The association between serum ferritin and blood pressure in adult women: a large cross-sectional study

He, Andong; Yang, Xiaofeng; Ding, Yuzhen; Sun, Lu; Shi, Meiting; Li, Ruiman

doi:10.1080/10641963.2022.2079667

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…In addition, a study indicated that serum ferritin was positively correlated to DBP in adult women, [47] but in our study, serum ferritin levels in females showed statistically associate with high SBP and hypertension, whereas had no association with DBP. Therefore, more researches are needed on the relationship between serum ferritin and DBP and SBP.…”

Section: Discussioncontrasting

confidence: 88%

Higher serum ferritins are associated with higher blood pressure: A cross-sectional study

Li,

Chen,

et al. 2024

Medicine

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The aim of the study was to investigate the association between serum ferritin and hypertension among American adults from National Health and Nutrition Examination Survey (NHANES) 1999 to 2018. A total of 16,125 participants were included. Weighted logistic regression and subgroup analyses were performed to explore the association. We found that serum ferritin was closely correlated to hypertension. Individuals with high serum ferritin were more likely to have higher systolic or diastolic blood pressure (SBP, DBP) than those with lower serum ferritin. Restricted cubic spline showed a significant non-linear association between serum ferritin and SBP/DBP. Higher level of serum ferritin (Q3 74.1–147 μg/L and Q4 > 147 μg/L) was found to have positive association with high SBP [Q3 (OR: 1.246, 95% CI:1.020–1.523), Q4 (OR: 1.354, 95% CI:1.096–1.674)], and hypertension [Q3 (OR: 1.283, 95% CI:1.099–1.499), Q4 (OR: 1.424, 95% CI:1.197–1.63)] in the whole population. In people aged between 20 and 60, subjects with high serum ferritin were significantly associated with a higher risk of hypertension, but in those over 60, the relationship between serum ferritin level and hypertension is negative. A non-linear association between serum ferritin and SBP, as well as DBP, was discovered. There was age difference in association between serum ferritin and hypertension in American adults, and further researches were needed to understand the mechanisms behind the difference.

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Section: Discussioncontrasting

confidence: 88%

Higher serum ferritins are associated with higher blood pressure: A cross-sectional study

Li,

Chen,

et al. 2024

Medicine

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“…Moreover, ferritin level was positively associated with Diastolic Blood Pressure (DBP) in the donors with serum ferritin less than 60 ng/mL. Previous studies found positive correlation between serum ferritin, diastolic blood pressure and other components of metabolic syndrome [24][25][26]. Oshaug, et al have reported that DBP was a predictor for ferritin level [27].…”

Section: Discussionmentioning

confidence: 96%

The Relationship between Serum Ferritin and Platelet Count in Yemeni Blood Donors

Boshra¹,

Wahid²

2023

Int J Blood Res Disord

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Background: Regular blood donation often cause iron deficiency. Changes of platelet count have been associated with iron deficiency anemia. We aimed to study the correlation between serum ferritin and platelet count in blood donors.Methods: Full blood count was measured by Sysmex-KX-21N Haematology Analyser. Serum ferritin was examined using electrochemiluminescence technology of Cobas e 411 Analyzer. Results:The only significant correlation between ferritin level and platelet count (r2 = 0.432, p = 0.012) demonstrated in blood donors whose serum ferritin was less than 60 ng/ mL. Conclusions:No significant association between ferritin and platelet count were found in healthy donors with ≥ or < 6 blood donations whereas the moderate positive association was found in blood donors with low ferritin concentration (< 60 ng/mL).

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“…High ferritin levels in patients with severe COVID-19 may represent hyperinflammation and cytokine storm and may serve as an important predictor of severe disease and mortality [7][8][9]. Ferritin level appears to be higher in hypertensive patients [10,11]. While the predictive ability of ferritin level was well studied in COVID-19 in the general population, its predictive ability has not been studied in hypertensive patients.…”

mentioning

confidence: 99%

Ferritin level predicts in-hospital mortality in hypertensive patients with COVID-19

Skakun

Seredyuk

2023

ZMJ

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Aim. This study aimed to establish the predictive ability of serum ferritin levels for severe / critical condition development, need for supplemental oxygen, and in-hospital mortality in hypertensive patients with COVID-19-associated pneumonia. Materials and methods. 135 unvaccinated patients hospitalized for COVID-19-associated pneumonia were enrolled in the study. 78.5 % of patients were hypertensive. Results. Among hypertensive patients, the median ferritin level at admission was 315.5 (169.0–396.0) ng/mL in patients with moderate condition, 374.0 (171.0–709.5) ng/mL in patients developed severe condition, and 489.0 (362.0–1128.5) ng/mL in patients developed critical condition (P = 0.03). Serum ferritin level at admission was higher in non-survivors (539.0 (440.0–1128.5) ng/mL) than that in survivors (332.5 (172.0–545.0) ng/mL, P = 0.02). Hypertensive patients who required supplemental oxygen had higher median serum ferritin level (446.0 (187.0–763.0) ng/mL) than patients without the requirement of supplemental oxygen (324.0 (165.0–401.0) ng/mL, P = 0.02). There was poor discrimination ability of ferritin level in the prediction of severe / critical conditions (AUC = 0.628, P = 0.02) and the need for supplemental oxygen (AUC = 0.629, P = 0.02). There was an acceptable discrimination ability of ferritin level in the in-hospital mortality prediction (AUC = 0.701, P = 0.03); the Youden index was 0.54, the associated criterion was >438.0 ng/mL with 83.3 % sensitivity and 70.7 % specificity. Ferritin level >438.0 ng/mL at admission was associated with a significant increase in in-hospital mortality (OR = 12.04 (2.47–58.62), P = 0.002). Conclusions. Serum ferritin level at hospital admission increases with the severity of COVID-19 in hypertensive patients. Serum ferritin level predicts in-hospital mortality in hypertensive patients. However, its predictive ability for the disease progression to severe/critical conditions and the need for supplemental oxygen is poor. A ferritin level of 438.0 ng/mL is proposed to be a cut-off value for the prediction of in-hospital mortality.

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The association between serum ferritin and blood pressure in adult women: a large cross-sectional study

Cited by 4 publications

References 26 publications

Higher serum ferritins are associated with higher blood pressure: A cross-sectional study

Higher serum ferritins are associated with higher blood pressure: A cross-sectional study

The Relationship between Serum Ferritin and Platelet Count in Yemeni Blood Donors

Ferritin level predicts in-hospital mortality in hypertensive patients with COVID-19

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