The association between the serum concentration of canine prostate specific esterase (CPSE) and the size of the canine prostate

Holst, Bodil Ström; Holmroos, Elin; Friling, L.; Hanås, Sofia; Langborg, Liss-Marie; Franko, Motty; Hansson, Kerstin

doi:10.1016/j.theriogenology.2017.01.032

Cited by 29 publications

(51 citation statements)

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“…The suitability of the blood plasma CPSE concentration as an indicator of BPH was evaluated in a large variety of breeds excluding the Rhodesian Ridgeback breed (Gobello & Corrada, ; Gobello et al, ; Lévy et al, , ; Holst et al, ; Pinheiro et al, ; Alonge et al, ). In our study, the correlations of CPSE with age and prostate gland volume (Table ) may confirm this assessment.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the only use of the peripheral CPSE concentration as indicator of BPH in clinically asymptomatic dogs cannot be recommended in general and especially not in this breed. This may not only be true for the CPSE assay, used in our study, but also for other test systems(Alonge et al, 2018;Holst et al, 2017).…”

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confidence: 92%

“…By means of this, blood serum CPSE concentrations may serve as a valuable indicator for early diagnosis of BPH and for controlling the effect during medical therapy of BPH (Alonge, Melandri, Leoci, Lacalandra, & Aiudi, ; Gobello, Castex, & Corrada, ; Gobello & Corrada, ; Pinheiro et al, ). CPSE concentrations of ≤50 ng/ml (Alonge et al, ), ≤60 ng/ml (Pinheiro et al, ) and ≤90 ng/ml (Holst et al, ) were set as threshold values for dogs with healthy prostate glands using different test systems, especially for identifying BPH in asymptomatic dogs.…”

Section: Introductionmentioning

confidence: 99%

“…CPSE concentrations of ≤50 ng/ml (Alonge et al, 2018), ≤60 ng/ml (Pinheiro et al, 2017) and ≤90 ng/ml (Holst et al, 2017) were set as threshold values for dogs with healthy prostate glands using different test systems, especially for identifying BPH in asymptomatic dogs. Krawiec and Heflin (1992) direct attention to an increased prevalence of prostate diseases in medium-and large-sized dogs, especially in Dobermans and German Shepherds, without special reference to BPH.…”

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confidence: 99%

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Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

Beining

Urhausen

Wolf

et al. 2020

Reprod Domestic Animals

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Benign prostatic hyperplasia (BPH) is an age‐dependent primarily non‐inflammatory enlargement of the accessory gland in the intact dog. The aim of the present study was to control a previously raised suspicion of a breed‐related higher incidence of BPH in dogs of the Rhodesian Ridgeback breed. For this, 18 Labrador Retrievers/LR and 20 Rhodesian Ridgebacks/RR were assigned to the age groups 18–24 months (n = 12), 25–48 months (n = 13) and 49–72 months (n = 13). Prostate gland status was determined by rectal palpation, B‐mode ultrasound, calculation of the prostate gland volume and semen analysis regarding haemospermia and was classified according to blood plasma concentrations of canine prostate‐specific arginine esterase (CPSE) (normal ≤ 60 ng/ml, increased ≥ 61 ng/ml; Pinheiro et al., 2017). Concentrations of testosterone, 5α‐dihydrotestosterone and estradiol were analysed in peripheral blood serum or plasma for detecting breed‐specific conditions regarding the endocrine metabolism. Prostatic volume was significantly larger in RR irrespective of the CPSE status. In RR, BPH occurred more frequently and started at an earlier age compared with the LR. Breed‐related specificities in steroid metabolism in the RR were indicated by correlations of 5α‐dihydrotestosterone and estradiol with age and of testosterone with prostate gland volume. Although the incidence of sonographic signs of BPH and haemospermia did not fit with normal and increased CPSE concentrations, a breed‐specific higher incidence of BPH in the RR breed could be clearly verified.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

Beining

Urhausen

Wolf

et al. 2020

Reprod Domestic Animals

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“…Serum evaluation of CPSE, considered as the most representative marker of prostate secretion activity, may be helpful for diagnosis because it increases in the course of BHP (Holst et al, ; Lévy & Mimouni, ; Lévy, Niżański, Heimendahl, & Mimouni, ; Pinheiro et al, ; Wolf et al, ). The results obtained by Holst et al () revealed that dogs with an increase of prostate volume higher than 2.5 times of normal expected volume showed serum CPSE levels more than 90 ng/ml (Holst et al, ). The serum evaluation of the CPSE seems to be a new frontier in clinical practice such as screening tests for prostate disease prevention or as routine tests for possible follow‐ups (Alonge, Melandro, Leoci, & Audi, ; Lévy, Mimouni, Loukeri, & Claret, ).…”

Section: Benign Prostatic Hyperplasiamentioning

confidence: 99%

Clinical approach to prostatic diseases in the dog

Cunto

Mariani

Guido

et al. 2019

Reprod Domestic Animals

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Contents In small animal practice, prostatic diseases are increasingly encountered. All dogs may experience prostatic disease, but particular care should be addressed to breeding dogs, in which prostatic affection may lead to decrease in semen quality and fertility. The most common prostatic disease is the benign prostatic hyperplasia (BPH) followed by prostatitis, prostatic neoplasia and prostate squamous metaplasia. These diseases do not have pathognomonic symptoms, therefore, making a correct diagnosis may not be easy. An accurate clinical examination and a correct diagnostic protocol are essential in order to begin the most appropriate treatment, and also to do a good prophylaxis where it is possible. BPH therapy is usually recommended when mild‐severe signs are present or if symptoms disturb the patient. New therapeutic approaches, both medical and surgical, allow to maintain fertility in most animals with prostatic disorders. Prostate cancer is relatively infrequent. Elective therapy is the surgical one, but it is considered palliative and can result in important post‐operative complications. The aim of this paper is to lay down the most appropriate diagnostic process describing the aetiologies of prostatic disease, their symptoms, the right investigative tools and therapy.

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Highlights on the Canine Prostatic Specific Esterase (CPSE): A diagnostic and screening tool in veterinary andrology

Melandri

Alonge

2020

Veterinary Medicine & Sci

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In the last years, the need to look for an accurate and precise diagnosis of prostatic diseases in dogs has grown. Among other diagnostic tools, the seric CPSE has been studied and identified as a valid and specific biomarker for prostatic disorders, since it can result significantly more elevated in dogs affected by several prostatic abnormalities, such as benign prostatic hyperplasia, bacterial prostatitis and prostatic carcinoma. Therefore, dosing CPSE in serum represents a new diagnostic and screening tool. Dosing CPSE in everyday clinical practice has three objectives: (a) the diagnosis of benign prostatic hyperplasia; (b) the preventive screening of prostatic disorders in healthy dogs; (c) the medical follow‐up in subjects with prostatic disorders during and after medical therapy. Neither circadian rhythms nor transrectal palpation performed during the andrological examination do affect CPSE. A sexual rest of at least 24 hr before dosing CPSE is recommended as it is affected by ejaculation.

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The association between the serum concentration of canine prostate specific esterase (CPSE) and the size of the canine prostate

Cited by 29 publications

References 29 publications

Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

Clinical approach to prostatic diseases in the dog

Highlights on the Canine Prostatic Specific Esterase (CPSE): A diagnostic and screening tool in veterinary andrology

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