The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population

Abstract

(1) Background: Inflammation plays a pivotal role in atherosclerosis, and the association between chronic inflammatory states and ischemic heart disease (IHD) has been shown in several rheumatic diseases. Persistent inflammation might also be a risk factor for IHD in sarcoidosis patients. (2) Methods: Demographic and clinical data of 3750 sarcoidosis patients and 18,139 age- and sex-matched controls were retrieved from the database of Clalit Health Services, Israel’s largest healthcare organization. Variables associated with IHD were assessed by a logistic regression model. To assess for variables that were related to increased risk of all-cause mortality, the Cox proportional hazards method was used, and a log-rank test was performed for survival analysis. (3) Results: Both groups were composed of 64% females with a median age of 56 years. An association between sarcoidosis and IHD was demonstrated by a multivariate analysis (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.36–1.66). Long-term follow-up revealed increased mortality among sarcoidosis patients: 561 (15%) deaths compared to 1636 (9%) deaths among controls (p < 0.001). Survival analysis demonstrated that sarcoidosis patients were also at increased risk for all-cause mortality compared to controls (multivariate model, adjusted HR 1.93; 95% CI 1.76–2.13).

RETRACTED: Association between sarcoidosis and cardiovascular Outcomes: A systematic review and Meta-analysis

“…A study conducted by Etinger and colleagues evaluated the mortality rates due to sarcoidosis in comparison to matched controls from 2000 to 2016; the authors found that there was higher mortality with sarcoidosis (17.8% vs. 10.7%, p < 0.001) [38] . Gonen and colleagues reported deaths with a mean follow-up of 68 months among 15% patients with sarcoidosis as opposed to 9% reported for the control group (9%) [39] . Mortality is multifactorial in the cardiac sarcoidosis, with the leading cause of mortality being heart failure, as reported by Yazkai et al [40] .…”

Acute Coronary Syndrome in a Patient with Sarcoidosis: A Case Report

“…The development of atherosclerosis and plaque instability may be aided by inflammation and fibrosis within the artery walls, raising the risk ofACS. 12 It was unexpected, nonetheless, for ACS to develop alongside sarcoidosis. 13 Our diagnosis was supported with initial findings of Nepalese Heart Journal 2024; Vol.…”

Cardiovascular risk in rare diseases: a prognostic stratification model in a cohort of sarcoidosis patients

“…As proof of the strong relationship between sarcoidosis and CV risk, a recent retrospective cross-sectional study on a large Israeli cohort of 3750 sarcoidosis patients and 18,139 age- and sex-matched controls highlighted that sarcoidosis was associated to ischemic heart disease (adjusted odds ratio 1.5; 95% confidence interval 1.36–1.66) and to increased risk for all-cause mortality compared to controls (adjusted hazard ratio 1.93; 95% confidence interval 1.76–2.13) [ 13 ].…”