The Association between Serum Vitamin D Concentration and Colon Polyp: A Cross-Sectional Study Using Health Care Screening Database in a Tertiary Hospital in Korea

Yoo, Mun Young; Lee, Jungkwon; Chung, Ji In; Yeo, Yohwan; Cho, In Young

doi:10.4082/kjfm.20.0181

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…A total of 3,129 articles were retrieved from the databases and reference lists during the initial screening process. After a full-text review, 28 studies were included for qualitative analysis, among which four studies reported the same population ( 13 , 14 , 16 , 25 ), so 24 studies were left for meta-analysis ( 15 , 17 , 18 , 26 – 46 ). Table 1 summarized the basic characteristics of each study.…”

Section: Resultsmentioning

confidence: 99%

“…Vitamin D: 10 studies investigated the association between vitamin D and the risk of SPs ( 18 , 28 , 29 , 31 , 34 , 37 , 38 , 42 , 43 , 45 ). The forest plot illustrated a close-to-significant decreased risk of SPs with increased levels of vitamin D intake (OR = 0.95, 95%CI:0.90–1.02), and statistically significant heterogeneity was found ( I 2 = 54.9%; P = 0.018) ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis

Zhu¹,

Guan²,

Liu³

et al. 2023

Front. Nutr.

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BackgroundDietary factors may affect the incidence of colorectal serrated polyps (SP). However, its effects on SP are unclear as epidemiological studies on this topic have showed inconsistent results. The present systematic review and meta-analysis sought to evaluate the effects of dietary factors on SPs.MethodsStudies regarding the association between dietary factors and SPs were identified by searching PubMed, Cochrane library, Embase and Chinese Biomedical Literature database from inception until 27 February 2023. Search terms include serrated, hyperplastic, adenoma, polyps, colorectal, rectal, rectum and risk. Heterogeneity was assessed using I2 statistics. The meta-analysis was conducted by using a random-effects model, and the pooled effects were expressed with odds ratios (OR) and 95% confidence intervals (95% CI). Probable sources of heterogeneity were identified through meta-regression. Subgroup analysis were based on lesion types, study designs, countries, and so on.Results28 studies were ultimately eligible after scanning, and five dietary factors including vitamin D, calcium, folate, fiber and red or processed meat were excerpted. Higher intakes of vitamin D (OR = 0.95, 95%CI:0.90–1.02), calcium (OR = 0.97, 95%CI: 0.91–1.03) and folate (OR = 0.82, 95% CI: 0.6–1.13) were not significantly associated with SP. Fiber intake (OR = 0.90, 95% CI: 0.82–0.99) was a protective factor against SPs. Red meat intake increased the risk of SPs by 30% for the highest versus lowest intakes (OR = 1.30, 95% CI: 1.13–1.51). For different lesion types, higher folate intake was associated with a decreased risk of HPs (OR = 0.59, 95%CI: 0.44–0.79), and higher vitamin D intake decreased the risk of SPs including SSA/P (OR = 0.93, 95%CI: 0.88–0.98).ConclusionsHigher dietary fiber intake plays an effective role in preventing SP, while red meat intake is associated with an increased risk of SP. This evidence provides guidance for us to prevent SP from a dietary perspective.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, RecordID=340750.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis

Zhu¹,

Guan²,

Liu³

et al. 2023

Front. Nutr.

