The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Yu, Ya‐Hui; Sun, Xiaoying; Wang, Xinrui; Xiao, Feng

doi:10.18433/jpps31500

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Third, the between-study heterogeneity was significant even though we had considered different definitions of preeclampsia, different methods of measurement, participants' fasting status, and various conditions for storage. However, it was also reflected in other similar meta-analysis covering the correlation between trace elements or vitamins and preeclampsia (84)(85)(86).…”

Section: Figurementioning

confidence: 82%

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Jin

Zheng

2022

Front. Public Health

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BackgroundPreeclampsia (PE) is a multi-organ syndrome that onsets in the second half of pregnancy. It is the second leading cause of maternal death globally. The homeostasis of zinc (Zn) levels is important for feto-maternal health.ObjectiveWe aimed to collect all studies available to synthesize the evidence regarding the association between maternal Zn levels and the risk of preeclampsia.MethodsA systematic review and meta-analysis was conducted via searching seven electronic databases [PubMed, Web of Science, Embase, African Journals Online (AJOL), ClinicalTrial.gov, and two Chinese databases: Wanfang and Chinese National Knowledge Infrastructure, CNKI]. Studies reporting maternal serum Zn levels in pregnant women with or without preeclampsia were included. Eligible studies were assessed through Newcastle-Ottawa Scale (NOS) and the meta-analysis was performed via RevMan and Stata. The random-effects method (REM) was used for the meta-analysis with 95% confidence interval (CI). The pooled result was assessed using standard mean difference (SMD). The heterogeneity test was carried out using I2 statistics, and the publication bias was evaluated using Begg's and Egger's test. Meta-regression and sensitivity analysis was performed via Stata software.ResultsA total of 51 studies were included in the final analysis. 6,947 participants from 23 countries were involved in our study. All studies went through the quality assessment. The pooled results showed that maternal serum Zn levels were lower in preeclamptic women than in healthy pregnant women (SMD: −1.00, 95% CI: −1.29, −0.70). Sub-group analysis revealed that geographical, economic context, and disease severity may further influence serum Zn levels and preeclampsia.LimitationsThere are significant between-study heterogeneity and publication bias among included studies.ConclusionsA lower level of maternal Zn was associated with increased risks of preeclampsia. The associations were not entirely consistent across countries and regions worldwide.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=337069, Identifier: CRD42022337069

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Section: Figurementioning

confidence: 82%

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Jin

Zheng

2022

Front. Public Health

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“…In a 2021 meta-analysis, 20 studies with 359 041 patients were identified including three RCTs and 17 cohort studies. Pooled estimates showed an RR of 0.83 (95% CI 0.74 to 0.93, p=0.0008) for association between low-dose folic acid and the risk of pre-eclampsia 154. Multivitamins/minerals were not assessed.…”

Section: Resultsmentioning

confidence: 99%

Dietary factors that affect the risk of pre-eclampsia

Perry

Stephanou

Rayman

2022

BMJNPH

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Pre-eclampsia affects 3%–5% of pregnant women worldwide and is associated with a range of adverse maternal and fetal outcomes, including maternal and/or fetal death. It particularly affects those with chronic hypertension, pregestational diabetes mellitus or a family history of pre-eclampsia. Other than early delivery of the fetus, there is no cure for pre-eclampsia. Since diet or dietary supplements may affect the risk, we have carried out an up-to-date, narrative literature review to assess the relationship between nutrition and pre-eclampsia. Several nutrients and dietary factors previously believed to be implicated in the risk of pre-eclampsia have now been shown to have no effect on risk; these include vitamins C and E, magnesium, salt, ω-3 long-chain polyunsaturated fatty acids (fish oils) and zinc. Body mass index is proportionally correlated with pre-eclampsia risk, therefore women should aim for a healthy pre-pregnancy body weight and avoid excessive gestational and interpregnancy weight gain. The association between the risk and progression of the pathophysiology of pre-eclampsia may explain the apparent benefit of dietary modifications resulting from increased consumption of fruits and vegetables (≥400 g/day), plant-based foods and vegetable oils and a limited intake of foods high in fat, sugar and salt. Consuming a high-fibre diet (25–30 g/day) may attenuate dyslipidaemia and reduce blood pressure and inflammation. Other key nutrients that may mitigate the risk include increased calcium intake, a daily multivitamin/mineral supplement and an adequate vitamin D status. For those with a low selenium intake (such as those living in Europe), fish/seafood intake could be increased to improve selenium intake or selenium could be supplemented in the recommended multivitamin/mineral supplement. Milk-based probiotics have also been found to be beneficial in pregnant women at risk. Our recommendations are summarised in a table of guidance for women at particular risk of developing pre-eclampsia.

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“…Se considera que las concentraciones de homocisteína por encima de 10 μM son factores de riesgo para esta condición. Hasta la fecha se han descrito varios mecanismos diferentes por los que la homocisteína induce estrés oxidativo (Yu et al, 2021):…”

Section: Conocidaunclassified

“…Por otra parte, es responsable de la aparición de patologías que son mediadas por una angiopatía o vasculopatía a nivel placentario como son: el aborto espontáneo que puede ser causado por los efectos embriotóxicos directos de la homocisteína. y, desde otra perspectiva, por la lesión vascular en la decidua con alteración en las vellosidades coriales (Yu et al, 2021).…”

Section: Conocidaunclassified

Trastornos hipertensivos durante el embarazo

Paneque¹,

Fernández²,

Quiñones³

et al. 2022

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La obra aborda aspectos importantes como: factores de riesgos, clasificación, algunas condiciones intrínsecas y extrínsecas vinculadas a esta patología, su etiopatogenia y fisiopatología, complicaciones maternas y perinatales; así como sus protocolos de atención, destacándose: el control de la hipertensión arterial, prevención de la convulsión eclámptica, vigilancia biológica y optimización de la extracción; con el propósito de estabilizar a la gestante en espera de la interrupción del embarazo como tratamiento definitivo que será dependiente de la edad gestacional y las condiciones clínicas materno fetales.

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The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 34 publications

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

Dietary factors that affect the risk of pre-eclampsia

Trastornos hipertensivos durante el embarazo

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