The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosisDependence on serum LDL levels

Armstrong, Victor W.; Cremer, P.; Eberle, E.; Manke, Amruta; Schulze, Friedrich; Wieland, Heinrich; Kreuzer, H; Seidel, D.

doi:10.1016/0021-9150(86)90099-7

Cited by 607 publications

(201 citation statements)

References 21 publications

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“…Patients with high levels of both LDL-C and Lp(a) were observed to have a 5-fold higher coronary risk [20]. In such cases, it remains unclear if both LDL-C and Lp(a) should be lowered, or if reducing only LDL-C would su ce to make Lp(a) less harmful.…”

Section: Discussionmentioning

confidence: 99%

The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

Örnek¹,

Murat²,

Duran³

et al. 2011

CIM

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Turkeye relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction AbstractPurpose: e present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a).Methods: e study included 52 CAD patients and a control group consisting of 38 individuals. e patients were classi ed into three groups based on the clinical form of CAD (stable angina pectoris, SAP, unstable angina pectoris,UAP, and myocardial infarction,MI), and were further divided into three groups based on CAD severity (1-, 2-and 3-vessel). Serum Lp(a) levels were monitored 4, 8, and 24 h, 10 and 30 days following acute MI in 18 patients.Results: Based on regression analysis, Lp(a) was not correlated with other lipoproteins or with risk factors of CAD, such as body mass index, smoking, family history, diabetes, age, gender, and hypertension (r = 0.08-0.22). 72% of the patients in the CAD group and 24% of the control group had an Lp(a) level >30 mg dL -1 (P = 0.004), and Lp(a) levels were higher in 3-vessel patients than in 2-vessel and 1-vessel CAD patients (86% vs. 68%, P = 0.02 and 86% vs. 62%, P=0.01, respectively). Serum Lp(a) levels were higher in the UAP and MI groups than in the SAP group (48 ± 44.7 mg dL -1 , 49 ± 36.1 mg dL -1 and 31.2 ± 22.3 mg dL -1 , respectively,P=0.02). Lp(a) levels increased a er acute MI, and reached peak levels 10 days post-MI (41% increase, P=0.001) and remained considerably elevated (18%) 30 days post-MI (P=0.01).Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1-and 2-vessel CAD patients.

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Section: Discussionmentioning

confidence: 99%

The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

Örnek¹,

Murat²,

Duran³

et al. 2011

CIM

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“…Several studies have described a correlation between high Lp(a) plasma levels and coronary heart disease, stroke, and peripheral atherosclerosis. [27] Shoji et al have found the median Lp(a) level to be significantly higher in a group of CAPD patients with ischemic heart disease. [28] Markedly elevated Lp(a) levels in CAPD patients have been reported.…”

Section: Discussionmentioning

confidence: 99%

Effect of Peritoneal Dialysis Solution Type on Serum Lipid Levels in End-Stage Renal Disease

et al. 2007

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Among the different cardiovascular risk factors, lipid abnormalities dominate the high mortality in chronic ambulatory peritoneal dialysis patients. So far, no data comparing the effect of standard glucose-containing, amino acid-containing, and icodextrin-containing peritoneal dialysis solutions on serum lipid concentrations in a chronic ambulatory peritoneal dialysis population are available. To determine the effect of peritoneal dialysis solutions on parameters of lipid metabolism, 67 subjects who had continued their usual dialysis for the last six months were enrolled in the study. Group A consisted of 18 patients who were receiving only glucosebased peritoneal dialysis solutions, group B consisted of 18 patients who were receiving glucose and amino acid-based peritoneal dialysis solutions, and group C consisted of 31 patients who were receiving glucose and icodextrin-based peritoneal dialysis solutions. Serum lipid parameters including total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride, and lipoprotein (a) were determined in all groups. No significant difference in serum lipid parameters was found between groups A, B, and C. These results demonstrate the lack of the effect of amino acid or icodextrin-based peritoneal solutions on dyslipidemia of CAPD patients.

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“…Armstrong and colleagues 32 reported that the combination of high Lp(a) plasma concentrations and LDL cholesterol levels above the group median amplified the risk of coronary artery disease 6-fold. Therapeutic lowering of LDL cholesterol by Ն10% was found to dilute the predictive value of high Lp(a) for coronary artery disease.…”

Section: Kronenberg Et Al Lp(a) Apo(a) Phenotype and Atherogenesismentioning

confidence: 99%

Role of Lipoprotein(a) and Apolipoprotein(a) Phenotype in Atherogenesis

et al. 1999

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Background-Experimental studies have suggested both atherogenic and thrombogenic properties of lipoprotein (a) [Lp(a)], depending on Lp(a) plasma concentrations and varying antifibrinolytic capacity of apolipoprotein(a) [apo(a)] isoforms. Epidemiological studies may contribute to assessment of the relevance of these findings in the general population. Methods and Results-This study prospectively investigated the association between Lp(a) plasma concentrations, apo (a) phenotypes, and the 5-year progression of carotid atherosclerosis assessed by high-resolution duplex ultrasound in a random sample population of 826 individuals. We differentiated early atherogenesis (incident nonstenotic atherosclerosis) from advanced (stenotic) stages in atherosclerosis that originate mainly from atherothrombotic mechanisms. Lp(a) plasma concentrations predicted the risk of early atherogenesis in a dose-dependent fashion, with this association being confined to subjects with LDL cholesterol levels above the population median (3.3 mmol/L). Apo(a) phenotypes were distributed similarly in subjects with and without early carotid atherosclerosis. In contrast, apo(a) phenotypes of low molecular weight emerged as one of the strongest risk predictors of advanced stenotic atherosclerosis, especially when associated with high Lp(a) plasma concentrations (odds ratio, 6.4; 95% CI, 2.8 to 14.9). Conclusions-Lp(a) is one of the few risk factors capable of promoting both early and advanced stages of atherogenesis.Lp(a) plasma concentrations predicted the risk of early atherogenesis synergistically with high LDL cholesterol. Low-molecular-weight apo(a) phenotypes with a putatively high antifibrinolytic capacity in turn emerged as one of the leading risk conditions of advanced stenotic stages of atherosclerosis.

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The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosisDependence on serum LDL levels

Cited by 607 publications

References 21 publications

The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

Effect of Peritoneal Dialysis Solution Type on Serum Lipid Levels in End-Stage Renal Disease

Role of Lipoprotein(a) and Apolipoprotein(a) Phenotype in Atherogenesis

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