The association between the 2D:4D ratio and psychopathic characteristics

Perez, Katherine L; Boisvert, Danielle; Cooke, Eric M.; Connolly, Eric J.; Wells, Jessica; Lewis, Richard H.; Woeckener, Matthias; Armstrong, Todd A.

doi:10.1016/j.heliyon.2022.e12171

Cited by 3 publications

(3 citation statements)

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“…Low 2D:4D ratio, indicating exposure to higher levels of testosterone prenatally, has also been associated with psychopathic characteristics (Blanchard et al, 2016;Perez et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Low 2D:4D ratio, indicating exposure to higher levels of testosterone prenatally, has also been associated with psychopathic characteristics (Blanchard et al, 2016; Perez et al, 2022). Studies investigating digit ratios in children with ADHD and anxiety disorders have yielded similar results, with many, but not all, finding evidence for increased prenatal testosterone relating to increased ADHD traits or symptom severity (Davies, 2014; De Bruin et al, 2006; Lemiere et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…We administered a single dose of testosterone shown to masculinize a female rodent brain (100 µg, s.c.) to male and female C57BL/6J pups on the day of birth, which is during a critical period of sex-specific brain organization (14,15,(47)(48)(49)(50)(51). We tested the mice in the three-chamber social approach assay as juveniles (postnatal day (PN) [28][29][30][31][32] and in contextual fear conditioning as adults (PN 53-64). Fig.…”

Section: Introductionmentioning

confidence: 99%

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Excess neonatal testosterone causes male-specific social and fear memory deficits in wild-type mice

Quiñones-Labernik,

Blocklinger,

Bruce

et al. 2023

Preprint

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Neurodevelopmental disorders (ND) disproportionately affect males compared to females, and Autism Spectrum Disorder (ASD) in particular exhibits a 4:1 male bias. The biological mechanisms of this female protection or male susceptibility have not been identified. There is some evidence to suggest that fetal/neonatal gonadal hormones, which play pivotal roles in many aspects of development, may contribute. Here, we investigate the role of testosterone administration during a critical period of development, and its effects on social approach and fear learning in C57BL/6J wildtype mice. Male, but not female mice treated with testosterone on the day of birth (PN0) exhibited deficits in both social behavior and contextual fear conditioning, whereas mice treated with the same dose of testosterone on postnatal day 18 (PN18) did not display such impairments. Testosterone administration did not induce anxiogenic effects or lead to changes in weight compared to the testosterone-treated group. These impairments are relevant to ND and may help identify novel treatment targets.

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“…Low 2D:4D ratio, indicating exposure to higher levels of testosterone prenatally, has also been associated with psychopathic characteristics (Blanchard et al, 2016;Perez et al, 2022).…”

Section: Introductionmentioning

confidence: 99%