The association between self-injurious behaviors and autism spectrum disorders

Minshawi, Noha F.; Hurwitz, Sarah; Fodstad, Jill C.; Biebl, Sara J. W.; Morriss, Danielle; McDougle, Christopher J.

doi:10.2147/prbm.s44635

Cited by 128 publications

(96 citation statements)

References 120 publications

(196 reference statements)

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“…RRSBs have great potential for harm when manifested as self-injurious behavior (SIB), which afflicts approximately one quarter of individuals with an ASD, ranging from head banging to self-directed biting and punching (Minshawi et al, 2014;Bartak and Rutter, 1976;Richards et al, 2012;Shattuck et al, 2007). A small subgroup of these patients demonstrates extremely highfrequency, high-intensity staccato-like repetitive SIB that has devastating consequences for the patient and their family (Wachtel and Dhossche, 2013).…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Chang

Berges

Chung

et al. 2015

Neuropsychopharmacol

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Approximately one quarter of individuals with an autism spectrum disorder (ASD) display self-injurious behavior (SIB) ranging from head banging to self-directed biting and punching. Sometimes, these behaviors are extreme and unresponsive to pharmacological and behavioral therapies. We have found electroconvulsive therapy (ECT) can produce life-changing results, with more than 90% suppression of SIB frequency. However, these patients typically require frequent maintenance ECT (mECT), as often as every 5 days, to sustain the improvement gained during the acute course. Long-term consequences of such frequent mECT started as early as childhood in some cases are unknown. Accordingly, there is a need for alternative forms of chronic stimulation for these patients. To explore the feasibility of deep brain stimulation (DBS) for intractable SIB seen in some patients with an ASD, we utilized two genetically distinct mouse models demonstrating excessive self-grooming, namely the Viaat-Mecp2 − /y and Shank3B −/− lines, and administered high-frequency stimulation (HFS) via implanted electrodes at the subthalamic nucleus (STN-HFS). We found that STN-HFS significantly suppressed excessive selfgrooming in both genetic lines. Suppression occurs both acutely when stimulation is switched on, and persists for several days after HFS is stopped. This effect was not explained by a change in locomotor activity, which was unaffected by STN-HFS. Likewise, social interaction deficits were not corrected by STN-HFS. Our data show STN-HFS suppresses excessive self-grooming in two autism-like mouse models, raising the possibility DBS might be used to treat intractable SIB associated with ASDs. Further studies are required to explore the circuitry engaged by STN-HFS, as well as other potential stimulation sites. Such studies might also yield clues about pathways, which could be modulated by non-invasive stimulatory techniques.

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Section: Introductionmentioning

confidence: 99%

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Chang

Berges

Chung

et al. 2015

Neuropsychopharmacol

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“…3 All of these behaviors can cause significant long-term physical damage in addition to short-term injury and pain and can have a negative impact on interpersonal relationships and quality of life. 4 A number of theories about the cause of SIB have been proposed, such as the inability to communicate needs. 4 SIB is profoundly difficult to manage, but psychotropic medication shouldn't be the first line of defense.…”

Section: Teresa Shannon Rn Bs Repliesmentioning

confidence: 99%

“…4 A number of theories about the cause of SIB have been proposed, such as the inability to communicate needs. 4 SIB is profoundly difficult to manage, but psychotropic medication shouldn't be the first line of defense. Initially, a complete physical assessment should be performed to identify any underlying physical cause for the behavioral disorder, such as infection or constipation.…”

Section: Teresa Shannon Rn Bs Repliesmentioning

confidence: 99%

Self-injury in patients with intellectual disability

Shannon

2016

Nursing

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“…Self-injurious behavior (SIB) is a broad term describing a behavior that causes (or potentially produces) physical harm to oneself [1][2][3]. These behaviors including head banging, head hitting and other behaviors that can cause physical trauma.…”

Section: Introductionmentioning

confidence: 99%

Self-injurious behavior among individuals with intellectual and developmental disabilities

Hagopian¹

2017

Acta Psychopathol

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Self-injurious behavior (SIB) is a broad term describing a behavior that causes (or potentially produces) physical harm to oneself. This behavior is described in individuals intellectual and developmental disabilities, including those with autism. SIB is a severe clinical condition that produces serious medical consequences and limits life opportunities for the persons and those who care for them. Research confirms that applied behavior analysis based approaches designed to identify controlling variables of SIB, can lead to effective interventions. Current knowledge indicates that across individuals, SIB varies along a continuum of relative environmental-biological influence. Additional research is needed to identify how medication can be used in concert with behavioral treatment, and to better understand the biological variables that are associated with the occurrence and maintenance of SIB.

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The association between self-injurious behaviors and autism spectrum disorders

Cited by 128 publications

References 120 publications

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models

Self-injury in patients with intellectual disability

Self-injurious behavior among individuals with intellectual and developmental disabilities

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