The Association between Serum Matricellular Protein: Secreted Protein Acidic and Rich in Cysteine-Like 1 Levels and Ischemic Stroke Severity

Serum Secreted Protein Acidic and Rich in Cysteine-Like 1 as a Biochemical Predictor for Prognosticating Clinical Outcomes After Acute Supratentorial Intracerebral Hemorrhage: A Prospective Cohort Study

“…In a study of patients with acute ischemic stroke, serum SPARCL1 concentrations were verified to be positively correlated with clinical severity, when patients were dichotomized into the two groups (namely, admission NIHSS scores <5 versus ≥6), and moreover, serum SPARCL1 was found to be an independent predictor for stroke severity (ie, admission NIHSS scores ≥6). 20 In another study of humans with severe traumatic brain injury, whether Glasgow coma scale was considered as a continuous variable, or transformed into a categorical variable, serum SPARCL1 levels were still independently related to Glasgow coma scale scores. 21 Our study showed that serum SPARCL1 levels were independently correlated with NIHSS scores and hematoma volume after acute ICH.…”

“… 19 Notably, there was a close correlation between serum SPARCL1 levels and severity indicated by baseline NIHSS score following acute ischemic stroke. 20 Alternatively, serum SPARCL1 levels were independently related to in-hospital mortality and admission traumatic severity reflected by Glasgow coma scale scores among patients with severe traumatic brain injury. 21 Herein, our study was designed to ascertain longitudinal change of serum SPARCL1 levels after acute ICH and further to discern its association with long-term functional outcome and END in a cohort of humans with acute ICH.…”

Association of serum secreted protein acidic and rich in cysteine-like protein 1 with metabolic measures and dyslipidemia among Chinese adults

“…It has been found that Sparcl1 is frequently downregulated in many cancers, including colorectal carcinoma ( 14 ), prostate cancers ( 15 ), pancreatic cancer ( 16 ), etc., suggesting its potential role as a tumor suppressor ( 17 ). In addition, Sparcl1 was also found to be independently associated with ischemic stroke severity in 132 patients with acute ischemic stroke ( 5 ). The Baltimore Longitudinal Study of Aging indicated that cognitively normal minor allele carriers of rs7695558 and rs9998212 , which were both associated with lower brain Sparcl1 gene expression, showed accelerated memory loss or atrophy of brain volumes ( 6 ).…”

“…This is the first study found that serum Sparcl1 was significantly associated with decreased prevalent risk of hypertriglyceridemia and dyslipidemia in Chinese adults, suggesting the importance of Sparcl1 in the metabolic regulation, especially lipid metabolism. Considering the potential effect of sparcl1 on the development of cancer and cardiovascular disease ( 2 , 3 , 5 ), the current study excluded participants with cancer or cardiovascular disease. Therefore, our results on the association of Sparcl1 and dyslipidemia could exclude the influence of these comorbidities to some extent.…”