The association between serum anti-HSP27 levels with hypertriglyceridemia

Taheri-Bonakdar, Mahdi; Khazaee, Mahdieh; Saberi‐Karimian, Maryam; Tayefi, Maryam; Ghazizadeh, Hamideh; Moohebati, Mohsen; Ebrahimi, Mahmoud; Safarian, Mohammad; Nematy, Mohsen; Sahebkar, Amirhosein; Ghayour‐Mobarhan, Majid; Parizadeh, Seyed Mohammad Reza

doi:10.1016/j.tmsr.2020.04.001

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Whilst the levels of anti-HSP27-Ab were not associated with TC, HDL, and LDL, a negative correlation has been found between the antibody and TG in CHB patients. Consistent with these ndings, Taheri-Bonakdar et al reported a negative correlation between the level of the antibody and TG in patients diagnosed with hypertriglyceridemia [24] and a further study on sHSP27 found no correlation to TC, LDL, HDL levels in patients with dyslipidemia and diabetes type 2 [25]. Nevertheless, Xiang Chen et al reported that sHSP27-Anti-HSP27-Ab immune complexes might reduce plasma cholesterol by up-regulating lowdensity lipoprotein receptors [26].…”

Section: Discussionmentioning

confidence: 79%

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Yousefli

Meshkat²,

Ghayour‐Mobarhan³

et al. 2023

Ind J Clin Biochem

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BackgroundHeat Shock Protein 27 (HSP27), an anti-HBV factor, exists in the intracellular and extracellular spaces. Serum HSP27 (sHSP27) is an in ammatory modulator and is associated with elevated pro-in ammatory cytokines and with a higher likelihood of hepatocellular carcinoma. SHSP27 results in natural antibody production (anti-HSP27-Ab) that is more stable and easily detectable compared to sHSP27. We aimed to investigate any potential association between anti-HSP27-Ab level and chronic hepatitis B (CHB) progression and in ammation indicated by liver cell injury and HBV replication. MethodsThis cross-sectional study was conducted on 91 patients with CHB and 92 individuals without CHB. Following demographic data collection, anti-HSP27-Ab, serum lipids including total cholesterol, triglyceride, LDL-C, HDL-C, and aminotransferase levels were measured using enzymatic assays in participants' serum samples. HBV DNA was also measured by quantitative PCR in CHB patients. ResultsBivariate and multivariate analyses showed a signi cantly higher mean level of anti-HSP27-Ab in CHB than in healthy individuals (0.304 vs. 0.256AU/ml, P-value = 0.015). These levels held signi cant differences in the CHB subgroups of male patients, at the age of 50 years and above, non-smokers, patients with elevated aminotransferase levels, and hypotriglyceridemia (P-value < 0.05). However, no difference was found between the antibody levels and HBV DNA copies (P-value > 0.05). ConclusionThis study provides evidence that anti-HSP27 antibody levels can re ect the degree of liver necrosis indicated by aminotransferase levels. Regarding the higher incidence rate of HBV-associated complications in 50 to 60-year-old men, monitoring the antibody can be bene cial in managing this group of CHB patients, which deserves further investigation.

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Section: Discussionmentioning

confidence: 79%

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Yousefli

Meshkat²,

Ghayour‐Mobarhan³

et al. 2023

Ind J Clin Biochem

Self Cite

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show abstract

“…The relationship between the serum anti-HSP27 antibody titers and diabetes was not significant in 7 . A significant direct relationship has been observed between some factors such as hypertension 8 , obesity, body mass index, age, height, serum LDL-C, serum triglycerides, and serum total cholesterol 1 , hypertriglyceridemia 9 with serum anti-HSP27 antibody titers.…”

Section: Introductionmentioning

confidence: 99%

“…We did not find any studies that used machine learning techniques for the prediction of serum anti-HSP27 antibody levels using related factors such as demographic factors, chronic diseases, social factors, chemical parameters, etc. In previous studies, simple methods such as general linear models, case–control studies 1 , 20 , logistic regression, and simple statistical tests such as correlation tests, analysis of variance, Kruskal–Wallis test 1 , 5 – 9 were used.…”

