The association between systemic inflammatory markers and sarcopenia: Results from the West China Health and Aging Trend Study (WCHAT)

Zhao, Wenchuan; Zhang, Yan; Hou, Lisha; Xia, Xin; Ge, Meiling; Liu, Xiaolei; Yue, Jirong; Dong, Birong

doi:10.1016/j.archger.2020.104262

Cited by 45 publications

(33 citation statements)

References 30 publications

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“…At the same time, sarcopenia seems to be characterized by a low-degree systemic inflammation with increased levels of pro-inflammatory cytokines. Together, these data are in line with the literature [ 12 , 15 , 29 , 32 , 37 ] which underlines the correlation between sarcopenia and the presence of a basal inflammatory status.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, several studies have demonstrated high levels of inflammatory markers and/or pro-inflammatory cytokines in sarcopenic patients, thus suggesting that the inflammatory substrate may have a significant role in the development of sarcopenia itself, as high levels of inflammatory cytokines and acute phase reactant could initiate various molecular pathways in skeletal muscle. Neutrophil/lymphocyte ratio (NLR), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP) are the markers most frequently associated with sarcopenic status and they could be considered as risk factors for the development of sarcopenia itself [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Sarcopenia and Inflammation on Patients with Advanced Non-Small Cell Lung Cancer (NCSCL) Treated with Immune Checkpoint Inhibitors (ICIs): A Prospective Study

Tenuta

Pandozzi

Sirgiovanni

et al. 2021

Cancers

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Background: Sarcopenia is a condition characterized by loss of skeletal muscle mass associated with worse clinical outcomes in cancer patients. Data on sarcopenia in patients undergoing immune checkpoint inhibitors (ICI) therapy are still limited. The aim of this prospective observational study was to investigate the relationship between sarcopenia, ICI treatment response and immunological profile, in patients with advanced non-small cell lung cancer (NSCLC). Methods: Forty-seven stage IV NSCLC patient candidates for starting ICI, were enrolled from the Policlinico Umberto I outpatient Oncology. Patients underwent baseline blood test, inflammatory markers, cytokine assessment and body composition with dual-energy X-ray absorptiometry (DXA). Sarcopenia was defined with appendicular skeletal muscle mass over height2 (ASM/heigh2). Results: Overall, 19/47 patients (40.4%) results were sarcopenic. Sarcopenic patients showed significantly shorter PFS than non-sarcopenic ones (20.3 weeks, 95% CI 7.5–33.1 vs. 61 weeks, 95% CI 22.5–99.4, p = 0.047). Specifically, they had an 8.1 times higher risk of progression disease (PD) than non-sarcopenic patients (OR 8.1, 95%, p = 0.011). Conclusions: Sarcopenic patients showed worse PFS and had a higher risk of PD compared to non-sarcopenic ones. Therefore, sarcopenia may reflect the increased metabolic activity of more aggressive tumors, which involves systemic inflammation and muscle wasting and could be considered a negative predictive factor for ICI response.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impact of Sarcopenia and Inflammation on Patients with Advanced Non-Small Cell Lung Cancer (NCSCL) Treated with Immune Checkpoint Inhibitors (ICIs): A Prospective Study

Tenuta

Pandozzi

Sirgiovanni

et al. 2021

Cancers

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“…White blood cell count is a strong indicator of low-grade in ammation and also might interfere with muscle metabolism by producing pro-in ammatory cytokines like IL-6 [20,21]. However, our study did not nd any signi cant association between WBC count and sarcopenia; even PLT and PWR have been shown to have a signi cant association.…”

Section: Discussioncontrasting

confidence: 82%

Association Between Platelet, White Blood Cell Count, Platelet To White Blood Cell Ratio and Sarcopenia in Community-Dwelling Older Adults: Focus On Bushehr Elderly Health (BEH) Program

