2019
DOI: 10.1111/andr.12568
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The association between serum total testosterone and progression of hyperglycemia: a 15‐year prospective cohort study

Abstract: Background: The association between low testosterone concentration and increased risk of hyperglycemia in men has been demonstrated in observational and interventional studies. However, considering a variety of confounding factors, limited population-based studies have so far been conducted. Also, no information is available regarding the effect of testosterone on progressive development of dysglycemia. Objective: To examine the effect of total testosterone on development of pre-diabetes/diabetes in normoglyce… Show more

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Cited by 8 publications
(9 citation statements)
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“…In a prospective clinical study, Minooee et al. detected that low testosterone levels were related to the development of prediabetes but could not find a relationship between the conversion of prediabetes to T2DM [ 22 ]. In the present study, we could show that especially in prediabetic men there is a significant relationship between testosterone and metabolic profiles.…”
Section: Discussionmentioning
confidence: 99%
“…In a prospective clinical study, Minooee et al. detected that low testosterone levels were related to the development of prediabetes but could not find a relationship between the conversion of prediabetes to T2DM [ 22 ]. In the present study, we could show that especially in prediabetic men there is a significant relationship between testosterone and metabolic profiles.…”
Section: Discussionmentioning
confidence: 99%
“…Insulin resistance and elevated leptin levels in patients with T2D are known to be related to low testosterone levels [1,2] It has been proposed that insulin resistance causes hypogonadism through its relationship with leptin, an adipocyte-derived hormone and a recognized modulator of the hypothalamic-pituitary-gonadal axis [3,17] Hyperglycemia, caused by insulin resistance, induces an increase in leptin levels to reduce blood glucose levels [18,19] Persistently elevated leptin levels reported in patients with T2D, especially in obese men, may be responsible for the suppression of gonadal function [20,21] Testosterone levels in T1D patients are different from those in T2D patients because T1D is related to insulin deficiency rather than insulin resistance. Another mechanism not related to insulin or leptin may exist with respect to testosterone levels in T1D patients.…”
Section: Discussionmentioning
confidence: 99%
“…Although theoretically, bioavailable testosterone is the most accurate parameter to identify testosterone deficiency, because a standard method to measure this parameter has not been established, total testosterone is the most widely accepted substitute parameter. 38,39 However, it should be noted that the use of total testosterone level for the diagnosis of hypogonadism in elder individuals may result in under-diagnosis because SHBG increases with age and albumin decreases. 40 Although testosterone levels in male adults decrease with aging (approximately 0.12 nmol/L per year), 41,42 it is progressive throughout life and there is no set point in women during menopause.…”
Section: Discussionmentioning
confidence: 99%