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“…A previous study suggested that the inverse association between circulating 25(OH)D and adenomas does not apply to hyperplastic polyps [ 8 ]. However, another study in 2021 did not find evidence for an association between vitamin D and overall colorectal polyps, but observed a trend for decreased odds of hyperplastic polyps with increased vitamin D levels [ 59 ]. The research variables of the above study were quite different from our study, which suggested that Vitamin D deficiency increased the risk of CRPs, especially nonadenomatous polyps.…”

Section: Discussionmentioning

confidence: 99%

Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

Chiang¹,

Chang²,

He³

et al. 2023

PLoS ONE

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Background Studies have revealed the association of vitamin D with specific types of cancer development, however, its correlation with colorectal polyps (CRPs) remains unverified. Our study aimed to investigate the relationship between vitamin D levels, metabolic factors, and CRPs. Methods A cross-sectional study from 2017 to 2019 involving 1306 participants was conducted to investigate the association among vitamin D levels, metabolic factors, uric acid and CRPs in Taiwan. CRPs diagnoses were determined via colonoscopies conducted by experienced gastrointestinal physicians, and biopsied polyps were inspected under a microscope by experienced pathologists. We employed both simple and multiple logistic regression analyses to identify significant factors associated with CRPs and adenomatous polyps, respectively. Results Our result showed that the prevalence of 25(OH)-vitamin D deficiency (≦ 20 ng/mL) and CRPs was 21.21% and 40.89%, respectively. Multiple logistic regression revealed that the risk of CRPs increased with old age, male sex, hyperglycemia, high triglyceride levels, and low 25(OH)D levels after adjustment for other factors. Besides, low 25(OH)D levels were significantly associated with CRPs risk in women, whereas elevated blood pressure was associated with CRPs risk in men. 25(OH)D Deficiency was revealed to be significantly associated with risk of CRPs in adults over 50 years old. Compared to nonadenomatous polyps, older age, higher 25(OH) vitamin D and higher uric acid levels were at increased risk for adenomatous polyps. Conclusions Our study revealed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women. We should therefore be concerned about the CRP risk of vitamin D deficiency and metabolic syndrome (especially hyperglycemia, elevated blood pressure in men, and high triglyceride levels) in this population.

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“…2A. It is thought that the discrimination power can be improved by learning more data or adding factors such as CBC 24 , blood vitamin D concentration 25,26 , and blood lipid profile 27,28 , which are weak but known risk factors for polyps as it is included in general health examinations.…”

Section: Discussionmentioning

confidence: 99%

Prospective pilot trial for evaluating the feasibility of an artificial intelligence algorithm for predicting the risk of colorectal adenoma using health screening questionnaire

You,

Jung,

Han

et al. 2023

J Innovative Medical Technology

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Background: In colorectal cancer (CRC) screening, artificial intelligence (AI)-based software was developed to predict the risk of adenomas to compensate for the inconvenience and low sensitivity of fecal occult blood tests. This study investigates the applicability of this program for predicting risk using health-screening questionnaire data collected in real clinical settings. Materials and Methods: Using a questionnaire accessible through web/mobile applications, data were collected from 516 examinees from an institution. The risk of colorectal adenoma and high-risk adenomas was then predicted by applying the AI-based algorithm, and the accuracy of the predictions evaluated by comparison with colonoscopy and pathology results. Additionally, the satisfaction survey of the examinees with the use of the program was investigated. Result: The subjects were 49.7% male, median age was 59 years, 35.2% had body mass index over 25, family history of CRC was 8.6%, smoking was 39.7%, and alcohol consumption was 53.2%. Pathological results showed that adenomas were diagnosed in 42.2%, high-risk adenomas in 6.3%, and cancer in 4 patients (0.8%). There was a significant difference in the risk score between the adenoma positive and negative groups (40.8 vs 35.8, P≤0.001), and the accuracy of predicting risk of adenoma was 60.3%. The satisfaction survey received a positive response score of 75% or more. Conclusion: Using a questionnaire in the form of familiar applications has the potential to supplement current screening methods, and is expected to be used in the future for effective CRC prevention through continuous data learning.

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The Association between Serum Vitamin D Concentration and Colon Polyp: A Cross-Sectional Study Using Health Care Screening Database in a Tertiary Hospital in Korea

Cited by 8 publications

References 26 publications

Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis

Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis

Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

Prospective pilot trial for evaluating the feasibility of an artificial intelligence algorithm for predicting the risk of colorectal adenoma using health screening questionnaire

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