The association between shift work and the incidence of reflux esophagitis in Korea: a cohort study

Abstract

Shift work has adverse health effects such as diabetes, cardiovascular disease, sleep disturbance, depression, and breast cancer. Gastro-esophageal reflux disease (GERD) results in lesions such as reflux esophagitis (RE) and Barrett’s esophagus. This study investigated the association between shift work and RE. A cohort study was conducted with 140,553 participants who were followed up at least once from 2012 to 2018. Type of working and shift types were collected using standardized questionnaires. Esophagogastroduodenoscopy (EGD) was performed by experienced endoscopists who were blinded to the aims of this study. According to the Los Angeles classification, RE was categorized based on the extent of esophageal mucosal breaks. During the 469,217.2 person-years of follow-up, 35,185 participants developed incident cases of RE. The multivariable adjusted hazard ratio (95% confidence intervals) for incident cases comparing shift work to fixed day work was 1.09 (1.04–1.13). This association was more strongly observed in the younger age group (18–39 years old) and the female group. In conclusion, shift work was significantly associated with the incidence of RE. Particularly, the results were more significant in the younger and female groups.

Association between circadian syndrome and chronic diarrhea: a cross-sectional study of NHANES 2005–2010 data

“…For bowel health, recent evidence has confirmed that circadian rhythms can influence the gut microbiota and microbial composition in terms of driving inflammation and hormonal responses ( Teixeira et al, 2020 ; Lotti et al, 2023 ). Population-based studies have also highlighted close relationships between circadian rhythms and bowel health, e.g., shift work appears to partly increase the risk of functional gastrointestinal disease ( Koh et al, 2014 ), peptic ulcer disease ( Knutsson and Bøggild, 2010 ), and reflux esophagitis ( Nam et al, 2023 ).…”