The Association between the Polymorphisms in a Sodium Channel GeneSCN7Aand Essential Hypertension: A Case-Control Study in the Northern Han Chinese

Abstract

SummaryNa x , an α-subunit of the sodium channel encoded by the SCN7A gene, has been deemed to be a sensor of the concentration of sodium in the brain and may be involved in salt intake behavior. We inferred that Na x /SCN7A may participate in the regulation of blood pressure and the pathogenesis of essential hypertension (EH). The present case-control study involving 615 hypertensives and 617 normotensives was performed to investigate the association between SCN7A polymorphisms and EH in the Northern Han Chinese population. The three common single nucleotide polymorphisms (SNPs) (rs3791251, rs6738031, rs7565062) in the exons of SCN7A were genotyped with the TaqMan assay. Significant association between SNP rs7565062 and EH was found under the addictive and dominant genetic models (P = 0.024, OR = 1.283, 95%CI [1.033-1.592]; P = 0.013, OR = 1.203, 95%CI [1.040-1.392]; respectively). The three SNPs were in close pair-wise linkage disequilibrium with each other and the haplotype analyses indicated that haplotype G-A-T was significantly associated with increased risk of EH (P = 0.023, OR = 1.290). In conclusion, our data showed that SNP rs7565062 of SCN7A was significantly associated with EH and the allele T of rs7565062 or the related haplotype G-A-T will be a genetic risk factor for EH in the Northern Han Chinese population.

A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

“…3B) (23). Highly divergent genes in this pathway are mainly involved in ion transport (SCN7A, SLC9A1, ATP1A4, and CACNA2D4), which is important for myocardial function (24). We also found strong signals of adaptation in two major adrenergic receptors (ADRA1A and ADRA2B), as previously reported (7).…”

[Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a

“…Na x is considered to fulfill the criteria of brain [Na + ] sensor because it detects small increases in extracellular [Na + ] (Hiyama et al, 2002(Hiyama et al, , 2013. Of note, a recent epidemiological study suggested that polymorphisms in the SCN7A gene encoding Na x were associated with ''essential hypertension'' (Zhang et al, 2015). Collectively, these findings support our view that information on [Na + ] increases in body fluids sensed by Na x in the OVLT is used for BP control.…”

Molecular determinants of nephron vascular specialization in the kidney

“…3d). The GCs specifically express two of the voltage gated channels, Kcnj5 and Scn7a , which are both linked to hypertension 27,28 (Fig. 3h, i).…”