Gholizade

Farhadi

Marzban

et al. 2021

Preprint

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Background Sarcopenia is a progressive age-related skeletal muscle disorder associated with harmful impacts on health. The present study aimed to investigate the relation between sarcopenia, platelet (PLT), white blood cell (WBC), and PLT to WBC ratio (PWR) due to the importance of early sarcopenia diagnosis. Methods This cross-sectional study was conducted based on the second stage of the Bushehr Elderly Health (BEH) Program. Sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) in accordance with the Iranian cut-off point. Univariate and adjusted multivariate logistic regression and linear regression were used to evaluate the associations. Results The prevalence of sarcopenia among participants was 35.73 %. PLT count and PWR were statistically higher in severe sarcopenic participants, while no differences were seen in WBC. In crude analysis, sarcopenia was not associated with quartiles of PLT, WBC, and PWR, while after adjusting for age, marital status, and sex, the association was seen in the fourth quartile of PLT and PWR [OR (95%CI) = 1.40 (1.08 to 1.81), p-value = 0.009 for PLT; OR (95%CI) = 1.55 (1.20 to 2.00), p-value = 0.001 for PWR]. This association remained significant in the fully adjusted model [OR (95%CI) = 1.92 (1.25 to 2.95), p-value = 0.003 for PLT; OR (95%CI) = 1.64 (1.06 to 2.52), p-value = 0.024 for PWR]. Among sarcopenia parameters, PLT count was more likely to be associated with handgrip strength and muscle mass. After stratifying the participants by gender, sarcopenia parameters were no longer statistically significant in men. Conclusion This study showed that PLT and PWR were associated with sarcopenia after considering confounding factors, while this association was not seen in WBC. Moreover, results showed that gender had an important impact on sarcopenia parameters.

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“…Higher TNF-a and its soluble receptors investigated the most consistent relationship with lower grip strength and muscle mass 12 . Zhao et al In a crosssectional study on middle-aged and older adults indicated a higher platelet-to-lymphocyte ratio (PLR), neutrophil-tolymphocyte ratio (NLR), and systemic immune-in ammation index (SII), were associated with increased odds of sarcopenia 15 . In support of these ndings, a systematic review and meta-analysis that evaluated the association of markers of in ammation with muscle strength and muscle mass found a signi cant relationship between increased levels of circulating TNF-α, CRP, and IL-6 with a decline in muscle mass, handgrip and knee extension strength 16 .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokines and Sarcopenia in Iranian Adults-results from SARIR Study

Asoudeh¹,

Dashti²,

Raeesi³

et al. 2021

Preprint

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Background Some studies emphasize the effects of inflammatory cytokines in reducing muscle mass and muscle strength and performance. This study aimed to compare pro-inflammatory cytokines in sarcopenic and non-sarcopenic subjects. Method The present study used data from the "Sarcopenia and its Determinants Among Iranian Elders" (SARIR) study. Three hundred men and women aged ≥ 55 years old who lived in the 6th district of Tehran were selected using random cluster sampling. We measured all components by using standard protocols, in addition we defined sarcopenia based on former and new European Working Group on Sarcopenia in Older People (EWGSOP) guidelines. A fasting blood sample was taken from each participant to measure serum high-sensitivity C-reactive protein (hs- CRP), Interleukin 6 (IL-6), and tumor necrosis factor α (TNFα). Results Mean age and body mass index (BMI) of study participants were 66.7 ± 7.7 years and 27.3 ± 4.2 kg/m2, respectively. Thirty-one participants of the present study had the criteria of EWGSOP2-sarcopenia. A statistically significant difference was seen between normal and abnormal groups of muscle strength in hs-CRP (p-value =0.04). Furthermore, we did not observe a remarkable association between inflammatory biomarkers including IL-6, TNF-α and hs-CRP and risk of sarcopenia even after controlling for plausible confounders (OR: 1.15; 95% CI 0.31-4.28, OR 0.68; 95% CI 0.17-2.77 and OR 2.39; 95% CI 0.87-6.55). Conclusion We found that inflammatory biomarkers level was not considerably associated with odds of sarcopenia. Lack of correlation between inflammatory cytokines and sarcopenia could be due to participant’s age and genetic. Future studies are required to confirm these findings.

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The association between systemic inflammatory markers and sarcopenia: Results from the West China Health and Aging Trend Study (WCHAT)

Cited by 45 publications

References 30 publications

Impact of Sarcopenia and Inflammation on Patients with Advanced Non-Small Cell Lung Cancer (NCSCL) Treated with Immune Checkpoint Inhibitors (ICIs): A Prospective Study

Impact of Sarcopenia and Inflammation on Patients with Advanced Non-Small Cell Lung Cancer (NCSCL) Treated with Immune Checkpoint Inhibitors (ICIs): A Prospective Study

Association Between Platelet, White Blood Cell Count, Platelet To White Blood Cell Ratio and Sarcopenia in Community-Dwelling Older Adults: Focus On Bushehr Elderly Health (BEH) Program

Inflammatory Cytokines and Sarcopenia in Iranian Adults-results from SARIR Study

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