Section: Introductionmentioning

confidence: 99%

Prediction of serum anti-HSP27 antibody titers changes using a light gradient boosting machine (LightGBM) technique

Talkhi,

Nooghabi,

Esmaily

et al. 2023

Sci Rep

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Previous studies have proposed that heat shock proteins 27 (HSP27) and its anti-HSP27 antibody titers may play a crucial role in several diseases including cardiovascular disease. However, available studies has been used simple analytical methods. This study aimed to determine the factors that associate serum anti-HSP27 antibody titers using ensemble machine learning methods and to demonstrate the magnitude and direction of the predictors using PFI and SHAP methods. The study employed Python 3 to apply various machine learning models, including LightGBM, CatBoost, XGBoost, AdaBoost, SVR, MLP, and MLR. The best models were selected using model evaluation metrics during the K-Fold cross-validation strategy. The LightGBM model (with RMSE: 0.1900 ± 0.0124; MAE: 0.1471 ± 0.0044; MAPE: 0.8027 ± 0.064 as the mean ± sd) and the SHAP method revealed that several factors, including pro-oxidant-antioxidant balance (PAB), physical activity level (PAL), platelet distribution width, mid-upper arm circumference, systolic blood pressure, age, red cell distribution width, waist-to-hip ratio, neutrophils to lymphocytes ratio, platelet count, serum glucose, serum cholesterol, red blood cells were associated with anti-HSP27, respectively. The study found that PAB and PAL were strongly associated with serum anti-HSP27 antibody titers, indicating a direct and indirect relationship, respectively. These findings can help improve our understanding of the factors that determine anti-HSP27 antibody titers and their potential role in disease development.

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Association Between Serum Levels of Anti-Heat Shock Protein-27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Yousefli

Meshkat²,

Mobarhan³

et al. 2022

Preprint

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Background Heat Shock Protein 27 (HSP27), an anti-HBV factor, exists in the intracellular and extracellular spaces. Serum HSP27 (sHSP27) is an inflammatory modulator and is associated with elevated pro-inflammatory cytokines and with a higher likelihood of hepatocellular carcinoma. SHSP27 results in natural antibody production (anti-HSP27-Ab) that is more stable and easily detectable compared to sHSP27. We aimed to investigate any potential association between anti-HSP27-Ab level and chronic hepatitis B (CHB) progression and inflammation indicated by liver cell injury and HBV replication. Methods This cross-sectional study was conducted on 91 patients with CHB and 92 individuals without CHB. Following demographic data collection, anti-HSP27-Ab, serum lipids including total cholesterol, triglyceride, LDL-C, HDL-C, and aminotransferase levels were measured using enzymatic assays in participants’ serum samples. HBV DNA was also measured by quantitative PCR in CHB patients. Results Bivariate and multivariate analyses showed a significantly higher mean level of anti-HSP27-Ab in CHB than in healthy individuals (0.304 vs. 0.256AU/ml, P-value = 0.015). These levels held significant differences in the CHB subgroups of male patients, at the age of 50 years and above, non-smokers, patients with elevated aminotransferase levels, and hypotriglyceridemia (P-value < 0.05). However, no difference was found between the antibody levels and HBV DNA copies (P-value > 0.05). Conclusion This study provides evidence that anti-HSP27 antibody levels can reflect the degree of liver necrosis indicated by aminotransferase levels. Regarding the higher incidence rate of HBV-associated complications in 50 to 60-year-old men, monitoring the antibody can be beneficial in managing this group of CHB patients, which deserves further investigation.

show abstract

The association between serum anti-HSP27 levels with hypertriglyceridemia

Cited by 3 publications

References 23 publications

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B

Prediction of serum anti-HSP27 antibody titers changes using a light gradient boosting machine (LightGBM) technique

Association Between Serum Levels of Anti-Heat Shock Protein-27 Antibody and Liver Cell Injury in Chronic Hepatitis B

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