The association between thoracic periaortic fat and major adverse cardiovascular events

Kaya, Zeynettin; Ulucan, Şeref; MehmetKayrak,; Akyürek, Ömer; Katlandur, Hüseyin; Keser, Ahmet; Efe, Duran; Özdil, Hüseyin; Ülgen, Mehmet Sıddık

doi:10.1007/s00508-015-0722-x

Cited by 3 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, increased amount of PCF may directly cause impaired diastolic filling through its mechanical compression to prevent ventricle from elastic expansion, resulting in subsequent atrial enlargement [ 22 ]. On the contrary, it has been shown that TAT volume was associated with aortic dimension and certain vasculopathy [ 12 , 13 ] and major adverse cardiovascular events [ 23 ]. Even though, little is known for the potential remote relationship between TAT and human atrial remodeling.…”

Section: Discussionmentioning

confidence: 99%

The Associations between Various Ectopic Visceral Adiposity and Body Surface Electrocardiographic Alterations: Potential Differences between Local and Remote Systemic Effects

et al. 2016

View full text Add to dashboard Cite

BackgroundThe associations between pericardial adiposity and altered atrial conduction had been demonstrated. However, data comparing differential effects of various body sites visceral adiposity on atrial and ventricular electrocardiographic alterations remains largely unknown.Methods and ResultsWe assessed both peri-cardial fat (PCF) and peri-aortic visceral adiposity (TAT) using dedicated computed tomography (CT) software (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA), with anthropometrics including body mass index (BMI) and biochemical data obtained. We further related PCF and TAT data to standardized 12-leads electrocardiogram (ECG), including P and QRS wave morphologies. Among 3,087 study subjects (mean age, 49.6 years; 28% women), we observed a linear association among greater visceral adiposity burden, leftward deviation of P and QRS axes, longer PR interval and widened QRS duration (all p<0.001). These associations became attenuated after accounting for BMI and baseline clinical co-variates, with greater PCF remained independently associated with prolonged QRS duration (β = 0.91 [95% CI: 0.52, 1.31] per 1-SD increase in PCF, p<0.001). Finally, both PCF and TAT showed incremental value in identifying abnormally high PR interval (>200ms, likelihood-ratio: 33.17 to 41.4 & 39.03 for PCF and TAT) and widened QRS duration (>100ms, likelihood-ratio: 55.67 to 65.4 & 61.94 for PCF and TAT, all X2 p<0.05) when superimposed on age and BMI.ConclusionWe show in our data greater visceral fat burden may have differential associations on several body surface electrocardiographic parameters. Compared to remote adiposity, those surrounding the heart tissue demonstrated greater influences on altered cardiac activation or conduction, indicating a possible local biological effect.

show abstract

Section: Discussionmentioning

confidence: 99%

The Associations between Various Ectopic Visceral Adiposity and Body Surface Electrocardiographic Alterations: Potential Differences between Local and Remote Systemic Effects

et al. 2016

View full text Add to dashboard Cite

show abstract

Carya cathayensis leaf extract attenuates ectopic fat deposition in liver, abdomen and aortic arch in ovariectomized rats fed a high-fat diet

et al. 2021

View full text Add to dashboard Cite

Correlation Between Aortic Adipose Tissue and the Indexed Aortic Diameter According to CT Angiography Findings

Boudagh,

Pouraliakbar,

Maleki

et al. 2024

Int Cardiovasc Res J

View full text Add to dashboard Cite

Background: Aortic aneurysms are dilatations of the aorta that carry a potential risk of rupture. The most common type is the abdominal aortic aneurysm (AAA), while thoracic aortic aneurysms, particularly those in the ascending part, are also significant. Perivascular adipose tissue is an ectopic fat that affects vessels locally by producing bioactive substances. Additionally, central obesity is associated with local aortic diseases. Objectives: The current study aimed to measure periaortic adipose tissue and evaluate its association with the indexed aortic diameter based on multidetector computed tomography (CT) scan findings. Methods: This retrospective and cross-sectional study was conducted in a tertiary center for cardiovascular diseases, continually recruiting 149 patients who had indications for thoracic and abdominal CT angiography. Patients with serious underlying diseases were excluded. The diameters of the aorta and adipose tissue, as well as Body Mass Index, were measured. Data analysis was performed using chi-square, Fisher exact, independent t-test, and Mann–Whitney test with SPSS software, version 16. Comparisons were performed using chi-square or Fisher exact tests for categorical variables, independent t-test for normally distributed data, and Mann–Whitney test for non-normally distributed data. Results: The study population consisted of 149 patients. The prevalence rates of thoracic aortic aneurysm and AAA were 8.7% and 24.8%, respectively. The prevalence of AAA was significantly higher in males (P = 0.025). Patients with AAA and an abdominal aortic diameter exceeding 30 mm were significantly older than the others (P = 0.003). There was a significant correlation between the fat volume around the aorta and the aortic diameter (P < 0.001, r = 0.504). Additionally, significant relationships were found between age and fat volume around both the thoracic and abdominal aorta (P < 0.001 and P < 0.007, r = 0.379 and r = 0.222, respectively), and between body mass index and fat volume around the abdominal aorta (P = 0.044, r = 0.165). Conclusions: The correlation between the volume of periaortic fat tissue and aortic aneurysms was significant in both the thoracic and abdominal aortae. The volume of periaortic fat in AAA was correlated with indexed values, unlike in thoracic aortic aneurysms. In candidates for aortic CT angiography, meticulous measurement of periaortic adipose tissue provides additional valuable data for optimal management.

show abstract

The association between thoracic periaortic fat and major adverse cardiovascular events

Abstract: Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.

Cited by 3 publications

References 31 publications

The Associations between Various Ectopic Visceral Adiposity and Body Surface Electrocardiographic Alterations: Potential Differences between Local and Remote Systemic Effects

The Associations between Various Ectopic Visceral Adiposity and Body Surface Electrocardiographic Alterations: Potential Differences between Local and Remote Systemic Effects

Carya cathayensis leaf extract attenuates ectopic fat deposition in liver, abdomen and aortic arch in ovariectomized rats fed a high-fat diet

Correlation Between Aortic Adipose Tissue and the Indexed Aortic Diameter According to CT Angiography Findings

Contact Info

Product

Resources

About