The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis

Yao, Lei; Qiu, Lixin; Yu, Li-Fang; Yang, Zhen; Yu, Xinzhe; Zhong, Yang; Liu, Yu

doi:10.1007/s10549-010-0742-1

Cited by 21 publications

(10 citation statements)

References 25 publications

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“…Furthermore, one study showed a decreased risk of UGT1A1*28 for breast cancer in Nigerian women (Huo et al 2008). A meta-analysis study published in 2010 (Yao et al 2010), which aggregated 5,746 cases and 8,365 controls from most of these studies, concluded that there was evidence for enhanced risk for breast cancer in Caucasian women with the UGT1A1*28 allele. Consequently our finding of lower BPA glucuronidation in breast tissue with the UGT1A1*28 may explain in part these observations of enhanced breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

et al. 2016

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Bisphenol-A is a ubiquitous environmental contaminant that is primarily metabolized by glucuronidation and associated with various human diseases including breast cancer. Here we identified UDP-glucuronosyltransferases (UGTs) and genetic polymorphisms responsible for interindividual variability in bisphenol-A glucuronidation in human liver and breast.Hepatic UGTs showing the highest bisphenol-A glucuronidation activity included UGT2B15 and UGT1A9. Relative activity factor normalization indicated that UGT2B15 contributes >80% of activity at bisphenol-A concentrations under 5 µM, while UGT1A9 contributes up to 50% of activity at higher concentrations.Bisphenol-A glucuronidation by liver microsomes (46 donors) ranged from 0.25 to 4.3 nmoles/min/mg protein. Two-fold higher glucuronidation (P = 0.018) was observed in UGT1A9 *22/*22 livers compared with *1/*1 and *1/*22 livers. However, no associations were observed for UGT2B15*2 or UGT1A1*28 genotypes.Bisphenol-A glucuronidation by breast microsomes (15 donors) ranged from <0.2 to 56 fmoles/min/mg protein. Breast mRNA expression of UGTs capable of glucuronidating bisphenol-A was highest for UGT1A1, followed by UGT2B4, UGT1A9, UGT1A10, UGT2B7 and UGT2B15. Bisphenol-A glucuronidation was over 10-fold lower in breast tissues with the UGT1A1*28 allele compared with tissues without this allele (P = 0.006).UGT2B15 and UGT1A9 contribute to glucuronidation variability in liver, while UGT1A1 is important in breast.

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Section: Discussionmentioning

confidence: 99%

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

et al. 2016

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“…We selected polymorphisms that were associated with breast cancer risk in some, but not all, studies. The following polymorphisms were genotyped: SHBG rs6259 [5], [8], [18], [19], [20]; PGR rs1042838 [11], [20], [21], [22], [23], [24], [25]; ESR1 rs2234693 [20], [26], [27], [28], CYP19 rs10046 and rs4775936 [5], [7], [20], [29], [30], [31], [32], [33]; and UGT1A1 rs8175347 [34], [35], [36], [37], [38], [39].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

et al. 2013

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Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.

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“…However, the results from our study did not indicate a correlation between the UGT1A1*28 polymorphism and breast cancer risk. Such controversial results have also been reported by previous studies and are speculated to result from inter-ethnic and regional variations in the UGT1A1*28 polymorphism (Kaniwa et al, 2005;Yao et al, 2010). For example, the frequency of homozygous and heterozygous UGT1A1*28 genotypes is approximately 10-15 and 35-50%, respectively, in Caucasians (Beutler et al, 1998;Innocenti et al, 2002).…”

Section: Discussionmentioning

confidence: 63%

“…A previous study involving 200 African American women with breast cancer and 200 healthy controls demonstrated a strong association between the incidence of breast cancer and the UGT1A1*28 polymorphism, and a stronger association between this incidence and menopause and ER status (Guillemette et al, 2000). However, this association was not observed in a Chinese population (Adegoke et al, 2004;Yao et al, 2010). Further stratification by age showed a correlation between the UGT1A1*28 risk allele and a slight elevation in breast cancer risk in Chinese women less than 40 years of age (Adegoke et al, 2004).…”

Section: Introductionmentioning

confidence: 79%

Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women

Shi

Duan

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Breast cancer is among the most common causes of cancerrelated death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the UGT1A1 locus. UGT1A1*28 has been previously linked to increased risk of breast cancer. The aim of this study was to elucidate the possible correlation between UGT1A1*6, a single nucleotide polymorphism causing a Gly71Arg substitution, and breast cancer susceptibility. Forty-six women diagnosed with breast cancer, 15 patients with gastrointestinal cancer, and 13 healthy women were recruited to this study. The genotype in the polymorphic UGT1A1 locus was determined by DNA sequencing. The frequency of each genotype was compared among the three groups. The frequency of the UGT1A1*6 allele was significantly higher in breast cancer and gastrointestinal cancer patients than that in healthy females (both P < 0.05). No significant associations were observed between the UGT1A1*6 polymorphism and estrogen receptor, progesterone receptor, HER-2 expression status, menstrual status, or metastasis (all P > 0.05). Therefore, the UGT1A1*6 polymorphism was deduced to be a risk factor for breast cancer in women of Han Chinese ethnicity. UGT1A1 may serve as a therapeutic target for the prevention and treatment of breast cancer and other estrogen-related diseases.

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The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis

Cited by 21 publications

References 25 publications

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women

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