The Association Between the Gut Microbiome, Nutritional Habits, Antibiotics, and Gastric Cancer: a Scoping Review

Thrastardottir, Tinna Osk; Copeland, Viana Jacquline; Constantinou, Constantina

doi:10.1007/s13668-021-00391-z

Cited by 8 publications

(9 citation statements)

References 42 publications

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“…A recent scoping review evidenced that a more versatile high-fat diet was associated with a higher rate of intestinal microbial dysbiosis, as well as with increased GC risk, as it led to an overabundance of Lactobacillaceae family reaching the stomach. Conversely, a high intake of fruit, vegetables, dairy products, and seafood presented a protective microbial signature and an inverse correlation with GC [95].…”

Section: Dietary Patternsmentioning

confidence: 94%

Microbiota–Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies

Raoul,

Maccauro,

Cintoni

et al. 2024

IJMS

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Gastric cancer (GC) is one of the most common causes of cancer deaths, and GC treatments represent a large area of research. Although initially regarded as a sterile organ and unsuitable for microbial communities, the discovery of Helicobacter pylori made us realize that some microbes can colonize the stomach. In recent years, growing interest in gastric bacteria has expanded to the gut microbiota and, more recently, to the oral microbiota. Indeed, the oral–gastric–gut microbiota axis may play a crucial role in maintaining homeostasis, while changes in microbiota composition in GC patients can influence clinical outcomes. On the one hand, the microbiota and its metabolites may significantly influence the progression of GC, while anti-GC treatments such as gastrectomy and chemotherapy may significantly impact the oral–gastric–gut microbiota axis of GC patients. In this context, the role of nutritional therapies, including diet, prebiotics, and probiotics, in treating GC should not be underestimated. Wit this review, we aim to highlight the main role of the gastric, oral, and gut microbiota in GC onset and progression, representing potential future biomarkers for early GC detection and a target for efficient nutritional therapies during the course of GC.

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Section: Dietary Patternsmentioning

confidence: 94%

Microbiota–Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies

Raoul,

Maccauro,

Cintoni

et al. 2024

IJMS

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“…In 2018, the Korean Central Cancer Registry reported that the age-adjusted incidence rates of GC for all registrants, males and females were 30.4, 44.3, and 18.3 per 100,000, respectively [ 2 ]. Several etiological factors have been associated with the risk of GC including lifestyle factors, genetics, gut microbiome, and clinical factors [ 3 , 4 ]. Understanding the genetic basis of GC risk reveals insights into the pathogenesis of GC occurrence.…”

Section: Introductionmentioning

confidence: 99%

Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population

Pyun¹,

Gunathilake²,

Lee³

et al. 2024

Cancer Res Treat

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Purpose We aimed to identify the associated single nucleotide polymorphisms (SNPs) with gastric cancer (GC) risk by genome-wide association study (GWAS) and to explore the pathway enrichment of implicated genes and gene-sets with expression patterns.Materials and Methods The study population was comprised of 1,253 GC cases and 4,827 controls from National Cancer Center and an urban community of the Korean Genome Epidemiology Study and their genotyping was performed. SNPs were annotated, and mapped to genes to prioritize by three mapping approaches by functional mapping and annotation (FUMA). The gene-based analysis and gene-set analysis were conducted with full GWAS summary data using MAGMA. Gene-set pathway enrichment test with those prioritized genes were performed.Results In GWAS, rs2303771, a nonsynonymous variant of KLHDC4 gene was top SNP associated significantly with GC (odds ratio, 2.59; p=1.32×10–83). In post-GWAS, 71 genes were prioritized. In gene-based GWAS, seven genes were under significant p < 3.80×10–6 (0.05/13,114); DEFB108B had the lowest p=5.94×10–15, followed by FAM86C1 (p=1.74×10–14), PSCA (p=1.81×10–14), and KLHDC4 (p=5.00×10–10). In gene prioritizing, KLDHC4 was the only gene mapped with all three gene-mapping approaches. In pathway enrichment test with prioritized genes, FOLR2, PSCA, LY6K, LYPD2, and LY6E showed strong enrichment related to cellular component of membrane; a post-translation modification by synthesis of glycosylphosphatidylinositol (GPI)-anchored proteins pathway.Conclusion While 37 SNPs were significantly associated with the risk of GC, genes involved in signaling pathways related to purine metabolism and GPI-anchored protein in cell membrane are pinpointed to be playing important role in GC.

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“…A recent study has shown that gut microbiota is associated with clinical response to anti-programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1 (PD-L1) immunotherapy in gastrointestinal cancers and could consequently be potential predictive biomarkers of response [7]. At the same time, dietary habits and nutritional status may play an important role in affecting GC development and particularly immunotherapy responses through gut microbiota modulation [8]. Thus, during the GC course, the microbiota may be shaped by dietary interventions impacting gut inflammation, the mucosal immune response, and the synthesis or modulation of oncologic molecular processes.…”

Section: Introductionmentioning

confidence: 99%

Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota

Raoul,

De Gaetano,

Sciaraffia

et al. 2024

Pathogens

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Immune checkpoint inhibitors (ICI) have revolutionized the treatment of gastric cancer (GC), which still represents the third leading cause of cancer-related death in Western countries. However, ICI treatment outcomes vary between individuals and need to be optimized. Recent studies have shown that gut microbiota could represent a key influencer of immunotherapy responses. At the same time, the nutritional status and diet of GC patients are also predictive of immunotherapy treatment response and survival outcomes. The objective of this narrative review is to gather recent findings about the complex relationships between the oral, gastric, and gut bacterial communities, dietary factors/nutritional parameters, and immunotherapy responses. Perigastric/gut microbiota compositions/functions and their metabolites could be predictive of response to immunotherapy in GC patients and even overall survival. At the same time, the strong influence of diet on the composition of the microbiota could have consequences on immunotherapy responses through the impact of muscle mass in GC patients during immunotherapy. Future studies are needed to define more precisely the dietary factors, such as adequate daily intake of prebiotics, that could counteract the dysbiosis of the GC microbiota and the impaired nutritional status, improving the clinical outcomes of GC patients during immunotherapy.

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The Association Between the Gut Microbiome, Nutritional Habits, Antibiotics, and Gastric Cancer: a Scoping Review

Cited by 8 publications

References 42 publications

Microbiota–Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies

Microbiota–Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies

Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population

Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota

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