The Association Between Three Adipocytokines (Adiponectin, Resistin and Visfatin) And Thyroid Status in Patients With Type 2 Diabetes Mellitus and Autoimmune Thyroiditis

Sotak, Štefan; Schroner, Z; Lazúrová, Ivica; Felšöci, Marek; Jochmanová, Ivana; Petrášová, Darina; Bertková, Izabela; Mitníková, M; Novakova, B.; Wagnerova, H; Bobelová, O

doi:10.33549/physiolres.934701

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…This showed that mycosubtilin had the same effect as that of n-butanol site metabolites, suggesting that mycosubtilin could reduce body weight gain in mice by reducing fat accumulation. As a white fat, epididymal fat can not only store energy in the form of TG but can also act as an endocrine organ, secreting a variety of adipocytic factors, such as lipocalin and tumor necrosis factor et al (Sotak et al, 2021). The mice's liver and blood tests revealed that the n-butanol sites and mycosubtilin could significantly reduce the TG and LDL concentration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

Yang,

Zhao,

Yue

et al. 2024

Front. Microbiomes

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Our previous study reported that the metabolite of Bacillus subtilis BS-Z15 n-butanol site could reduce body weight gain in mice, showing anti-obesity effects. This study further demonstrated the effects of purified mycosubtilin on the body weight gain and gut microbiota of Kunming mice. 30 male Kunming white mice were randomly selected into three groups at four weeks of age: Control (group A), gavage-administered with saline daily; n-butanol site treated (group B), gavage-administered with n-butanol site metabolites (90 mg/kg); and mycosubtilin treated (group C), gavage-administered with mycosubtilin (6 mg/kg). Different groups’ gut microbiota compositions were analyzed using high-throughput sequencing technology. The results showed that the effects of mycosubtilin and n-butanol sites were consistent; the treatment groups showed a significant reduction in body weight gain as well as triglyceride and low-density lipoprotein contents as compared to the control group (P <0.05). Moreover, the size and contents of epididymal adipocytes were also significantly reduced (P <0.05), and the gavage administration of mycosubtilin could significantly increase the expression levels of lipolysis gene adipose triglyceride lipase (ATGL) in the mice liver. Mycosubtilin and n-butanol site treatments could significantly alter the composition of the gut microbiota as compared to the physiologic saline treatment. B. subtilis BS-Z15 metabolites may regulate weight gain primarily by mycosubtilin, according to these findings. The mycosubtilin might reduce weight gain in mice by regulating lipid metabolism, thereby reducing fat accumulation and altering the composition of gut microbiota.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

Yang,

Zhao,

Yue

et al. 2024

Front. Microbiomes

View full text Add to dashboard Cite

show abstract

“…This showed that mycosubtilin had the same effect as that of n-butanol site metabolites, suggesting that mycosubtilin could reduce body weight gain in mice by reducing fat accumulation. As a white fat, epididymal fat can not only store energy in the form of TG but can also act as an endocrine organ, secreting a variety of adipocytic factors, such as lipocalin and tumor necrosis factor et al [35]. The mice's liver and blood tests revealed that the n-butanol sites and mycosubtilin could signi cantly reduce the TG and LDL contents.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

Yang

You

et al. 2022

Preprint

View full text Add to dashboard Cite

Our previous study reported that the metabolite of Bacillus subtilis BS-Z15 n-butanol site could reduce body weight gain in mice, showing anti-obesity effects. This study further demonstrated the effects of purified mycosubtilin on the body weight gain and gut microbiota of Kunming mice. 30 male Kunming white mice were randomly selected into three groups at four weeks of age: Control (group A), gavage-administered with saline daily; n-butanol site treated (group B), gavage-administered with n-butanol site metabolites (90 mg/kg); and mycosubtilin treated (group C), gavage-administered with mycosubtilin (6 mg/kg). Different groups' gut microbiota compositions were analyzed using high-throughput sequencing technology. The results showed that the effects of mycosubtilin and n-butanol sites were consistent; the treatment groups showed a significant reduction in body weight gain as well as triglyceride and low-density lipoprotein contents as compared to the control group (P < 0.05). Moreover, the size and contents of epididymal adipocytes were also significantly reduced (P < 0.05), and the gavage administration of mycosubtilin could significantly increase the expression levels of lipolysis gene adipose triglyceride lipase (ATGL) in the mice liver. Mycosubtilin and n-butanol site treatments could significantly alter the composition of the gut microbiota as compared to the physiologic saline treatment. B. subtilis BS-Z15 metabolites may regulate weight gain primarily by mycosubtilin, according to these findings. The mycosubtilin might reduce weight gain in mice by regulating lipid metabolism, thereby reducing fat accumulation and altering the composition of gut microbiota.

show abstract

The Association Between Three Adipocytokines (Adiponectin, Resistin and Visfatin) And Thyroid Status in Patients With Type 2 Diabetes Mellitus and Autoimmune Thyroiditis

Cited by 2 publications

References 43 publications

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

Effect of Bacillus subtilis BS-Z15 metabolite mycosubtilin on body weight gain in mice

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