled trials). Overall study quality was medium/low. The frequency of hearing loss within these studies ranged from 0%–57%, whereas the frequency of tinnitus and vertigo ranged between 0%–53% and 0%–79%, respectively. Two studies met the criteria on glycopeptide-induced ototoxicity and reported hearing loss frequencies of 54% and 55%. Hearing loss frequencies were higher in gentamicin-treated children compared to those treated with other aminoglycosides. In available studies aminoglycosides had most often been administered concomitantly with platinum agents, diuretics and other co-medication. Conclusions In children the reported occurrence of aminoglycoside/glycopeptide ototoxicity highly varies and seems to depend on the diagnosis, aminoglycoside subtype and use of co-administered medication. More research is needed to investigate the prevalence and determinants of aminoglycoside/glycopeptide ototoxicity. Our results indicate that age-dependent audiological examination may be considered for children frequently treated with aminoglycosides/glycopeptides especially if combined with other ototoxic medication.

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The association between reduced kidney function and hearing loss: a cross-sectional study

Cited by 23 publications

References 44 publications

Renal Syndromic Hearing Loss is Common in Childhood-onset Chronic Kidney Disease

Renal Syndromic Hearing Loss is Common in Childhood-onset Chronic Kidney Disease

Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)

Aminoglycoside- and glycopeptide-induced ototoxicity in children: a systematic review

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