The association between the fibrinogen-to-albumin ratio and coronary artery disease severity in patients with stable coronary artery disease

Abstract

Objective Fibrinogen-to-albumin ratio (FAR) is an inexpensive and easily measurable novel inflammatory index that has been found to be associated with atherosclerosis. In this study, we aimed to investigate the association between the FAR and coronary artery disease (CAD) severity in patients with stable CAD. Methods In total, 356 consecutive patients with CAD were classified into three groups, those with a low Synergy between percutaneous coronary intervention and the Taxus and Cardiac Surgery Study (SYNTAX) score (≤22), those with an intermediate SYNTAX score (23≥ SYNTAX score ≤32) and those with a high SYNTAX score (>32). Results We determined that there were significant differences in the mean age (P < 0.001), male gender (P = 0.008), serum fibrinogen (P = 0.03), low-density lipoprotein cholesterol (P < 0.001) and FAR (P < 0.001) among the SYNTAX score groups. A strong positive correlation was detected between FAR and SYNTAX score (r = 0.899; P < 0.001), and the cutoff level of FAR for high SYNTAX score was 82 (sensitivity of 82%, specificity of 88.3% and an area under the curve of 0.826). Conclusion The novel inflammatory index, FAR, is significantly associated with the severity of CAD in patients with stable CAD.

Relationship Between the Fibrinogen-to-Albumin Ratio and SYNTAX Score in Patients with Non-St-Elevation Myocardial Infarction

“…A small number of studies have investigated the relationship between FAR and SYNTAX score in patients with CAD. 8 and in the stable CAD population by Karahan et al 9 A possible explanation for this observation is that NSTEMI represents a more complicated disease as a result of chronic inflammation. The association between FAR and SYNTAX score can help advance our understanding of the inflammatory process of atherosclerosis.…”

“…A vast number of non-ST-elevation MI (NSTEMI) patients have multivessel disease 7 , and SYNTAX score is crucial in determining the selection of optimal revascularization strategy. A previous study found that the fibrinogen-to-albumin ratio (FAR) was useful in predicting SYNTAX score in patients with stable angina pectoris 8 . Another study has demonstrated that FAR is associated with SYN-TAX score and related to no-reflow after primary percutaneous intervention in ST-elevation MI (STEMI) patients 9 .…”

“…Karahan et al demonstrated that a FAR of >87 was the cutoff point for predicting an intermediate/high SYNTAX score in patients with STEMI, with a sensitivity and specificity of 70%9 . Celebi et al determined that a FAR of >82 was the cutoff point for predicting an intermediate/high SYNTAX score in patients with stable CAD, with a sensitivity of 82% and a specificity of 88.3%8 . However, to our knowledge, the association of FAR with SYNTAX score has not been adequately researched in NSTEMI.…”

Predictive Value of Fibrinogen-to-Albumin Ratio for Post-Contrast Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention

“…FAR has been found to improve the clinical implication in multiple settings, including cardiovascular diseases. For example, FAR has been reported to be significantly correlated with the severity of coronary stenosis in patients with stable angina [ 44 ] and ST-elevation myocardial infarction [ 45 ], and can predict the occurrence of adverse cardiovascular events after PCI [ 14 – 16 ]. Furthermore, FAR is a useful biomarker for predicting the coronary slow-flow and no-reflow phenomenon [ 46 , 47 ].…”

Association between fibrinogen-to-albumin ratio and the presence and severity of coronary artery disease in patients with acute coronary syndrome

“…Several evidence indicate that low albumin level is associated with atherosclerotic cardiovascular diseases and related to the major adverse cardiovascular events (MACE) [ 14 , 15 ]. Recent researches revealed that FAR is efficient in predicting the presence and severity of diseased coronary artery in ST-segment elevation myocardial infarction (STEMI) [ 16 , 17 ]. In this study, we aim to investigate the relation of FAR with the presence and severity of coronary artery disease in patients with ACS undergoing coronary angiography (CAG).…”