The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study

Abstract

Background Adropin, a newly‑identified energy homeostasis protein, has been implicated in the maintenance of metabolic homeostasis and insulin sensitivity. This study attempts to measure the association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This cross‑sectional study was performed in 503 hospitalized patients with T2DM.Serum adropin level was measured by a sandwich enzyme-linked immunosorbent assay. The carotid atherosclerosis was assessed by color Doppler sonography. The association between adropin and carotid atherosclerotic plaque was tested by logistic regression model. The effect of adropin on carotid intimal-medial thickness (CIMT) was estimated using linear regression model. Results Overall, 280 (55.7%) patients had carotid atherosclerotic plaque. The risk of carotid atherosclerotic plaque decreased with the increment of serum adropin level (adjusted odds ratio [aOR], 0.90; 95%CI: 0.81–0.99) in patients with T2DM. Serum adropin (Standardized β = − 0.006, p = 0.028) was also independently protective factor for CIMT in patients with T2DM. Conclusion In patients with T2DM, high serum adropin level was correlated with a decreased risk of carotid atherosclerosis in T2DM patients. Low circulating level of adropin may promote carotid atherosclerosis.

Association between metabolic score of visceral fat and carotid atherosclerosis in Chinese health screening population: a cross-sectional study

“…Notably, the METS-IR demonstrated efficacy in reflecting the severity of insulin resistance and was advantageous for evaluating adverse outcomes in patients with type 2 diabetes [ 22 ]. The main cause of type 2 diabetes is insulin resistance, which in turn contributes to atherosclerosis [ 36 , 37 ]. Furthermore, the mechanism underlying the association between METS-VF and CAS was hypothesised.…”

“…Long-term deposition of adipose tissue leads to the excretion of large amounts of non-esterified fatty acids, glycerol, hormones, and proinflammatory cytokines, which induce oxidative stress and endoplasmic reticulum stress, resulting in adipocyte loss, metabolic disturbances, and ultimately insulin resistance [ 38 ]. Insulin resistance is a known risk factor for CAS [ 36 , 37 ], and elevated fasting serum insulin levels are associated with intraplaque haemorrhage in carotid atherosclerotic lesions [ 39 – 41 ]. In addition, dipose tissue-associated inflammatory factors play an important role in the pathogenesis of CAS.…”

A Comparative Study Between The Levels of Adropin in Iraqi Women with Metabolic Syndrome and Diabetes

“…Diabetes and low blood Adropin levels trigger atherosclerosis; hence, their interaction may result in more severe atherosclerosis. Additional research is required to determine how Adropin, diabetes, and atherosclerosis are related causally [24,25,26]. Adropin participates in several biological processes and is controlled by various nutrients, including lipids and carbohydrates [27].…”

Feeding-induced hepatokines and crosstalk with multi-organ: A novel therapeutic target for Type 2 diabetes

“…Although the link between plasma Adropin levels, nutrition, and mealtime is lesser understood in people, plasma Adropin levels in nonhuman primates (constant monkeys) have also peaked at feeding times in available studies (15). In addition, levels of serum Adropin were decreased in patients with T2DM, and elevated circulating Adropin values are related to a decreased hazard of diabetes-related complications (16)(17)(18). Here, we summarize the crosstalk of feeding-induced hepatokines on multiple extra-liver organs (i.e., adipose tissue, pancreas, brain, and heart).…”