The association between rotating night shift work and hypertension: A cross-sectional study among male workers

Khosravipour, Masoud; Mohammadi, Mostafa; Athar, Hossein Valadi; Jamebozorgi, Iraj; Khanlari, Payam; Gharagozlou, Faramarz

doi:10.1177/2047487320906921

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…(77). Significant associations between night shifts and hypertension have been reported by more recent studies on subjects with rotational shifts, short shift intervals, and consecutive night shifts (78)(79)(80).…”

Section: Insomniamentioning

confidence: 93%

Treating sleep disorders to improve blood pressure control and cardiovascular prevention: a dream come true?—a narrative review

Maiolino¹,

Bisogni²,

Silvani³

et al. 2020

J Thorac Dis

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Hypertension is one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide. Current evidence supports the treatment of high blood pressure (BP) values in order to obtain a substantial reduction of cardiovascular burden. Sleep plays an important role in maintaining nocturnal BP control and nocturnal hypertension which, in turn, can be affected by the presence of sleep disorders. Whilst respiratory disturbances have been extensively studied and their causal role in the development of nocturnal hypertension has been demonstrated in both cross sectional and prospective studies, less is known about the impact of other sleep disorders such as insomnia. In this review, we aim to describe the role of sleep disorders in the development of nocturnal and diurnal hypertension. Furthermore, we aim to discuss the potential impact of the treatment of such sleep disorders on BP values as an adjunct treatment for patients with hypertension.

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Section: Insomniamentioning

confidence: 93%

Treating sleep disorders to improve blood pressure control and cardiovascular prevention: a dream come true?—a narrative review

Maiolino¹,

Bisogni²,

Silvani³

et al. 2020

J Thorac Dis

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“…Several clinical studies have demonstrated that CM significantly increases the risk of cardiovascular disease in the young individuals [ 9 ]. However, heart disease is not reported in majority of the young and middle-aged working individuals who are diagnosed with CM [ 10 ]. Therefore, the underlying risk of cardiac dysfunction is not known for a large proportion of young people diagnosed with CM.…”

Section: Introductionmentioning

confidence: 99%

Harm of circadian misalignment to the hearts of the adolescent wistar rats

et al. 2022

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Purpose The purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the adolescent Wistar rats, and to explore the mechanisms leading to harm. Methods An IP was used to create a CM model. A total of 174 Wistar rats were randomly divided into circadian alignment (CA) and CM groups (87 rats per group). The different activity rhythms of the two groups of rats were adjusted through different light/dark cycles for 90 days. We recorded the rhythmic activity trajectory and sleep time of the rats. After 90 days of modeling, we performed various analyses (i.e., blood pressure, weight, cardiac ultrasound tests, serological tests, cardiac tissue immunofluorescence, immunohistochemistry, transmission electron microscopy on myocardial mitochondria, western blotting, and quantitative polymerase chain reactions). Results (1) The IP protocol caused CM in rats. (2) CM rats showed significantly higher blood pressure during the day (resting phase). They also showed significantly higher serum levels of angiotensin II and epinephrine during the day compared to the CA rats. (3) CM caused up-regulation of gene expression of adrenergic receptors α1 (α1-AR) and β1 (β1-AR) and down-regulation of the glucocorticoid receptor (Gr) gene expression in rat hearts. It also caused downregulation of Bmal1 expression. In addition, the changes in Bmal1 and Per2 correlated with the changes in β1-AR and α1-AR. (4) CM had adverse effects on multiple molecular proteins of the heart. (5) CM increased the collagen fibers in the rat heart and increased the destruction of mitochondria. (6) Eventually, CM caused a decrease in the pumping function of the heart and decreased the coronary blood flow rate. Conclusions (1) CM significantly affected the cardiac structure and function in the adolescent rats through a variety of mechanisms. (2) CM can regulate the expression of myocardial clock genes, and it is likely to have an impact on the heart through this pathway.

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“…A cross-sectional study of male workers in Iran found that a 12-hour rotating night-shift work schedule can be significantly associated with higher odds of high blood pressure. 29 A prospective cohort study among 2151 workers found workers with mostly night work and frequent rotations (≥50% night and ≥10% rotation) had the highest risk of high blood pressure when compared with non-night workers (hazard ratio, 4.00 [95% CI, 1.69-9.52]). 19 Meanwhile, a previous meta-analysis that included 45 studies involving 117,252 workers showed a significant increase in both SBP and DBP among perpetual night workers compared with non-night workers (2.52 [95% CI, 0.75-4.29] mmHg and 1.76 [95% CI, 0.41-3.12] mmHg, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Several previous epidemiological studies have found an increased risk for hypertension of night shifts. A cross-sectional study of male workers in Iran found that a 12-hour rotating night-shift work schedule can be significantly associated with higher odds of high blood pressure 29 . A prospective cohort study among 2151 workers found workers with mostly night work and frequent rotations (≥50% night and ≥10% rotation) had the highest risk of high blood pressure when compared with non-night workers (hazard ratio, 4.00 [95% CI, 1.69–9.52]) 19 .…”

Section: Discussionmentioning

confidence: 99%